The rapid integration of disruptive digital technologies, including AI, blockchain, and IoT, has significantly transformed global project management, particularly in the realms of planning, execution, and communication. Despite the potential of these innovations to streamline processes and enhance decision-making, there exists a research gap in understanding the challenges these technologies introduce, particularly in cross-cultural communication and interpersonal skills development. This chapter addresses this gap by analyzing case studies across the construction, energy, healthcare, and IT sectors to assess the impact of these technologies. The findings reveal that while disruptive technologies offer substantial opportunities for efficiency and complexity management, they also necessitate new strategies for managing cultural diversity and enhancing team collaboration. The study emphasizes the need for project managers to develop new competencies and organizations to invest in continuous training to leverage disruptive technologies. Policymakers should create regulatory frameworks that support technological adoption while addressing risks like data security. Additionally, the study highlights both the societal benefits of improved efficiency and the ethical concerns, such as job displacement, that must be addressed.