Advances in the treatment of patients with gastric adenocarcinoma

Foukakis, Theodoros; Lundell, Lars; Gubanski, Michael; Lind, Pehr

doi:10.1080/02841860701218634

Cited by 48 publications

(33 citation statements)

References 64 publications

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“…Furthermore, the treatment outcome remains unsatisfactory as early diagnosis of gastric cancer remains difficult and most patients have already developed metastatic lesions when diagnosed (1). Therefore, it is necessary to search novel agents to treat stomach cancer patients with adverse effects.…”

Section: Introductionmentioning

confidence: 99%

RRR-α-tocopheryl succinate induces apoptosis in human gastric cancer cells via the NF-κB signaling pathway

et al. 2014

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Abstract.To investigate the effects of the nuclear factor (NF)-κB signaling pathway on the induction of apoptosis by vitamin E succinate (RRR-α-tocopheryl succinate; VES) in human gastric carcinoma cells. Human gastric carcinoma SGC-7901 cells were treated with temperate concentrations of VES and pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-κB. Cell viability and apoptosis were respectively estimated by methylthiazol tetrazolium (MTT) assay and the Annexin V-FITC method. Western blot analysis was used to evaluate the protein expressions of NF-κBp65 and Bcl-2 family members Bcl-2, Bax and cleavage of caspase-3, caspase-9, and poly (ADP-ribose) polymerase (PARP). The DNA-binding activity of NF-κBp65 was measured by electrophoretic mobility shift assay (EMSA). Reverse transcription and polymerase chain reaction (RT-PCR) was implemented to evaluate the transcription of inhibitor of apoptosis (IAP) genes. Apoptosis assessment showed that VES induces apoptotic cell death in human gastric carcinoma cells. In the following experiments, PDTC (100 µM) was used in cell treatment 2 h before VES. The decreased ratio of the nuclear and cytosolic NF-κBp65 protein level was induced by VES and PDTC reinforced this trend. PDTC treatment significantly enhanced the decrease of NF-κB-DNA binding activity induced by VES in human gastric SGC-7901. The decrease in protein expression of Bcl-2 as well as the increase in the protein expression of Bax were induced by VES treatment. The cleavage of caspase-9, caspase-3 and PARP was induced. There was no effect on the gene transcription of c-IAP-1, c-IAP-2, and x-linked IAP (XIAP) compared with the control group, whereas mRNA levels of survivin and the neuronal apoptosis inhibitory protein (NAIP) markedly decreased. Notably, pretreatment with PDTC reinforced all the above VES-induced effects. In conclusion, VES-induced apoptosis in SGC-7901 cells is accompanied by the inhibition of the NF-κB signaling pathway, including changes in Bcl-2 family members, cleavage of caspases and gene transcription of survivin and NAIP.

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Section: Introductionmentioning

confidence: 99%

RRR-α-tocopheryl succinate induces apoptosis in human gastric cancer cells via the NF-κB signaling pathway

et al. 2014

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“…2004) [15]. However, due to high rates of local recurrence, more than half of the patients with early gastric cancers remain uncured [16]. In these cases, preoperative evaluation of prognostic factors is important.…”

Section: Discussionmentioning

confidence: 99%

Snail Protein Expression as a Hallmark of Gastric Carcinoma in Biopsy Samples

et al. 2012

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Overexpression of the Snail gene transcriptional repressor promotes an epithelial-to-mesenchymal transition (EMT) in epithelial tumor cell lines. In this study, we aimed to determine the correlation between Snail protein expression and clinicopathological features and to test whether Snail can be used as a marker to distinguish gastric carcinomas from benign tissues in biopsy samples. The results of immunohistochemistry with an antibody against Snail showed that most adenocarcinomas had positive Snail expression, whereas weak Snail expression was detected in a small number of gastritis and gastric adenomas. Snail-positive cells were detected in the stroma as well as in the glandular epithelium in some adenocarcinomas. In addition to Snail immunostaining, immunostaining of the EMT-related molecules, E-cadherin and vimentin, was performed. E-cadherin was not detected in adenocarcinomas that expressed Snail, whereas gastritis and adenomas stained positively for E-cadherin. Vimentin expression was seen in adenocarcinomas with positive Snail expression, whereas gastritis and adenomas did not express vimentin. In conclusion, we propose that Snail is a useful biomarker to distinguish gastric adenocarcinomas from benign lesions in biopsy samples.

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“…The 2-year DFS with bi-weekly carboplatin plus paclitaxel in patients with stage IB-IIIB completely resected NSCLC was previously reported to be 89.0% (17 , OSAMU KAWANO 1 and RYOICHI NAKANISHI S-1 ( Ta i ho Pha r maceutica l Co., Ltd., Tokyo, Japan) is an oral anticancer agent comprising tegafur, 5-chloro-2, 4-dihydroxypyridine and potassium oxonate, in a molar ratio of 1:0.4:1 (18), which has achieved the highest response rate among several oral anticancer agents against unresectable advanced carcinomas in phase II studies (19). Postoperative S-1 chemotherapy is one of the standard therapies for gastric cancer in the US, Europe and Japan (20,21). Several clinical trials for NSCLC using S-1 chemotherapy and S-1 + platinum-based chemotherapy have been conducted, with largely favorable findings (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

S-1 vs. paclitaxel plus carboplatin as adjuvant chemotherapy for completely resected stageï¿½II/IIIA non‑small‑cell lung cancer

et al. 2017

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Abstract.The majority of patients with completely resected stage II or IIIA non-small-cell lung cancer (NSCLC) require adjuvant chemotherapy to improve survival following surgery. In the present trial, the 2-year disease-free survival (DFS), and the feasibility and safety of S-1 as an adjuvant chemotherapy for advanced lung cancer were evaluated. A total of 40 patients with completely resected stage II or IIIA NSCLC were enrolled and randomized to receive postoperative chemotherapy with either up to 4 cycles of paclitaxel plus carboplatin (arm A) or with up to 1 year of S-1 (arm B). The primary endpoint was 2-year DFS. The secondary endpoints were feasibility and toxicity. A total of 40 patients were enrolled, but 3 were excluded in accordance with the exclusion criteria. The remaining 37 patients were analyzed. The 2-year DFS rate was 54.2% in arm A and 84.2% in arm B. Overall, 15/18 (83.3%) patients completed 4 cycles of paclitaxel plus carboplatin and 13/19 (68.4%) completed 1-year of S-1adjuvant chemotherapy. Of the 18 (16.7%) patients in arm A, 3 experienced grade 3 or 4 adverse events, while none in arm B experienced such events. Therefore, S-1 chemotherapy for patients with completely resected stage II or IIIA NSCLC was a feasible and safe regimen, and it may therefore be considered as a potential adjuvant chemotherapy option for advanced NSCLC.

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Advances in the treatment of patients with gastric adenocarcinoma

Cited by 48 publications

References 64 publications

RRR-α-tocopheryl succinate induces apoptosis in human gastric cancer cells via the NF-κB signaling pathway

RRR-α-tocopheryl succinate induces apoptosis in human gastric cancer cells via the NF-κB signaling pathway

Snail Protein Expression as a Hallmark of Gastric Carcinoma in Biopsy Samples

S-1 vs. paclitaxel plus carboplatin as adjuvant chemotherapy for completely resected stageï¿½II/IIIA non‑small‑cell lung cancer

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