Advances in the treatment of atherosclerosis with ligand‐modified nanocarriers

Deng, Xiujiao; Wang, Jinghao; Yu, Shanshan; Tan, Suiyi; Yu, Tingting; Xu, Qiaxin; Chen, Nenghua; Zhang, Siqi; Zhang, Ming‐Rong; Hu, Kuan; Xiao, Zeyu

doi:10.1002/exp.20230090

Cited by 6 publications

(3 citation statements)

References 215 publications

(291 reference statements)

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“…More novel concepts for the design and advancement of MB ApoB100 are needed for nanomedicines specifically tailored for the treatment of atherosclerosis. 46 Moreover, the acoustic parameters also need to be optimized to decrease the potential risk of UTMD. Nonetheless, our study provides a novel approach for reducing LDL-C levels for hypercholesterolemia-related conditions by using UTMD combined with MB ApoB100 .…”

Section: Discussionmentioning

confidence: 99%

“…Although a significantly reduced LDL-C level in circulation and enhanced inhibition effects against atherosclerotic plaque growth could be achieved through UTMD combined with MB ApoB100 , we must mention that there is still a long way to go to translate this technology to clinical application due to the presence of avidin in MB ApoB100 . More novel concepts for the design and advancement of MB ApoB100 are needed for nanomedicines specifically tailored for the treatment of atherosclerosis . Moreover, the acoustic parameters also need to be optimized to decrease the potential risk of UTMD.…”

Section: Discussionmentioning

confidence: 99%

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Acoustic Delivery of Plasma Low-Density Lipoprotein into Liver via ApoB100-Targeted Microbubbles Inhibits Atherosclerotic Plaque Growth

Li,

Zhou,

Lai

et al. 2024

ACS Appl. Mater. Interfaces

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Atherosclerosis is the main risk factor for cardiovascular disease, which accounts for the majority of mortality worldwide. A significantly increased plasma level of low-density lipoprotein cholesterol (LDL-C), surrounded by a monolayer of phospholipids, free cholesterol, and one apolipoprotein B-100 (ApoB-100) in the blood, plays the most significant role in driving the development of atherosclerosis. Commercially available cholesterol-lowering drugs are not sufficient for preventing recurrent cardiovascular events. Developing alternative strategies to decrease the plasma cholesterol levels is desirable. Herein, we develop an approach for reducing LDL-C levels using gas-filled microbubbles (MBs) that were coated with anti-ApoB100 antibodies. These targeted MB ApoB100 could selectively capture LDL particles in the bloodstream through forming LDL-MB ApoB100 complexes and transport them to the liver for degradation. Further immunofluorescence staining and lipidomic analyses showed that these LDL-MB ApoB100 complexes may be taken up by Kupffer cells and delivered to liver cells and bile acids, greatly inhibiting atherosclerotic plaque growth. More importantly, ultrasound irradiation of these LDL-MB ApoB100 complexes that accumulated in the liver may induce acoustic cavitation effects, significantly enhancing the delivery of LDL into liver cells and accelerating their degradation. Our study provides a strategy for decreasing LDL-C levels and inhibiting the progression of atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acoustic Delivery of Plasma Low-Density Lipoprotein into Liver via ApoB100-Targeted Microbubbles Inhibits Atherosclerotic Plaque Growth

Li,

Zhou,

Lai

et al. 2024

ACS Appl. Mater. Interfaces

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“…The fibrous cap gradually becomes thinner and evolves into unstable plaques [11]. The treatment of atherosclerosis is mainly based on etiological treatment [12][13][14][15]. For example, statins interfere with atherosclerosis by lowering blood lipid levels [16,17].…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant Dendrobium officinale Polysaccharide Modulates Host Metabolism and Gut Microbiota to Alleviate High-Fat Diet-Induced Atherosclerosis in ApoE−/− Mice

