Advances of Nanoparticles for Leukemia Treatment

Abstract

Leukemia is a liquid tumor caused by a hematopoietic stem cell malignant clone, which seriously affects the normal function of the hematopoietic system. Conventional drugs have poor therapeutic effects due to their poor specificity and stability. With the development of nanotechnology, nonviral nanoparticles bring hope for the efficient treatment of leukemia. Nanoparticles are easily modified. They can be designed to target lesion sites and control drug release. Thereby, nanoparticles can improve the effects of drugs and reduce side effects. This review mainly focuses on and summarizes the current research progress of nanoparticles to deliver different leukemia therapeutic drugs, as to demonstrate the potential of nanoparticles in leukemia treatment.

Nanotechnology-based diagnostics and therapeutics in acute lymphoblastic leukemia: a systematic review of preclinical studies

“…108 All in all, it was necessary to develop a proper animal model capable of more closely simulating leukemia and presenting a more thorough evaluation system. 4,116…”

“…6 As a result, finding and developing smart delivery methods that efficiently preserve and distribute therapeutic medications, improve targeting capabilities, and accomplish controlled release are critical to healing leukemia. 2–4,17–19…”

“…Several issues are to be addressed, including side effects, controlled release, targeted therapy, and the possibility of combinatorial therapy. 2–4,10,31…”

Advanced nanoparticles that can target therapy and reverse drug resistance may be the dawn of leukemia treatment: A bibliometrics study

“…Professor Zhao’s team constructs a novel amino acid nanomedicine for the treatment of T-cell acute lymphoblastic leukemia by combining leukemia cell targeting and immune surveillance stimulation ( Li et al, 2022 ). Nanoparticles can not only treat leukemia by transporting small molecular drugs, antibody drugs, and genes but also carry out photodynamic therapy for leukemia through photosensitizers ( Shen et al, 2020 ). Because the physiological structure of a tumor is different from that of normal tissue, nanoparticles can be passively targeted to the tumor by the Enhanced Permeability and Retention Effect (EPR).…”

Superoxide Dismutase and Vitamin E Levels in Serum as Indicators in Patients with Acute and Chronic Leukemia

“…Leukemia is further divided into two categories depending on cell type: lymphoid and myeloid leukemia. Acute lymphoid leukemia (ALL), acute myeloid leukemia (AML), chronic lymphoid leukemia (CLL), and chronic myeloid leukemia (CML) are the four forms of leukemia [5]. Antioxidants are substances that prevent oxidative damage by interacting with free radicals [6].…”