Advancing fertility preservation in prepubertal mice: Efficacy of ovarian tissue culture and in vitro growth in mature oocyte development
Yuekun Chen,
Yu Wakimoto,
Mizuho Yano
et al.
Abstract:AimThis study aimed to evaluate the ovarian tissue culture and in vitro follicle growth as safer alternatives to cryopreservation for generating in vitro fertilization (IVF)‐ready mature oocytes from prepubertal mice without the risk of cancer cell contamination.MethodsOvaries from prepubertal B6D2F1 mice were cultured in α‐minimum essential medium supplemented with an estrogen receptor antagonist, ICI 182780. Culture duration was investigated to identify the optimal timeframe for follicle growth and oocyte ma… Show more
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