Advances of functional nanomaterials for cancer immunotherapeutic applications

Hao, Yuhao; Zhou, Xingyu; Li, Rui; Song, Zechenxi; Min, Yuanzeng

doi:10.1002/wnan.1574

Cited by 10 publications

(6 citation statements)

References 161 publications

(188 reference statements)

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“…Previous studies have found that cationic dendrimers, such as PAMAM dendrimers, allow for the complexation of biologically active agents, such as nucleic acids, peptides, and proteins through electrostatic interactions, thereby protecting the materials from immature enzymatic degradation and increasing their transfection efficiency. (Hao et al, 2020; Lalani & Misra, 2011; Salameh et al, 2020; Setaro et al, 2015; Zeng et al, 2016) This feature was exploited in an early study by Daftarian et al (2011), who conjugated PAMAM dendrimers and universal peptides to selectively deliver DNA to antigen‐presenting cells and increase the efficacy of DNA vaccines. Although the group's vaccine design was promising and resulted in the generation of high‐affinity memory cytotoxic T lymphocytes with a robust humoral response, their system was not fully optimized and resulted in tumor regression with a 50% mortality rate.…”

Section: Dendrimer‐based Cancer Immunotherapymentioning

confidence: 99%

Dendrimers for cancer immunotherapy: Avidity‐based drug delivery vehicles for effective anti‐tumor immune response

Rawding

Wang

et al. 2021

WIREs Nanomed Nanobiotechnol

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Cancer immunotherapy, or the utilization of a patient's own immune system to treat cancer, has shifted the paradigm of cancer treatment. Despite meaningful responses being observed in multiple studies, currently available immunotherapy platforms have only proven effective to a small subset of patients. To address this, nanoparticles have been utilized as a novel carrier for immunotherapeutic drugs, achieving robust anti‐tumor effects with increased adaptive and durable responses. Specifically, dendrimer nanoparticles have attracted a great deal of scientific interest due to their versatility in various therapeutic applications, resulting from their unique physicochemical properties and chemically well‐defined architecture. This review offers a comprehensive overview of dendrimer‐based immunotherapy technologies, including their formulations, biological functionalities, and therapeutic applications. Common formulations include: (1) modulators of cytokine secretion of immune cells (adjuvants); (2) facilitators of the recognition of tumorous antigens (vaccines); (3) stimulators of immune effectors to selectively attack cells expressing specific antigens (antibodies); and (4) inhibitors of immune‐suppressive responses (immune checkpoint inhibitors). On‐going works and prospects of dendrimer‐based immunotherapies are also discussed. Overall, this review provides a critical overview on rapidly growing dendrimer‐based immunotherapy technologies and serves as a guideline for researchers and clinicians who are interested in this field. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Section: Dendrimer‐based Cancer Immunotherapymentioning

confidence: 99%

Dendrimers for cancer immunotherapy: Avidity‐based drug delivery vehicles for effective anti‐tumor immune response

Rawding

Wang

et al. 2021

WIREs Nanomed Nanobiotechnol

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“…Inorganic nanoparticles can be prepared via the chemical co-precipitation, microemulsion, and pyrolysis methods (Islam et al, 2012). Inorganic nanoparticles are widely used in drug delivery and tumor therapy due to their unique physical and chemical properties, ease of surface modification, and good biocompatibility (Hao et al, 2020). The primary inorganic nanoparticles used in the context of HPV-related diseases are copper oxide, silica, gold, and zinc oxide (Bayda et al, 2018).…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Nanotechnology in cervical cancer immunotherapy: Therapeutic vaccines and adoptive cell therapy

et al. 2022

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Immunotherapy is an emerging method for the treatment of cervical cancer and is more effective than surgery and radiotherapy, especially for recurrent cervical cancer. However, immunotherapy is limited by adverse effects in clinical practice. In recent years, nanotechnology has been widely used for tumor diagnosis, drug delivery, and targeted therapy. In the setting of cervical cancer, nanotechnology can be used to actively or passively target immunotherapeutic agents to tumor sites, thereby enhancing local drug delivery, reducing drug adverse effects, achieving immunomodulation, improving the tumor immune microenvironment, and optimizing treatment efficacy. In this review, we highlight the current status of therapeutic vaccines and adoptive cell therapy in cervical cancer immunotherapy, as well as the application of lipid carriers, polymeric nanoparticles, inorganic nanoparticles, and exosomes in this context.

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“…High-resolution imaging by multifunctional nanoprobes can also elucidate the mechanisms of immunotherapy 53 , 54 via real-time monitoring of immune cells in the TME and the biodistribution of immunomodulatory drugs at the target site 21 , 32 . Rinat et al 55 labeled melanoma-specific T-cell receptor (TCR)-expressing T cells with Au nanoparticles (AuNNPs) for CT image-guided therapy.…”

Section: Image-guided Immunotherapymentioning

confidence: 99%

“…Nevertheless, multifunctional nanoprobes can obviate the above shortcomings 19 , 20 given their excellent biocompatibility, easy surface modification, and ability to deliver drugs to the target site and protect them against endogenous enzymes 21 . Studies show that nanoprobe-assisted radiotherapy, chemotherapy, photothermal therapy (PTT) and photodynamic therapy (PDT) can stimulate the immune system by inducing immunogenic cell death (ICD) 22 , 23 .…”

Section: Introductionmentioning

confidence: 99%

Tumor immunotherapy and multi-mode therapies mediated by medical imaging of nanoprobes

Yang¹,

Guan²,

Zhang³

2021

Theranostics

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Immunotherapy is an effective tumor treatment strategy that has several advantages over conventional methods such as surgery, radiotherapy and chemotherapy. Studies show that multifunctional nanoprobes can achieve multi-mode image-guided multiple tumor treatment modes. The tumor cells killed by chemotherapies or phototherapies release antigens that trigger an immune response and augment the effects of tumor immunotherapy. Thus, combining immunotherapy and multifunctional nanoprobes can achieve early cancer diagnosis and treatment. In this review, we have summarized the current research on the applications of multifunctional nanoprobes in image-guided immunotherapy. In addition, image-guided synergistic chemotherapy/photothermal therapy/photodynamic therapy and immunotherapy have also been discussed. Furthermore, the application potential and clinical prospects of multifunctional nanoprobes in combination with immunotherapy have been assessed.

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Advances of functional nanomaterials for cancer immunotherapeutic applications

Cited by 10 publications

References 161 publications

Dendrimers for cancer immunotherapy: Avidity‐based drug delivery vehicles for effective anti‐tumor immune response

Dendrimers for cancer immunotherapy: Avidity‐based drug delivery vehicles for effective anti‐tumor immune response

Nanotechnology in cervical cancer immunotherapy: Therapeutic vaccines and adoptive cell therapy

Tumor immunotherapy and multi-mode therapies mediated by medical imaging of nanoprobes

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