“…Clinicians know, although, that there are many paths to clinical deterioration. For example, the most common forms of deterioration leading to ICU transfer are respiratory instability ( 27 , 30 – 35 ), hemodynamic instability ( 30 , 33 , 34 ), sepsis ( 27 , 36 ), bleeding ( 33 , 36 ), neurologic decompensation ( 36 ), unplanned surgery ( 33 ), and acute renal failure or electrolyte abnormalities ( 36 ). The multiplicity of candidate culprit organ systems suggests that a single model is not likely to catch all the patients who are worsening ( 33 , 34 ).…”