Advances in Understanding the Acyl-CoA-Binding Protein in Plants, Mammals, Yeast, and Filamentous Fungi

Qiu, Shangkun; Zeng, Bin

doi:10.3390/jof6010034

Cited by 11 publications

(10 citation statements)

References 68 publications

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“…4C). Lipid droplets were reported to cluster at the meiotic nuclei during meiosis II [32]. Intriguingly, the clustering/fusion of lipid droplets in the presence of nutrient‐rich medium depended on Acb1 (Fig.…”

Section: Discussionmentioning

confidence: 98%

The acyl‐CoA‐binding protein Acb1 regulates mitochondria, lipid droplets, and cell proliferation

Liu

Zheng

et al. 2022

FEBS Letters

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Mitochondria are involved in many cellular activities, including energy metabolism and biosynthesis of nucleotides, fatty acids and amino acids. Mitochondrial morphology is a key factor in dictating mitochondrial functions. Here, we report that the acyl-CoA-binding protein (ACBP) Acb1 in the fission yeast Schizosaccharomyces pombe is required for the maintenance of tubular mitochondrial morphology and proper mitochondrial respiration. The absence of Acb1 causes severe mitochondrial fragmentation in a dynaminrelated protein Dnm1-dependent manner and impairs mitochondrial respiration. Moreover, Acb1 regulates the remodelling of lipid droplets in nutrientrich conditions. Importantly, Acb1 promotes cell survival when cells are cultured in nutrient-rich medium. Hence, our findings establish roles of ACBP in regulating mitochondria, lipid droplets and cell viability.

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Section: Discussionmentioning

confidence: 98%

The acyl‐CoA‐binding protein Acb1 regulates mitochondria, lipid droplets, and cell proliferation

Liu

Zheng

et al. 2022

FEBS Letters

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“…Internalized non-esterified fatty acids also can bind to cytoplasmic Fatty Acid Binding Proteins (FABPs), a large family of soluble, predominantly cytoplasmic proteins distinct from FABPpm ( Glatz and Luiken, 2018 ; McKillop et al., 2019 ). In addition, Acyl-CoA Binding Protein (ACBP) is a cytoplasmic protein that can bind fatty acyl-CoAs and traffic them to intracellular destinations such as ER, Golgi, and mitochondria ( Knudsen et al., 2000 ; Hansen et al., 2008 ; Qiu and Zeng, 2020 ). Finally, Sterol Carrier Protein 2 (SCP-2), which is localized to both the cytoplasm and in peroxisomes ( Keller et al., 1989 ; Gallegos et al., 2001 ), also can bind to a variety of lipids including fatty acids ( Scallen et al., 1985 ; Stolowich et al., 2002 ).…”

Section: Fatty Acid Uptake In Different Organismsmentioning

confidence: 99%

Fatty acid uptake in Trypanosoma brucei: Host resources and possible mechanisms

Poudyal

Paul

2022

Front. Cell. Infect. Microbiol.

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Trypanosoma brucei spp. causes African Sleeping Sickness in humans and nagana, a wasting disease, in cattle. As T. brucei goes through its life cycle in its mammalian and insect vector hosts, it is exposed to distinct environments that differ in their nutrient resources. One such nutrient resource is fatty acids, which T. brucei uses to build complex lipids or as a potential carbon source for oxidative metabolism. Of note, fatty acids are the membrane anchoring moiety of the glycosylphosphatidylinositol (GPI)-anchors of the major surface proteins, Variant Surface Glycoprotein (VSG) and the Procyclins, which are implicated in parasite survival in the host. While T. brucei can synthesize fatty acids de novo, it also readily acquires fatty acids from its surroundings. The relative contribution of parasite-derived vs. host-derived fatty acids to T. brucei growth and survival is not known, nor have the molecular mechanisms of fatty acid uptake been defined. To facilitate experimental inquiry into these important aspects of T. brucei biology, we addressed two questions in this review: (1) What is known about the availability of fatty acids in different host tissues where T. brucei can live? (2) What is known about the molecular mechanisms mediating fatty acid uptake in T. brucei? Finally, based on existing biochemical and genomic data, we suggest a model for T. brucei fatty acid uptake that proposes two major routes of fatty acid uptake: diffusion across membranes followed by intracellular trapping, and endocytosis of host lipoproteins.

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“…The term metabolome represents the total number of metabolites within an organism, and these are the final products of cellular processes. The A. flavus metabolome is of substantial interest since A. flavus is capable of producing the potent carcinogenic and toxic metabolites [ 55 , 56 ]. Apart from aflatoxins and their precursors, A. flavus produces other secondary metabolites, some of which may be toxic (e.g., cyclopiazonic acid, aflatrem, etc.)…”

Section: Metabolomics Analysismentioning

confidence: 99%

Updates on the Functions and Molecular Mechanisms of the Genes Involved in Aspergillus flavus Development and Biosynthesis of Aflatoxins

Tumukunde

Xie

Wang

2021

JoF

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Aspergillus flavus (A. flavus) is a ubiquitous and opportunistic fungal pathogen that causes invasive and non-invasive aspergillosis in humans and animals. This fungus is also capable of infecting a large number of agriculture crops (e.g., peanuts, maze, cotton seeds, rice, etc.), causing economic losses and posing serious food-safety concerns when these crops are contaminated with aflatoxins, the most potent naturally occurring carcinogens. In particular, A. flavus and aflatoxins are intensely studied, and they continue to receive considerable attention due to their detrimental effects on humans, animals, and crops. Although several studies have been published focusing on the biosynthesis of the aforementioned secondary metabolites, some of the molecular mechanisms (e.g., posttranslational modifications, transcription factors, transcriptome, proteomics, metabolomics and transcriptome, etc.) involved in the fungal development and aflatoxin biosynthesis in A. flavus are still not fully understood. In this study, a review of the recently published studies on the function of the genes and the molecular mechanisms involved in development of A. flavus and the production of its secondary metabolites is presented. It is hoped that the information provided in this review will help readers to develop effective strategies to reduce A. flavus infection and aflatoxin production.

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Advances in Understanding the Acyl-CoA-Binding Protein in Plants, Mammals, Yeast, and Filamentous Fungi

Cited by 11 publications

References 68 publications

The acyl‐CoA‐binding protein Acb1 regulates mitochondria, lipid droplets, and cell proliferation

The acyl‐CoA‐binding protein Acb1 regulates mitochondria, lipid droplets, and cell proliferation

Fatty acid uptake in Trypanosoma brucei: Host resources and possible mechanisms

Updates on the Functions and Molecular Mechanisms of the Genes Involved in Aspergillus flavus Development and Biosynthesis of Aflatoxins

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