Advances of the feasibility study of the European Light Ion Medical Accelerator

Mandrillon, P.; Ostojić, R.; Farley, F. J. M.; Rocher, C.; Susini, A.; Godot, J.C.; Ryckewaert, G.

doi:10.1109/pac.1989.73244

Cited by 5 publications

(5 citation statements)

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“…There are no commercial cyclotron designs for carbon ion therapy available up to now. The company IBA is currently developing a u 400 MeV machine called C-400 (Jongen et al 2010) comparable to what was proposed in the EULIMA project (Mandrillon et al 1987). For 3 He ions, compact and cost-effective cyclotron designs may be feasible due to the relatively low final velocity (relativistic effects that complicate the acceleration in cyclotrons are still moderate at u 260 MeV ) and the less rigid beams would allow lighter magnets in the cyclotron, beam transport lines and gantry with a lower energy consumption.…”

Section: Accelerator Design Aspectsmentioning

confidence: 99%

Physical characterization of ³He ion beams for radiotherapy and comparison with ⁴He

et al. 2021

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There is increasing interest in using helium ions for radiotherapy, complementary to protons and carbon ions. A large number of patients were treated with 4He ions in the US heavy ion therapy project and novel 4He ion treatment programs are under preparation, for instance in Germany and Japan. 3He ions have been proposed as an alternative to 4He ions because the acceleration of 3He is technically less difficult than 4He. In particular, beam contaminations have been pointed out as a potential safety issue for 4He ion beams. This motivated a series of experiments with 3He ion beams at Gesellschaft für Schwerionenforschung (GSI), Darmstadt. Measured 3He Bragg curves and fragmentation data in water are presented in this work. Those experimental data are compared with FLUKA Monte Carlo simulations. The physical characteristics of 3He ion beams are compared to those of 4He, for which a large set of data became available in recent years from the preparation work at the Heidelberger Ionenstrahl-Therapiezentrum (HIT). The dose distributions (spread out Bragg peaks, lateral profiles) that can be achieved with 3He ions are found to be competitive to 4He dose distributions. The effect of beam contaminations on 4He depth dose distribution is also addressed. It is concluded that 3He ions can be a viable alternative to 4He, especially for future compact therapy accelerator designs and upgrades of existing ion therapy facilities.

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Section: Accelerator Design Aspectsmentioning

confidence: 99%

Physical characterization of ³He ion beams for radiotherapy and comparison with ⁴He

et al. 2021

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“…In addition, the radiobiological properties of carbon ions were compared to heavier ions. Finally, socioeconomic studies on possible patient recruitments in the different countries were performed to demonstrate the necessity of a few therapy units all over Europe [22] .…”

Section: The Transition Phase 1980–1997mentioning

confidence: 99%

The history of ion beam therapy in Germany

Jäkel

Kraft

Karger

2022

Zeitschrift für Medizinische Physik

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“…Synchrotrons are instead flexible machines, energy can be rapidly changed, different ion species can be accelerated, and they are a well-established technology. For these reasons, the EULIMA feasibility study recommended using synchrotrons for heavyion therapy [60], and indeed all European ion beam centers are currently using synchrotrons. IBA, the leading company in cyclotrons for proton therapy, is still working on the idea of the superconducting cyclotron for carbon ions (C400) [61], in collaboration with GANIL at Caen (France), but the project is still ongoing.…”

Section: Eulimamentioning

confidence: 99%

Radioactive Beams in Particle Therapy: Past, Present, and Future

Durante

Parodi

2020

Front. Phys.

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Heavy ion therapy can deliver high doses with high precision. However, image guidance is needed to reduce range uncertainty. Radioactive ions are potentially ideal projectiles for radiotherapy because their decay can be used to visualize the beam. Positron-emitting ions that can be visualized with PET imaging were already studied for therapy application during the pilot therapy project at the Lawrence Berkeley Laboratory, and later within the EULIMA EU project, the GSI therapy trial in Germany, MEDICIS at CERN, and at HIMAC in Japan. The results show that radioactive ion beams provide a large improvement in image quality and signal-to-noise ratio compared to stable ions. The main hindrance toward a clinical use of radioactive ions is their challenging production and the low intensities of the beams. New research projects are ongoing in Europe and Japan to assess the advantages of radioactive ion beams for therapy, to develop new detectors, and to build sources of radioactive ions for medical synchrotrons.

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Advances of the feasibility study of the European Light Ion Medical Accelerator

Cited by 5 publications

References 1 publication

Physical characterization of ³He ion beams for radiotherapy and comparison with ⁴He

Physical characterization of ³He ion beams for radiotherapy and comparison with ⁴He

The history of ion beam therapy in Germany

Radioactive Beams in Particle Therapy: Past, Present, and Future

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Advances of the feasibility study of the European Light Ion Medical Accelerator

Cited by 5 publications

References 1 publication

Physical characterization of 3He ion beams for radiotherapy and comparison with 4He

Physical characterization of 3He ion beams for radiotherapy and comparison with 4He

The history of ion beam therapy in Germany

Radioactive Beams in Particle Therapy: Past, Present, and Future

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Product

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Physical characterization of ³He ion beams for radiotherapy and comparison with ⁴He

Physical characterization of ³He ion beams for radiotherapy and comparison with ⁴He