Advances in the Understanding of EBV Associated Lymphoproliferative Disorders

Magrath, I. T.; Rowe, Martin; Filipovich, A. H.; Shapiro, R. S.; Su, Ih‐Jen; Sculley, T. B.

doi:10.1007/978-1-4612-0405-3_38

Epstein-Barr Virus and Human Disease • 1990 1991

DOI: 10.1007/978-1-4612-0405-3_38

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Advances in the Understanding of EBV Associated Lymphoproliferative Disorders

I. T. Magrath

Martin Rowe

A. H. Filipovich³

et al.

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1992

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Cited by 3 publications

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“…4,5 Compared with lymphomas occurring in nontransplant patients, PTLD has less favorable histologic features, a more aggressive clinical course, a smaller likelihood of response to conventional chemotherapy, and a poorer outcome. 6 PTLD is a difficult disease to deal with, especially in children, mostly because of the lack of knowledge about the clinical course and children's response to conventional interventions. Most published series comprise adult patients with many different primary diseases who have received a variety of transplant types and been treated with different immunosuppressive drugs.…”

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More Benign Lymphoproliferative Disease after Liver Transplant in Infants

et al. 2013

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CONTEXT-Despite the high frequency of liver transplants in infants, few data are available on the characteristics of posttransplant lymphoproliferative disorders in liver transplant patients (PTLD). OBJECTIVE-To analyze special features and behavior of PTLD arising after liver transplant in infants. METHODS-A comprehensive search of the literature was conducted for the available data on PTLD in infant liver transplant recipients through PubMed and Google scholar. An infant was defined as a liver recipient who was less than 2 years old at the time of transplant. Overall, 205 cases of PTLD were found in 24 reports, and the 100 infants with PTLD were compared with children and adults with PTLD. RESULTS-PTLD lesions in infants were more likely to be polymorphic whereas monomorphic lesions were more prevalent among older patients (P= .05). Remission rates, metastasis frequency, and organ involvement did not differ significantly between the groups. Survival analysis showed that the infants had a significantly better outcome than did older patients (P= .05). CONCLUSION-PTLD is more benign and may have a better outcome in infant liver transplant recipients than in older recipients. A prospective multicenter approach is needed for future research studies.

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More Benign Lymphoproliferative Disease after Liver Transplant in Infants

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Lymphoma resembling hodgkin disease after posttransplant lymphoproliferative disorder in a liver transplant recipient

Nalesnik

Randhawa

Demetris

et al. 1993

Cancer

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Background. Posttransplant Epstein‐Barr virus (EBV)‐associated lymphoproliferative disorders (PTLD) are B‐cell derived tumors of polymorphic to monomorphic histologic type. Hodgkin disease (HD) is not considered part of this spectrum and rarely occurs in the posttransplant population. A liver allograft recipient is reported who had a PTLD develop that resolved after a reduction of immunosuppression. Several years later, the patient had a separate lymphoid tumor develop that resembled HD. The relationship between the two proliferations is analyzed. Methods. Specimens were analyzed for T‐ and B‐cell rearrangements and EBV status by Southern blot hybridization. Immunoperoxidase studies were performed to determine the phenotypic status of the lesions. In situ hybridization for EBV early RNA (EBER) was done to determine the distribution of virus‐positive cells in tissue sections. Results. Unique clonal rearrangements of immunoglobulin genes and EBV were seen in each instance. No evidence of T‐cell receptor rearrangement was observed. EBER positivity was widespread in the PTLD and largely, but not exclusively, limited to the anaplastic cell in the HD‐like tumor. The phenotype of these anaplastic cells was similar to that described for Reed‐Sternberg (RS) cells. Conclusion. The two tumors are unique B‐cell growths associated with separate clones of lymphocytes carrying episomal EBV. Patients with PTLD may be at risk for the continued development of EBV‐associated disorders. Lymphomas resembling HD represent one possible manifestation of this risk.

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Epstein-Barr virus infection and associated diseases in children

Schuster

Kreth

1992

Eur J Pediatr

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Epstein-Barr virus (EBV), an ubiquitous human B lymphotropic virus, is the cause of infectious mononucleosis. Moreover, EBV infection can be followed by lymphoproliferative diseases in patients with inherited and acquired immunodeficiencies. Primary EBV infection may be a threat to all children after marrow or organ transplantation or those receiving chronic immunosuppressive treatment for various other reasons. The virus has been also implicated in the pathogenesis of different malignant tumours such as Burkitt lymphoma, nasopharyngeal carcinoma, Hodgkin disease and some T-cell lymphomas. This review focuses on various aspects of virus-host interactions, immune mechanisms of the host, and the still experimental therapeutic approaches in EBV-associated diseases.

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Advances in the Understanding of EBV Associated Lymphoproliferative Disorders

Cited by 3 publications

References 16 publications

More Benign Lymphoproliferative Disease after Liver Transplant in Infants

More Benign Lymphoproliferative Disease after Liver Transplant in Infants

Lymphoma resembling hodgkin disease after posttransplant lymphoproliferative disorder in a liver transplant recipient

Epstein-Barr virus infection and associated diseases in children

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