Advances of Ionic Liquids in Analytical Chemistry

Trujillo−Rodríguez, María J.; He, Nan; Varona, Marcelino; Emaus, Miranda N.; Souza, Israel Donizéti de; Anderson, Jared L.

doi:10.1021/acs.analchem.8b04710

Cited by 195 publications

(104 citation statements)

References 241 publications

(460 reference statements)

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“…Several IL‐ and PIL‐based sorbent coatings have been specifically designed for SPME using the fiber‐type configuration [7,10]. In one study, four different PIL‐based sorbent coatings were employed in a totally automated SPME approach [43].…”

Section: Ionic Liquids and Derivatives In High‐throughput Solid Phasementioning

confidence: 99%

“…ILs and PILs have also been employed in in‐tube SPME mode [7,10]. In particular, a relatively large number of these applications performed the extraction/elution procedure online using a switchable six‐port injection valve directly connected to the analytical detection technique [35–40], as summarized in Table 1 [35–41].…”

Section: Ionic Liquids and Derivatives In High‐throughput Solid Phasementioning

confidence: 99%

“…Ionic liquids (ILs) are a group of non‐molecular solvents with melting points below 100 °C and completely composed by ions, in general, organic cations containing heteroatoms and either inorganic or organic anions [7,8]. ILs are characterized by a low or negligible vapor pressure at room temperature, high thermal stability and conductivity, and variable and modulable viscosity and water solubility depending on the cation/anion combinations within the IL structure [7,8]. These physicochemical properties make ILs outstanding solvents for a wide variety of (bio)analytical applications [9].…”

Section: Introductionmentioning

confidence: 99%

“…ILs and PILs have been widely used as extraction and/or auxiliary solvents/sorbents in several microscale extraction approaches [7,10,14], whereas the use of MILs in LPME has attracted a great deal of attention more recently [7,12]. Despite the high number of studies, most applications reported in the IL‐field use offline or batchwise protocols that require a large number of steps and the intensive intervention of the analyst, which might have a detrimental effect on the method's intermediate precision.…”

Section: Introductionmentioning

confidence: 99%

“…The specific goals pursued with all the above approaches include (i) additional miniaturization of the microscale extraction protocols, (ii) additional minimization of the sample and solvent requirements, (iii) reduction of the analysis time, (iv) online hyphenation of the IL‐microextraction protocol with the subsequent selected analytical technique, and (v) additional minimization of the analyst intervention. However, it is important to note that the implementation of FI and microfluidics in IL‐based microextraction methods might be challenging due to some IL characteristics, e.g., high viscosity or tendency to stick to glass and plastic tubing [7,23]. To this end, research in this area should focus on designing IL materials more compatible with automatic methods.…”

Section: Introductionmentioning

confidence: 99%

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High‐throughput microscale extraction using ionic liquids and derivatives: A review

Trujillo−Rodríguez

Pino

Miró

2020

J of Separation Science

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Ionic liquids and derivatives-mainly polymeric ionic liquids and magnetic ionic liquids-have been extensively used in microscale extraction over the past few years. Current trends in analytical sample preparation gear toward linking microextraction approaches with high-throughput sample processing to comply with green analytical chemistry requirements. A variety of high sample throughput strategies that are coupled to both ionic-liquid-based solid-phase microextraction and ionic liquid-based liquid-phase microextraction are herein reported. The review is focused on microscale extraction methods that use (i) custom-made and dedicated extraction devices, (ii) parallel extraction, (iii) magnetic-based separation, and (iv) miniaturized systems employing semi-automatic or fully automatic flow injection methods, related micro/millifluidic devices, and robotic equipment. K E Y W O R D S automation, ionic liquids, magnetic ionic liquids, polymeric ionic liquids, sample preparation Article Related Abbreviations: γ-MAPS, 3-(trimethoxysilyl) propylmethacrylate; μ-SPE, micro-solid phase extraction; [(AC 3 )MIM + ], 1-aminopropyl-3-methylimidazolium; [(VIM) 2 C 10 2+ ], 1,12-di(vinylimidazolium)decane; [(VIM) 2 C 6

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Section: Ionic Liquids and Derivatives In High‐throughput Solid Phasementioning

confidence: 99%

Section: Ionic Liquids and Derivatives In High‐throughput Solid Phasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

High‐throughput microscale extraction using ionic liquids and derivatives: A review

Trujillo−Rodríguez

Pino

Miró

2020

J of Separation Science

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Derivatization procedures and their analytical performances for HPLC determination in bioanalysis

David

Moldoveanu

Galaon

2020

Biomedical Chromatography

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Derivatization, or chemical structure modification, is often used in bioanalysis performed by liquid chromatography technique in order to enhance detectability or to improve the chromatographic performance for the target analytes. The derivatization process is discussed according to the analytical procedure used to achieve the reaction between the reagent and the target compounds (containing hydroxyl, thiol, amino, carbonyl and carboxyl as the main functional groups involved in derivatization). Important procedures for derivatization used in bioanalysis are in situ or based on extraction processes (liquid-liquid, solid-phase and related techniques) applied to the biomatrix. In the review, chiral, isotope-labeling, hydrophobicity-tailored and post-column derivatizations are also included, based on representative publications in the literature during the last two decades. Examples of derivatization reagents and brief reaction conditions are included, together with some bioanalytical applications and performances (chromatographic conditions, detection limit, stability and sample biomatrix).

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Recent advances and trends in miniaturized sample preparation techniques

Burato

Medina

Toffoli

et al. 2019

J of Separation Science

152

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Advances in the area of sample preparation are significant and have been growing significantly in recent years. This initial step of the analysis is essential and must be carried out properly, consisting of a complicated procedure with multiple stages. Consequently, it corresponds to a potential source of errors and will determine, at the end of the process, either a satisfactory result or a fail. One of the advances in this field includes the miniaturization of extraction techniques based on the conventional sample preparation procedures such as liquid‐liquid extraction and solid‐phase extraction. These modern techniques have gained prominence in the face of traditional methods since they minimize the consumption of organic solvents and the sample volume. As another feature, it is possible to reuse the sorbents, and its coupling to chromatographic systems might be automated. The review will emphasize the main techniques based on liquid‐phase microextraction, as well as those based upon the use of sorbents. The first group includes currently popular techniques such as single drop microextraction, hollow fiber liquid‐phase microextraction, and dispersive liquid‐liquid microextraction. In the second group, solid‐phase microextraction techniques such as in‐tube solid‐phase microextraction, stir bar sorptive extraction, dispersive solid‐phase extraction, dispersive micro solid‐phase microextraction, and microextraction by packed sorbent are highlighted. These approaches, in common, aim the determination of analytes at low concentrations in complex matrices. This article describes some characteristics, recent advances, and trends on miniaturized sample preparation techniques, as well as their current applications in food, environmental, and bioanalysis fields.

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Advances of Ionic Liquids in Analytical Chemistry

Cited by 195 publications

References 241 publications

High‐throughput microscale extraction using ionic liquids and derivatives: A review

High‐throughput microscale extraction using ionic liquids and derivatives: A review

Derivatization procedures and their analytical performances for HPLC determination in bioanalysis

Recent advances and trends in miniaturized sample preparation techniques

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