Advances on the formulation of proteins using nanotechnologies

Santalices, Irene; Gonella, Andrea; Torres, Dolores; Alonso, Marı́a José

doi:10.1016/j.jddst.2017.06.018

Cited by 28 publications

(18 citation statements)

References 278 publications

(427 reference statements)

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“…Lipid-based nanocarriers have been widely described during the last decade as ideal systems for the transport and delivery of active substances that need to be protected from enzymatic and biological degradation [ 47 , 48 , 49 ], and as an option for resolving the common solubility problems that affect lipophilic substances [ 8 , 50 , 51 ]. A mix of solid and liquid lipids is used to formulate nanostructured lipid carriers (NLCs), usually in a ratio of 70:30 [ 49 ].…”

Section: Nanosystems As Components Of Edible Coatingsmentioning

confidence: 99%

Nanosystems in Edible Coatings: A Novel Strategy for Food Preservation

Zambrano-Zaragoza

González-Reza

Mendoza‐Muñoz

et al. 2018

IJMS

213

119

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Currently, nanotechnology represents an important tool and an efficient option for extending the shelf life of foods. Reducing particle size to nanometric scale gives materials distinct and improved properties compared to larger systems. For food applications, this technology allows the incorporation of hydrophilic and lipophilic substances with antimicrobial and antioxidant properties that can be released during storage periods to increase the shelf life of diverse products, including whole and fresh-cut fruits and vegetables, nuts, seeds, and cheese, among others. Edible coatings are usually prepared with natural polymers that are non-toxic, economical, and readily available. Nanosystems, in contrast, may also be prepared with biodegradable synthetic polymers, and liquid and solid lipids at room temperature. In this review, recent developments in the use of such nanosystems as nanoparticles, nanotubes, nanocomposites, and nanoemulsions, are discussed critically. The use of polymers as the support matrix for nanodispersions to form edible coatings for food preservation is also analyzed, but the central purpose of the article is to describe available information on nanosystems and their use in different food substrates to help formulators in their work.

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Section: Nanosystems As Components Of Edible Coatingsmentioning

confidence: 99%

Nanosystems in Edible Coatings: A Novel Strategy for Food Preservation

Zambrano-Zaragoza

González-Reza

Mendoza‐Muñoz

et al. 2018

IJMS

213

119

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“…AMPs have the advantage, over organic small molecule drugs, of producing non-toxic byproducts (Loffet, 2002) and usually exhibit multiple mechanisms making the development of resistance toward them by microbes rare. Even though AMPs are often disadvantaged by their weak ability to traverse the plasma membrane to reach their intended targets, attempts by researchers to develop lipidic and polymeric nanocarriers to deliver peptides (Santalices et al, 2017) make AMPs development promising.…”

Section: Discussion and Future Directionsmentioning

confidence: 99%

Status of Targeting MreB for the Development of Antibiotics

Awuni

2020

Front. Chem.

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Although many prospective antibiotic targets are known, bacterial infections and resistance to antibiotics remain a threat to public health partly because the druggable potentials of most of these targets have yet to be fully tapped for the development of a new generation of therapeutics. The prokaryotic actin homolog MreB is one of the important antibiotic targets that are yet to be significantly exploited. MreB is a bacterial cytoskeleton protein that has been widely studied and is associated with the determination of rod shape as well as important subcellular processes including cell division, chromosome segregation, cell wall morphogenesis, and cell polarity. Notwithstanding that MreB is vital and conserved in most rod-shaped bacteria, no approved antibiotics targeting it are presently available. Here, the status of targeting MreB for the development of antibiotics is concisely summarized. Expressly, the known therapeutic targets and inhibitors of MreB are presented, and the way forward in the search for a new generation of potent inhibitors of MreB briefly discussed.

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“…In this section, only a few examples are given to highlight the potential of different kinds of CDSs for this purpose. Most of the information on this topic comes from pre-clinical studies, but a number of CDSs have been developed that are in various stages of clinical testing or are available commercially, which have been reviewed by other authors [129,130]. For instance, these authors reported that liposomes have been used to encapsulate insulin, anticancer peptides, and virus antigens, but not all of these applications were for oral delivery.…”

Section: Applicationsmentioning

confidence: 99%

Recent Advances in Encapsulation, Protection, and Oral Delivery of Bioactive Proteins and Peptides using Colloidal Systems

Perry

McClements

2020

Molecules

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There are many areas in medicine and industry where it would be advantageous to orally deliver bioactive proteins and peptides (BPPs), including ACE inhibitors, antimicrobials, antioxidants, hormones, enzymes, and vaccines. A major challenge in this area is that many BPPs degrade during storage of the product or during passage through the human gut, thereby losing their activity. Moreover, many BPPs have undesirable taste profiles (such as bitterness or astringency), which makes them unpleasant to consume. These challenges can often be overcome by encapsulating them within colloidal particles that protect them from any adverse conditions in their environment, but then release them at the desired site-of-action, which may be inside the gut or body. This article begins with a discussion of BPP characteristics and the hurdles involved in their delivery. It then highlights the characteristics of colloidal particles that can be manipulated to create effective BPP-delivery systems, including particle composition, size, and interfacial properties. The factors impacting the functional performance of colloidal delivery systems are then highlighted, including their loading capacity, encapsulation efficiency, protective properties, retention/release properties, and stability. Different kinds of colloidal delivery systems suitable for encapsulation of BPPs are then reviewed, such as microemulsions, emulsions, solid lipid particles, liposomes, and microgels. Finally, some examples of the use of colloidal delivery systems for delivery of specific BPPs are given, including hormones, enzymes, vaccines, antimicrobials, and ACE inhibitors. An emphasis is on the development of food-grade colloidal delivery systems, which could be used in functional or medical food applications. The knowledge presented should facilitate the design of more effective vehicles for the oral delivery of bioactive proteins and peptides.

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Advances on the formulation of proteins using nanotechnologies

Cited by 28 publications

References 278 publications

Nanosystems in Edible Coatings: A Novel Strategy for Food Preservation

Nanosystems in Edible Coatings: A Novel Strategy for Food Preservation

Status of Targeting MreB for the Development of Antibiotics

Recent Advances in Encapsulation, Protection, and Oral Delivery of Bioactive Proteins and Peptides using Colloidal Systems

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