2008
DOI: 10.1016/j.vetimm.2008.01.008
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Advances in understanding molecular determinants in FeLV pathology

Abstract: Feline leukemia virus (FeLV) occurs in nature not as a single genomic species but as a family of closely related viruses. The disease outcome of natural FeLV infection is variable and likely reflects genetic variation both in the virus and the naturally outbreeding host population. A series of studies have been undertaken with the objectives of examining natural FeLV genetic variation, the selective pressures operative in FeLV infection that lead to predominance of natural variants, and the consequences for in… Show more

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Cited by 20 publications
(21 citation statements)
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“…There are hundreds of endogenous CrERVs in each deer genome; moreover, the deer cells used in the coculture were different from those we analyzed previously. We cannot exclude that recombination events between several endogenous CrERVs were involved in the generation of CrERV-IND, similar scenario was described for several other ERVs (Anai et al, 2012;Levy, 2008;Shimode et al, 2015;Young et al, 2012). Interestingly, although we analyzed only a few CrERV genomes, there seems to be a trend towards higher degree of purifying selection in gag and pro/pol than in env.…”
Section: Discussionmentioning
confidence: 65%
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“…There are hundreds of endogenous CrERVs in each deer genome; moreover, the deer cells used in the coculture were different from those we analyzed previously. We cannot exclude that recombination events between several endogenous CrERVs were involved in the generation of CrERV-IND, similar scenario was described for several other ERVs (Anai et al, 2012;Levy, 2008;Shimode et al, 2015;Young et al, 2012). Interestingly, although we analyzed only a few CrERV genomes, there seems to be a trend towards higher degree of purifying selection in gag and pro/pol than in env.…”
Section: Discussionmentioning
confidence: 65%
“…ERV genomes can recombine among different endogenous loci or with related exogenous retroviruses. This can lead to the generation of fully infectious virus from two defective ERV genomes, or to the altered properties, for example altered tropism, of the exogenous partner involved in the recombination (Anai et al, 2012;Levy, 2008;Paprotka et al, 2011;Shimode et al, 2015;Young et al, 2012). In addition, through recombination with cellular genes, ERVs can form acutely transforming retroviruses (Kozak, 2015).…”
Section: Introductionmentioning
confidence: 99%
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“…At least two explanations are proposed to explain why some amino acids are mutated more frequently than the others, namely, the "hotspot" sites sensitive to endogenous and exogenous mutagens [22,23], and the disruption of protein functions dependent upon the mutation position in a protein [24,25]. However, the mutation patterns based on them are difficult to model, which loses the meaning of generalization.…”
Section: Discussionmentioning
confidence: 99%
“…Such variation has led to four naturally occurring FeLV subgroups, designated A, B, C, and T, that are distinguished genetically by sequence differences in the surface glycoprotein gene (SU) and functionally by interaction with distinct host cell receptors for entry. The weakly pathogenic FeLV subtype A (FeLV-A) is thought to represent the predominant agent spread horizontally cat-to-cat in nature, from which FeLV-B, -C and -T arise de novo in the infected animal by envelope ( env ) gene recombination, mutation or insertion events (Levy, 2008; Overbaugh and Bangham, 2001). While FeLV-A is associated with prolonged asymptomatic infection in the cat that may lead to malignant disease, typically a T-cell lymphoma of the thymus (Neil et al, 1991; Rezanka, Rojko, and Neil, 1992), the FeLV-B, -C and -T subgroups facilitate and/or redirect disease outcome to lymphoma, anemia or immunodeficiency disease, respectively (Levy, 2008; Overbaugh and Bangham, 2001).…”
Section: Introductionmentioning
confidence: 99%