“…Currently used hypolipidemic drugs administered to regulate LMD are suboptimal as they may cause liver or kidney damage, adverse gastrointestinal reactions, and organismic and other side effects of drug resistance ( Elagina et al, 2020 ). As natural cholesterol-lowering active food ingredients are urgently needed, functional compounds isolated from natural foods are increasingly acknowledged to alleviate LMD ( Li et al, 2019 ; Yang et al, 2020 ; Zhang et al, 2022 ).…”