Advancing biomedical applications of polyoxometalate-based metal–organic frameworks: from design to therapeutic potential

Abstract

POMOFs (Polyoxometalate-based Metal-Organic Frameworks) are novel materials composed of POMs (Polyoxometalates) and MOFs (Metal-Organic Frameworks), which are widely used in biomedical research. Synthesis strategies for POMOF materials predominantly utilise liquid-phase...

Monolacunary Wells-Dawson Polyoxometalate as a Novel Contrast Agent for Computed Tomography: A Comprehensive Study on In Vivo Toxicity and Biodistribution

“…Accordingly, mono-WD POM merits further in vivo research on imaging efficacy and possible toxicity, which may facilitate the development of inexpensive, safe, and innovative CT contrast agents for clinical application. Finally, future research directions could include the latest potential strategies like deep learning to improve novel contrast agents’ effectiveness and potential innovations in imaging and biomaterial technologies [ 49 , 50 , 51 ].…”

GSH/pH dual-activated POM@MOF for tumor cell-specific synergistic photothermal and chemodynamic therapy

“…Polyoxometalates (POMs) are a class of nanoscale inorganic polymetallic oxygen clusters that have a wide range of applications in catalysis, assembly, and biomedicine. 14–17 Recently, POMs have shown great potential in biomedical research fields due to their high biocompatibility, versatile structures, adjustable compositions, low cost and easy availability. 18,19 Particularly, the reduction of Mo-based POMs to molybdenum blue produces strong absorption in the NIR region, giving Mo-based POMs great potential as PTAs.…”

“…29,30 A variety of POM@MOF materials have been reported in recent years, and the corresponding preparation approaches are well-established. 17,31 POMs residing in the MOF cavity avoid the ineffective encapsulation caused by the surface loading, and maintain a high stability of the POM structure. 32 Notably, MOFs have adjustable inorganic metal centers, which endow them with intrinsic Fenton catalytic activity as a chemodynamic therapy (CDT) agent by tuning the metal center such as Fe and Cu.…”