Advances on Directing-Group Assisted meta-C-H Functionalization Catalyzed by Transition Metal

Abstract

Transition-metal-catalyzed functionalization of unactivated C-H bonds is a highly attractive strategy for the synthesis of organic molecules, however, regioselective control is a central challenge in this field. The directing group assisted C-H functionalizations such as the use of directing templates and transient mediator, secondary interaction have attracted more attentions from researchers. The meta-C-H functionalizatioin assisted by directing groups are summarized in details. The existing problems and limitations of this field are also included. Finally, the development trend of this area is prospected.

Recent Advances in Transition-Metal-Catalyzed C–H Alkylation with Three-Membered Rings

“…The use of diverse directing groups is the most common strategy to control the regioselectivity, reactive speed, and catalytic efficiency in TM-catalyzed C−H bond activation. 20 Nitrogen-containing directing groups (e.g., pyridyl, aminoquinolinyl, imino, and amide), which act as strong σ-donors and/or π-acceptors, have been employed for coordinating a metal and positioning it. 21 For the TM-catalyzed alkylation reactions with strained rings as alkylating reagents, studies have mainly focused on this strategy.…”