Advances in transcutaneous vaccine delivery: Do all ways lead to Rome?

Bal, Suzanne M.; Ding, Zhi; Riet, Elly van; Jiskoot, Wim; Bouwstra, Joke A.

doi:10.1016/j.jconrel.2010.09.018

Cited by 178 publications

(150 citation statements)

References 260 publications

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“…The spaces between the cells are reported to be 50-70 nm (14). Therefore, the solid drug particles that are approximately the same size as the spaces between the cells, pass through the space and into peripheral blood vessels (15). Thus, nanocrystals improve bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Enhanced percutaneous absorption of cilostazol nanocrystals using aqueous gel patch systems and clarification of the absorption mechanism

2018

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Abstract. Cilostazol (CLZ), an anti-platelet agent, is primarily used following the onset of cerebral infarction. However, as CLZ is only marginally soluble in water, a strategy for patients with serious secondary conditions, such as impaired consciousness or aphagia, is required. In the present study, topical formulations containing CLZ nanocrystals (CLZ nano ) were designed to enhance percutaneous absorption. In addition, the mechanism of penetration of CLZ nano through rat skin was investigated. A topical formulation containing CLZ nanoparticles (CLZ nano gel patch) was prepared using a combination of recrystallization and ball milling of an aqueous gel. The particle size of CLZ nano was 74.5±6.2 nm (mean ± standard deviation). The concentration of permeated CLZ nano and penetration mechanism of the nanocrystals were measured in a percutaneous absorption experiment. The amount of penetrated CLZ, the penetration rate (J c ), the penetration coefficient through the skin (K p ) and the skin/preparation partition coefficient (K m ) for the CLZ nano gel patch were all significantly higher than those of the CLZ powder (CLZ micro ) gel patch, the CLZ nano ointment and the CLZ micro ointment. In in vitro percutaneous penetration experiments on the CLZ nano gel patches, there was a positive correlation between the number of CLZ nano . Following the application of the CLZ nano gel patch on rat skin, 98% of penetrated CLZ was observed in nanoparticle form; for the CLZ micro gel patch, this figure was 9%. In addition, the CLZ concentrations in the plasma of rats administered the CLZ nano gel patches were significantly higher than those of rats administered the CLZ nano CP gel and PEG ointments. It was suggested that CLZ nano (diameter <100 nm) were transferred through the intracellular spaces in the skin and then into peripheral blood vessels. To the best of our knowledge, this is the first report to elucidate the mechanism of the percutaneous penetration of nanocrystal medicines.

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Section: Introductionmentioning

confidence: 99%

Enhanced percutaneous absorption of cilostazol nanocrystals using aqueous gel patch systems and clarification of the absorption mechanism

2018

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“…To this end, reversible barrier disruption methods are often applied, such as chemical permeation enhancers, abrasion, electroporation, micro-needles, PowderJect and gene gun. 2 In contrast, TF vaccination aims to deliver antigens to the abundant peri-follicular APCs without compromising the SC barrier function. 3 Nanoparticles (NPs) have been shown to be ideal vehicles for TF delivery, since they preferentially accumulate and penetrate deeper into hair follicles than conventional formulations.…”

Section: Introductionmentioning

confidence: 99%

Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation

Mittal

Schulze

Ebensen

et al. 2015

Nanomedicine: Nanotechnology, Biology and Medicine

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In vaccine development, activating the immune system is the major challenge. In this perspective, transcutaneous immunization (TCI) offers an attractive approach due to the presence of abundant antigen presenting cells (APCs) such as Langerhans cells and dendritic cells. In particular transfollicular vaccination aims to deliver antigens to the abundant perifollicular APCs without compromising the SC barrier function. The present work clearly demonstrates the potential of transfollicular immunization as an approach to deliver antigens across intact skin following co-administration of nanoparticles with an adjuvant on intact skin as well as stimulating and modulating efficient humoral and cellular immune response according to the specific clinical needs. Conflict of interest:Claus Prior presentations:Parts of this study were presented on international conferences as listed below. There is no conflict of copy rights with these abstracts or proceedings.

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“…Diffusion models usually focus on the SC since, though it is the thinnest layer at most locations of diffusion interest, it presents the highest resistance to transport and is, therefore, rate limiting for most solutes [8,9]. Beneath the SC is the location of the epidermis, which thickness ranges from 130 to 180 μm and finally, as one penetrates the skin, one founds the dermis, filled with complex structures such as the nerves, blood vessels, nociceptors, lymph vessels, hair follicles and sweat glands [10,11], as schematized in Fig. 1.…”

Section: Introductionmentioning

confidence: 99%

Dermic diffusion and stratum corneum: A state of the art review of mathematical models

Couto

Fernandes

Cordeiro

et al. 2014

Journal of Controlled Release

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A B S T R A C TTransdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives.

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Advances in transcutaneous vaccine delivery: Do all ways lead to Rome?

Cited by 178 publications

References 260 publications

Enhanced percutaneous absorption of cilostazol nanocrystals using aqueous gel patch systems and clarification of the absorption mechanism

Enhanced percutaneous absorption of cilostazol nanocrystals using aqueous gel patch systems and clarification of the absorption mechanism

Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation

Dermic diffusion and stratum corneum: A state of the art review of mathematical models

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