Advancing global equity in cancer genomics – challenges and opportunities in Sub-Saharan Africa

Munung, Nchangwi Syntia; Ambele, Melvin Anyasi; Moela, Pontsho

doi:10.1016/j.gde.2020.11.006

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…For lung cancer, most notably EGFR, ALK and PD-L1 expression has had a significant impact on management, however, there is very limited data available of molecular profiles of lung cancer patients in SSA. Available data on EGFR expression in African populations is limited to North African populations [ 89 ].…”

Section: Discussionmentioning

confidence: 99%

Advancing oncology drug therapies for sub-Saharan Africa

Sharma

Mayer

et al. 2023

PLOS Glob Public Health

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Cancer incidence is rising across sub-Saharan Africa (SSA), and is often characterized by late-stage presentation, early age of onset and poor survival. While a number of oncology drugs are now improving the length and quality of life for cancer patients in high-income countries, significant disparities in access to a range of oncology therapeutics exist for SSA. A number of challenges to drug access such as drug costs, lack of infrastructure and trained personnel must be urgently addressed to advance oncology therapies for SSA. We present a review of selected oncology drug therapies that are likely to benefit cancer patients with a focus on common malignancies in SSA. We collate available data from seminal clinical trials in high-income countries to highlight the potential for these therapeutics to improve cancer outcomes. In addition, we discuss the need to ensure access to drugs within the WHO Model List of Essential Medicines and highlight therapeutics that require consideration. Available and active oncology clinical trials in the region is tabulated, demonstrating the significant gaps in access to oncology drug trials across much of the region. We issue an urgent call to action to address drug access due to the predicted rise in cancer burden in the region in coming years.

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Section: Discussionmentioning

confidence: 99%

Advancing oncology drug therapies for sub-Saharan Africa

Sharma

Mayer

et al. 2023

PLOS Glob Public Health

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“…Therefore, both the SSA population and Africans in the diaspora will benefit from the inclusion of CGMs due to their shared genomic resemblances and ancestry. Establishing centers of excellence for interdisciplinary cancer genomics in Africa could provide an excellent opportunity for collaboration between biotechnology companies, research institutions, and health systems and manage the cross-border sharing of cancer genomics data, investment, and laws on trade via regional initiatives ( Munung et al, 2021 ).…”

Section: Challenges and Prospects In Pca Genomics Research In Africamentioning

confidence: 99%

Review of prostate cancer genomic studies in Africa

et al. 2022

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Prostate cancer (PCa) is the second most commonly diagnosed in men worldwide and one of the most frequent cancers in men in Africa. The heterogeneity of this cancer fosters the need to identify potential genetic risk factors/biomarkers. Omics variations may significantly contribute to early diagnosis and personalized treatment. However, there are few genomic studies of this disease in African populations. This review sheds light on the status of genomics research on PCa in Africa and outlines the common variants identified thus far. The allele frequencies of the most significant SNPs in Afro-native, Afro-descendants, and European populations were compared. We advocate how these few but promising data will aid in understanding, better diagnosing, and precisely treating this cancer and the need for further collaborative research on the genomics of PCa in the African continent.

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“…Computational tools are then employed to integrate and analyze the data, enabling an understanding of biological processes. The “omics” concept encloses the subfields of genomics [ 3 ], transcriptomics [ 4 ], proteomics [ 5 ], glycoproteomics [ 6 ], glycomics [ 7 ], metabolomics [ 8 ], lipidomics [ 9 ], and several others, providing a comprehensive analysis of the corresponding biomolecules.…”

Section: Introductionmentioning

confidence: 99%

Multi Omics Applications in Biological Systems

Gutierrez Reyes,

Alejo-Jacuinde,

Perez Sanchez

et al. 2024

CIMB

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Traditional methodologies often fall short in addressing the complexity of biological systems. In this regard, system biology omics have brought invaluable tools for conducting comprehensive analysis. Current sequencing capabilities have revolutionized genetics and genomics studies, as well as the characterization of transcriptional profiling and dynamics of several species and sample types. Biological systems experience complex biochemical processes involving thousands of molecules. These processes occur at different levels that can be studied using mass spectrometry-based (MS-based) analysis, enabling high-throughput proteomics, glycoproteomics, glycomics, metabolomics, and lipidomics analysis. Here, we present the most up-to-date techniques utilized in the completion of omics analysis. Additionally, we include some interesting examples of the applicability of multi omics to a variety of biological systems.

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Advancing global equity in cancer genomics – challenges and opportunities in Sub-Saharan Africa

Cited by 6 publications

References 33 publications

Advancing oncology drug therapies for sub-Saharan Africa

Advancing oncology drug therapies for sub-Saharan Africa

Review of prostate cancer genomic studies in Africa

Multi Omics Applications in Biological Systems

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