Advances of SIRT4 in cancer metabolism and therapy
Xiaohan Yue,
Yulu Shi,
Qing Luo
Abstract:The Sirtuins family consists of SIRT1‐SIRT7, which belong to class III of the histone deacetylases, a family of highly conserved NAD (nicotinamide adenine dinucleotide)‐dependent enzymes expressed in the nucleus, cytoplasm, and mitochondria. In addition to having ADP‐ribosyltransferase, NAD+‐dependent deacetylase, lipoamide, and long‐chain deacetylase activities, it can also regulate the function of substrate proteins through ADP‐ribosylation, diacylation, and long‐chain deacylation. These enzyme activities al… Show more
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