Advancing combination treatment with cilostazol and caffeine for Alzheimer's disease in high fat-high fructose-STZ induced model of amnesia

Gomaa, Adel A.; Farghaly, Hanan S.M.; Ahmed, Abdel Ghaffar M.; El‐Mokhtar, Mohamed A.; Hemida, Fahmy K.

doi:10.1016/j.ejphar.2022.174873

Cited by 5 publications

(3 citation statements)

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“…Ginseng protein is one of the active components of ginseng with anti-AD effects in vivo and in vitro [ 13 , 14 ], and the mechanism of action is associated with the activation of the cyclic adenosine monophosphate/cyclic phosphoadenosine effector element-binding protein (cAMP/CREB) signaling pathway. Brain-derived neurotrophic factor (BDNF) is a CREB downstream effector that binds to tyrosine-protein kinase receptor B (TrkB), causing an increase in TrkB autophosphorylation, which consequently facilitates neuronal growth, survival, and differentiation [ 15 , 16 ] and protects against neuronal damage elicited by β -amyloid (A β ) [ 17 ]. The BDNF/TrkB signaling pathway is closely related to cognitive function, and inactivation of this pathway may lead to abnormal cognitive function [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] The Effective Components, Core Targets, and Key Pathways of Ginseng against Alzheimer’s Disease

Wang

Liu

2023

Evidence-Based Complementary and Alternative Medicine

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Background. Panax ginseng C. A. Mey (ginseng) is a traditional Chinese medicinal herb used for the treatment of nervous system disorders, such as Alzheimer’s disease (AD). However, the pharmacological mechanisms of ginseng involved in AD have not been systematically investigated. Here, a network pharmacology approach was adopted to explore the effective components, core targets, and key pathways of ginseng against AD. Methods. TCMSP database was used to screen the active ingredients of ginseng. Prediction of the targets of ginseng and AD-related genes was performed using online public databases. “Compound-Target,” “Compound-Target-Disease,” “Protein-Protein Interaction (PPI),” “Compound-Target-Pathway,” and “Compound-Target-GO–Pathway” networks were constructed with Cytoscape 3.7.2 software. Gene Ontology (GO) function annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were performed by using the DAVID database. Results. A total of 22 bioactive compounds were identified from ginseng, and 481 targets of ginseng and 763 AD-related targets were obtained from public databases. The PPI network screened out 19 hub genes of ginseng against AD. According to GO function enrichment, ginseng influenced cell proliferation, death, the nitric oxide biosynthetic process, hypoxia response, and synaptic transmission. Neuroactive ligand-receptor interaction, serotonergic synapse, calcium signaling, cAMP signaling, FoxO signaling, Ras signaling, and PI3K-AKT signaling were among the most key regulatory pathways. The compound-target-GO-route network found EGFR, MAPK1, MAPK14, AKT1, CASP3, and PRKACA as key genes, with PI3K-AKT signaling being the most important pathway for ginseng’s anti-AD activity. Conclusion. Ginseng exerts neuroprotective effects in AD patients through multicomponent, multitarget, and multipathway modes, providing novel insight into the pharmacological and experimental research on ginseng against AD.

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Section: Introductionmentioning

confidence: 99%

[Retracted] The Effective Components, Core Targets, and Key Pathways of Ginseng against Alzheimer’s Disease

Wang

Liu

2023

Evidence-Based Complementary and Alternative Medicine

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“…According to our findings, NR2B decreased in the Cf group and NR2A gene expression increased in the SI and SICf groups. Cf (5 mg/kg IP daily for 8 weeks) administration in type II diabetic rats caused a nonsignificant decrease in the NR2B but not NR2A in the hippocampus (Gomaa et al, 2022). In Lin et al's study, NR2A and NR2B were decreased in the hippocampus of neonatal rats due to damage to their synaptic structure and functions (Lin et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Effect of caffeine on hippocampal memory and levels of gene expression in social isolation stress

