Advances on Neurogastroenterology and Motility Disorders: Pathophysiology, Diagnostics and Management

Mari, Amir; Savarino, Edoardo

doi:10.3390/jcm11102911

Cited by 3 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 23 , 29 , 51 High-resolution esophageal manometry (HRM) is considered the gold standard modality for the assessment of esophageal motility and the lower esophageal sphincter functions. 52 The practice of HRM systems has permitted a more accurate assessment of esophageal and lower esophageal sphincter functions, with an improved ability to localize the lower esophageal sphincter. Notably, the development of HRM has permitted the creation of the Chicago Classification, currently at its fourth iteration, which is considered as a standardized working algorithm for analyzing and interpreting HRM studies.…”

Section: Introductionmentioning

confidence: 99%

Optimal Assessment, Treatment, and Monitoring of Adults with Eosinophilic Esophagitis: Strategies to Improve Outcomes

Visaggi,

Ghisa,

Vespa

et al. 2024

ITT

Self Cite

View full text Add to dashboard Cite

Eosinophilic esophagitis (EoE) is a chronic type 2 inflammation-mediated disease characterized by an eosinophil-predominant inflammation of the esophagus and symptoms of esophageal dysfunction. Relevant treatment outcomes in the setting of EoE include the improvement of histology, symptoms, and endoscopy findings, quality of life (QoL), and the psychological burden of the disease. Established validated tools for the assessment of EoE include questionnaires on dysphagia and QoL (ie, DSQ, EEsAI, and EoE-IQ). More recently, esophageal symptom-specific anxiety and hypervigilance, assessed using the esophageal hypervigilance and anxiety scale (EHAS), have emerged as contributors to disease burden, confirming the importance of psychological aspects in EoE patients. The EoE endoscopic reference score (EREFS) is the only validated endoscopy score in EoE and can quantify mucosal disease burden. However, esophageal panometry using the functional lumen imaging probe (FLIP) and high-resolution manometry (HRM) have shown potential to optimize the assessment of fibrostenotic features of EoE, providing novel insights into the pathophysiology of symptoms. There is a growing number of licenced and off-label therapeutic options in EoE, with various randomized controlled trials demonstrating the efficacy of proton pump inhibitors, topical steroids, food elimination diets, biological drugs, and esophageal dilatation. However, standardized optimal management strategies of EoE are currently lacking. In this review, we provide an overview of established and novel assessment tools in EoE including patient reported outcomes, FLIP panometry, HRM, endoscopy, and histology outcome measures to improve the outcomes of EoE patients. In addition, we summarize available therapeutic options for EoE based on the most recent evidence.

show abstract

Section: Introductionmentioning

confidence: 99%

Optimal Assessment, Treatment, and Monitoring of Adults with Eosinophilic Esophagitis: Strategies to Improve Outcomes

Visaggi,

Ghisa,

Vespa

et al. 2024

ITT

Self Cite

View full text Add to dashboard Cite

show abstract

“…Many chronic symptoms may originate from functional GI disorders, including those affecting the upper esophageal sphincter (UES), esophageal peristalsis, lower esophageal sphincter (LES), gastric emptying, small intestinal motility and absorptive function, colonic transit, and colonic dysbiosis, as well as disorders related to the anorectal region such as dyssynergia and defects of the anal sphincter [ 2 , 3 ]. Clinically, these disorders may present with a wide range of symptoms including globus sensation, dysphagia, gastroesophageal reflux symptoms, dyspepsia, abdominal pain, bloating, and defecatory disorders such as diarrhea or constipation [ 3 ]. These symptoms contribute to a significant proportion of patients seeking medical care from general physicians and for referrals to specialist gastroenterology clinics.…”

mentioning

confidence: 99%

Diagnostics of Gastrointestinal Motility and Function: Update for Clinicians

Mari

2022

Diagnostics

Self Cite

View full text Add to dashboard Cite

show abstract

Insights into the current state of knowledge, practice, and attitudes of physicians regarding gastrointestinal motility disorders in Egypt

Al Mowafy,

AboKresha,

Elkhadry

et al. 2024

BMC Gastroenterol

View full text Add to dashboard Cite

Background Gastrointestinal (GI) motility disorders are common in clinical settings, but physicians still lack sufficient understanding and effective management of these conditions. Methods This research assessed Egyptian physicians’ knowledge, practices, and attitudes towards GI motility disorders. A cross-sectional survey employing a self-administered questionnaire was carried out among physicians in Egypt. The questionnaire addressed various aspects of physicians’ understanding, practices, and attitudes regarding GI motility disorders. Data analysis was conducted using descriptive statistics and presented as frequencies and percentages. Results A total of 462 physicians took part in the study. Although nearly two-thirds of them knew about GI motility studies, a notable proportion lacked adequate knowledge about GI motility disorders. Notably, 84.2% correctly identified dysphagia as a critical symptom suggestive of an upper GI motility disorder. However, 13.4% incorrectly linked hematemesis with an upper GI motility disorder, and 16.7% expressed uncertainty. In terms of practice, around half of the participants encountered a small number of patients with GI motility disorders (less than 5 per week or even fewer). Only 29.7% felt confident in managing patients with motility disorders. Most participating physicians expressed a willingness to participate in training programs focused on motility disorders. Conclusions This study underscores a knowledge gap among Egyptian physicians concerning GI motility disorders. It suggests the necessity of tailored education and training programs to improve their competency and practice in this domain.

show abstract

Advances on Neurogastroenterology and Motility Disorders: Pathophysiology, Diagnostics and Management

Abstract: Symptoms related to abnormalities in gastrointestinal tract motility and functions are very common in the general population, affecting both pediatrics and adults, from both sexes [1] [...]

Cited by 3 publications

References 23 publications

Optimal Assessment, Treatment, and Monitoring of Adults with Eosinophilic Esophagitis: Strategies to Improve Outcomes

Optimal Assessment, Treatment, and Monitoring of Adults with Eosinophilic Esophagitis: Strategies to Improve Outcomes

Diagnostics of Gastrointestinal Motility and Function: Update for Clinicians

Insights into the current state of knowledge, practice, and attitudes of physicians regarding gastrointestinal motility disorders in Egypt

Contact Info

Product

Resources

About