Qi,

Zhou,

Wang

et al. 2024

Antioxidants

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Background: The discovery of traditional plants’ medicinal and nutritional properties has opened up new avenues for developing pharmaceutical and dietary strategies to prevent atherosclerosis. However, the effect of the antioxidant Dendrobium officinale polysaccharide (DOP) on atherosclerosis is still not elucidated. Purpose: This study aims to investigate the inhibitory effect and the potential mechanism of DOP on high-fat diet-induced atherosclerosis in Apolipoprotein E knockout (ApoE−/−) mice. Study design and methods: The identification of DOP was measured by high-performance gel permeation chromatography (HPLC) and Fourier transform infrared spectroscopy (FTIR). We used high-fat diet (HFD)-induced atherosclerosis in ApoE−/− mice as an animal model. In the DOP intervention stage, the DOP group was treated by gavage with 200 μL of 200 mg/kg DOP at regular times each day and continued for eight weeks. We detected changes in serum lipid profiles, inflammatory factors, anti-inflammatory factors, and antioxidant capacity to investigate the effect of the DOP on host metabolism. We also determined microbial composition using 16S rRNA gene sequencing to investigate whether the DOP could improve the structure of the gut microbiota in atherosclerotic mice. Results: DOP effectively inhibited histopathological deterioration in atherosclerotic mice and significantly reduced serum lipid levels, inflammatory factors, and malondialdehyde (F/B) production. Additionally, the levels of anti-inflammatory factors and the activity of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), were significantly increased after DOP intervention. Furthermore, we found that DOP restructures the gut microbiota composition by decreasing the Firmicutes/Bacteroidota (F/B) ratio. The Spearman’s correlation analysis indicated that serum lipid profiles, antioxidant activity, and pro-/anti-inflammatory factors were associated with Firmicutes, Bacteroidota, Allobaculum, and Coriobacteriaceae_UCG-002. Conclusions: This study suggests that DOP has the potential to be developed as a food prebiotic for the treatment of atherosclerosis in the future.

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Engineering Nanoplatforms for Theranostics of Atherosclerotic Plaques

Liu,

Jiang,

Yang

et al. 2024

Adv Healthcare Materials

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Atherosclerotic plaque formation is considered the primary pathological mechanism underlying atherosclerotic cardiovascular diseases, leading to severe cardiovascular events such as stroke, acute coronary syndromes, and even sudden cardiac death. Early detection and timely intervention of plaques are challenging due to the lack of typical symptoms in the initial stages. Therefore, precise early detection and intervention play a crucial role in risk stratification of atherosclerotic plaques and achieving favorable post‐interventional outcomes. The continuously advancing nanoplatforms have demonstrated numerous advantages including high signal‐to‐noise ratio, enhanced bioavailability, and specific targeting capabilities for imaging agents and therapeutic drugs, enabling effective visualization and management of atherosclerotic plaques. Motivated by these superior properties, we comprehensively summarize various noninvasive imaging modalities for early recognition of plaques in the preliminary stage of atherosclerosis. Additionally, we propose several therapeutic strategies to enhance the efficacy of treating atherosclerotic plaques. Finally, we discuss existing challenges and promising prospects for accelerating clinical translation of nanoplatform‐based molecular imaging and therapy for atherosclerotic plaques. In conclusion, this review provides an insightful perspective on the diagnosis and therapy of atherosclerotic plaques.This article is protected by copyright. All rights reserved

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Advances in the treatment of atherosclerosis with ligand‐modified nanocarriers

Cited by 6 publications

References 215 publications

Acoustic Delivery of Plasma Low-Density Lipoprotein into Liver via ApoB100-Targeted Microbubbles Inhibits Atherosclerotic Plaque Growth

Acoustic Delivery of Plasma Low-Density Lipoprotein into Liver via ApoB100-Targeted Microbubbles Inhibits Atherosclerotic Plaque Growth

The Antioxidant Dendrobium officinale Polysaccharide Modulates Host Metabolism and Gut Microbiota to Alleviate High-Fat Diet-Induced Atherosclerosis in ApoE−/− Mice

Engineering Nanoplatforms for Theranostics of Atherosclerotic Plaques

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