Advances on the Antioxidant Activity of a Phytocomplex Product Containing Berry Extracts from Romanian Spontaneous Flora

Moroșan, Elena; Secăreanu, Ana Andreea; Musuc, Adina Magdalena; Mititelu, Magdalena; Ioniță, Ana Corina; Ozon, Emma Adriana; Dărăban, Adriana Maria; Karampelas, Oana

doi:10.3390/pr10040646

Cited by 3 publications

(1 citation statement)

References 71 publications

(78 reference statements)

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“…To prevent the devastating effects of oxidative stress, daily consumption of fruits and vegetables, whole grains, and spices is recommended, and in special situations (activity in the presence of radiation sources, excessively polluted areas, intense physical activity, and intense intellectual activity), it is recommended to supplement the diet with antioxidant supplements [9][10][11][12]. Vegetables and fruits are also important sources of fiber, along with antioxidants, contributing to the alkalization and detoxification of the body [13].…”

Section: Introductionmentioning

confidence: 99%

Pharmacotechnical, Physico-Chemical, and Antioxidant Evaluation of Newly Developed Capsule Formulations

Ozon,

Iuga,

Mititelu

et al. 2023

IJMS

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The excess of free radicals causes numerous imbalances in the body that lead to premature aging, the degradation of internal structures, and the appearance of numerous pathologies responsible for the increased risk of premature death. The present work aims to evaluate the physical, chemical, pharmacotechnical, and antioxidant activity of newly achieved capsule formulations. These two formulations were F1a.i., which contains melatonin:biotin:coenzyme Q10 (weight ratio of 1:2:60), and F2a.i., which contains quercetin:resveratrol:biotin:coenzyme Q10 (weight ratio of 10:10:1:10). The adequate selection of the excipient types and amounts for final capsule formulations (F1c.c., F2c.c.) was based on preformulation studies performed on the powders containing active ingredients. The antioxidant activity assessed using three methods (ABTS, DPPH, and FRAP) compared with acid ascorbic as a positive control demonstrated that the F2c.c. formulation possesses the strongest antioxidant capacity. The results confirmed the suitable formulation and the accurate selection of the types and amounts of active ingredients, as well as the auxiliary excipients used in newly developed capsule formulations as supplements with an excellent antioxidant effect on the human body.

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Section: Introductionmentioning

confidence: 99%

Pharmacotechnical, Physico-Chemical, and Antioxidant Evaluation of Newly Developed Capsule Formulations

Ozon,

Iuga,

Mititelu

et al. 2023

IJMS

Self Cite

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Phytochemicals Present in Ethanol Extract of Avocado Seed and Its Potential Antioxidant Effect

Bastos

Souza

Gomes

et al. 2024

COCAT

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Introduction: Pharmaceutical research currently focuses on methods that allow for more sustainable and natural approaches. In this way, the use of discarded by-products, such as avocado seed, becomes a profitable and sustainable practice. Method: This study evaluated the extraction of phytochemicals from avocado seed (Soxhlet extraction) and compared the antioxidant capacity of avocado seed (DPPH method). The extraction found compounds of different hydrophobicity and a vast amount of compounds that may present the potential for future clinical trials. Result: Avocado extract presented an antioxidant effect (AA%) more effective than Quercetin (3.5%), Ascorbic Acid (2.8%,) and lightly lower than Rutin (-1.9%). Conclusion: Therefore, the avocado seed can be an excellent alternative for research of antioxidants and therapeutic phytochemicals.

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HPLC Analysis of Polyphenolic Compounds in Lysimachia nummularia L. and Comparative Determination of Antioxidant Capacity

et al. 2023

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Lysimachia nummularia L. is a perennial herbaceous plant rich in bioactive compounds, which can be utilized for medicinal purposes. The present work aims to analyze the phenolic compounds from different parts of the Lysimachia nummularia L. plant using the HPLC technique: Lysimachiae radix (the root part), Lysimachiae herba (the aerial part), Lysimachiae flores (flowers). In order to determine the phenolic compounds, extraction from the three categories of vegetable products was performed with ethanol 70% (v/v) using three extraction methods: (i) Soxhlet extraction, (ii) maceration and (iii) ultrasonic-assisted extraction. The content of polyphenols was determined by the Folin–Ciocalteu method, and the antioxidant activity was evaluated by the DPPH, ABTS, FRAP and CUPRAC methods. The antioxidant activity was correlated with the content of phenolic compounds in the analyzed extracts. The following phenolic compounds were separated, identified and quantified: 3-O-methylgallic, gallic, ferulic, caffeic, chlorogenic, p-coumaric acids and trans-resveratrol. According to the experimental data, the highest content of total polyphenols was observed in the hydroethanolic extract from Lysimachiae flores (22.10 ± 1.48 mg gallic acid/g), which also presented remarkable antioxidant activity.

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Advances on the Antioxidant Activity of a Phytocomplex Product Containing Berry Extracts from Romanian Spontaneous Flora

Cited by 3 publications

References 71 publications

Pharmacotechnical, Physico-Chemical, and Antioxidant Evaluation of Newly Developed Capsule Formulations

Pharmacotechnical, Physico-Chemical, and Antioxidant Evaluation of Newly Developed Capsule Formulations

Phytochemicals Present in Ethanol Extract of Avocado Seed and Its Potential Antioxidant Effect

HPLC Analysis of Polyphenolic Compounds in Lysimachia nummularia L. and Comparative Determination of Antioxidant Capacity

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