Advances in the Treatment of Metastatic Colorectal Cancer

Goldberg, Richard M.

doi:10.1634/theoncologist.10-90003-40

Cited by 84 publications

(41 citation statements)

References 45 publications

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“…A median survival of 29 months is far superior to the best 2 nd line palliative chemotherapy regimens, which report a median survival of 20 months (14,15). The overall three year survival rate of 40% is comparable to results…”

Section: Survivalmentioning

confidence: 74%

Microwave ablation for unresectable hepatic tumours: Clinical results using a novel microwave probe and generator

Bhardwaj

Strickland

Ahmad

et al. 2010

European Journal of Surgical Oncology (EJSO)

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Section: Survivalmentioning

confidence: 74%

Microwave ablation for unresectable hepatic tumours: Clinical results using a novel microwave probe and generator

Bhardwaj

Strickland

Ahmad

et al. 2010

European Journal of Surgical Oncology (EJSO)

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“…Colorectal cancer (CRC) is the third most prevalent for m of cancer in men and women, with a 5-year survival rate of 63%, decreasing to 10% in patients with metastatic disease [1] . More than 80% of colorectal neoplasms occur sporadically, arising from adenomatous polyps via the long-term accumulation of mutations in genes including APC, K-ras and TP53 [2] .…”

Section: Introductionmentioning

confidence: 99%

Role of probiotics, prebiotics and synbiotics in chemoprevention for colorectal cancer

Fotiadis

Stoidis²,

Spyropoulos³

et al. 2008

WJG

153

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Colorectal cancer is the third most common form of cancer. Current treatments are all associated with a high risk of complications and a low success rate. Recently, synbiotics have been proposed as a new preventive and therapeutic option. There is no direct experimental evidence for cancer suppression in humans as a result of the consumption of pro-, preor synbiotics. However, there is a wealth of evidence emerging from laboratory studies. The mechanisms by which pro-, pre-and synbiotics may inhibit colon cancer are now beginning to be understood and will be addressed in the present review.

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“…Colorectal cancer (CRC) is the third most prevalent form of cancer in men with a 5-year survival rate of 63%, decreasing to 10% in patients with metastatic disease (Goldberg, 2005). The diet makes an important contribution to CRC risk implying that risks are potentially reducible (Rafter, 2004).…”

mentioning

confidence: 99%

Effects of a probiotic in combination with prebiotics on intestinal lactobacilli and coliforms and activities of bacterial enzymes in 1,2-dimethylhydrazine exposed rats

Strojný¹,

Bomba²,

Hijová³

et al. 2011

Czech J. Anim. Sci.

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The intestinal microflora plays a crucial role in the health of humans and animals. All functions of the absorption of nutrients are connected with the valid digestive tract. Approximately 70% of the immune function is derived from the gut, being composed of the mucosal barrier, submucosal glands and the mucosa-associated lymphoid tissue (Bengmark, 2002 ABSTRACT: Effects of the probiotic (PRO) Lactobacillus plantarum and of the combination of PRO and the prebiotic (PRE) inulin enriched with oligofructose (2%), and PRO with Lini oleum virginale (O) on counts of lactobacilli and coliforms and enzymatic activities in faeces of rats were studied. The rats (n = 60) were divided into 5 groups of 12 subjects. The animals were fed on a high fat diet (10%) for 8 weeks of experiment. Colon cancer was induced by the application of 1,2-dimethylhydrazine (DMH) twice a week in a dose of 20 mg/kg s.c. in groups G2-G5. The rats in group 1 (control 1) received a diet without any supplements. The rats in group 2 (control 2) received 1,2 DMH without any supplements. The rats in group 3 received PRO, group 4 PRO and PRE, and group 5 received PRO and O. A significant decrease (P < 0.05) of coliforms was found out after the application of PRO, PRO-O, and PRO-PRE in comparison with control group G2. Significantly higher (P < 0.05) counts of lactobacilli were determined after the application of PRO-O and PRO-PRE. Significantly lower (P < 0.001) activities of β-galactosidase, β-glucuronidase and α-glucosidase were observed in PRO, PRO-PRE and PRO-O, while in the case of the enzyme β-glucosidase the activity was lower only after the addition of PRO-O. The protective effect of lactobacilli was observed in the order PRO-O, PRO-PRE, and PRO. It was shown that combinations of PRO-O and PRO-PRE had a synergistic effect which was higher than the effect of administering only PRO.

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Advances in the Treatment of Metastatic Colorectal Cancer

Cited by 84 publications

References 45 publications

Microwave ablation for unresectable hepatic tumours: Clinical results using a novel microwave probe and generator

Microwave ablation for unresectable hepatic tumours: Clinical results using a novel microwave probe and generator

Role of probiotics, prebiotics and synbiotics in chemoprevention for colorectal cancer

Effects of a probiotic in combination with prebiotics on intestinal lactobacilli and coliforms and activities of bacterial enzymes in 1,2-dimethylhydrazine exposed rats

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