Musuroglu Keloglan,

Sahin,

Kocahan

et al. 2023

Intl J of Devlp Neuroscience

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BackgroundCaffeine (Cf) antagonizes the adenosine receptors and has neuroprotective properties. The effect of Cf has been seen on stress‐induced deficits of cognitive. In this study, we have investigated the effect of Cf on learning and memory functions induced by social isolation (SI) stress.Materials and methodsIn the present study, 21‐day‐old Wistar albino male rats (n = 28) were divided into four groups: the control (C), the SI, the Cf, and the social isolation + caffeine (SICf). Cf (0.3 g/L) was added to the drinking water of the experimental animals for 4 weeks. The learning and memory functions were assessed using the Morris Water Maze Test (MWMT). Following, was performed histopathological evaluation and determined hippocampal gene expression levels by RT‐qPCR.ResultsAccording to MWMT findings, the time spent in the quadrant where the platform removed was decreased in the SI group compared with the C (p < 0.05). Histological evaluation showed morphological changes in SI by irregular appearance, cellular edema, and dark pycnotic appearance of nuclei in some neurons. However, it was observed that the histological structure of most of the neurons in the SICf group was similar to the C and Cf groups. Hippocampal SNAP25 expression was decreased in the Cf and SICf groups than in the C group (p < 0.05). The GFAP expression was increased in the SICf group than in the C group (p < 0.05). NR2A increased in the SI and SICf groups compared with C and Cf groups (p < 0.05). NR2B expression decreased in the Cf group compared with C and SI groups (p < 0.05).ConclusionsSI impaired spatial memory and causes morphological changes in adolescent rats, but this effect of isolation was not seen in Cf‐treated animals. The effects of SI on NR2A, Cf on NR2B, and SNAP25 are remarkable. Here, we propose that the impaired effect of SI on spatial memory may be mediated by NR2A, but further studies are needed to explain this effect.

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“…Additionally, cilostazol (CSZ) and caffeine normalized the buildup of Amyloid beta (Aβ-42) and phosphorylated tau protein (p-tau) positive cells in the brain of T2D mice. Additionally, some data suggests that CSZ + caffeine will have a more significant impact than either drug alone [32]. Generally, caffeine can improve cognitive function, which is helpful for AD patients, but pregnant women should reduce taking caffeine to prevent the risk of suffering AD.…”

Section: Effects Of Caffeine In Admentioning

confidence: 99%

The Role of A High-Carbohydrates Diet on Alzheimers Disease

Wu,

Zhang,

Zhou

et al. 2023

TNS

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Brain diseases, like majority illnesses, are influenced in some way by nutrition. Alzheimers disease, which is characterized by brain cell deaths and memory loss, is significantly influenced by sugar intake. The frequency, quantity, and type of carbohydrates can influence AD development and outcomes. Whether highly processed or not, carbohydrate-rich foods influence AD. This paper discusses how a high-carbohydrate diet increases the chances of AD development and aggravation. General introduction to carbohydrate diets and the etiology of AD are explained. Subsequently, details on nonmodified and modified AD risk factors are addressed. The present paper moreover examines the imperative relationship between AD and high-carbohydrates diets. Particularly, the paper elucidates how: carbohydrate-rich diets impair cognitive function; how the diet aggravates AD ramifications. Furthermore, the paper evaluates how high-carbohydrates diets: alter AD biomarkers; interact with age to influence AD; and how carbohydrate-rich diets prevent brain cell growth and repair. The report addresses the prevailing therapeutic methods that can be employed to prevent and manage Alzheimers disease. Such interventions include the use of caffeine to significantly less cognitive deterioration in AD patients is addressed. Other interventions addressed regard how ketogenic diets can effectively aid with AD prevention; minimal sugar consumption; and how physical activities can aid AD prevention and management. Besides, AD-derived diseases are also addressed. The paper finds that high-carbohydrate diets should be avoided, and healthier lifestyle practices are integral for AD prevention and management.

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Advancing combination treatment with cilostazol and caffeine for Alzheimer's disease in high fat-high fructose-STZ induced model of amnesia

Cited by 5 publications

References 142 publications

[Retracted] The Effective Components, Core Targets, and Key Pathways of Ginseng against Alzheimer’s Disease

[Retracted] The Effective Components, Core Targets, and Key Pathways of Ginseng against Alzheimer’s Disease

Effect of caffeine on hippocampal memory and levels of gene expression in social isolation stress

The Role of A High-Carbohydrates Diet on Alzheimers Disease

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