Advances in the Synthesis of Heteroaromatic Hybrid Chalcones

Abstract

Chalcones continue to occupy a venerated status as scaffolds for the construction of a variety of heterocyclic molecules with medicinal and industrial properties. Syntheses of hybrid chalcones featuring heteroaromatic components, especially those methods utilizing green chemistry principles, are important additions to the preparative methodologies for this valuable class of molecules. This review outlines the advances made in the last few decades toward the incorporation of heteroaromatic components in the construction of hybrid chalcones and highlights examples of environmentally responsible processes employed in their preparation.

Design, Synthesis, and Antifungal Activities of Novel Carboxamides Derivatives Bearing a Chalcone Scaffold as Potential SDHIs

“…[17] Numerous studies have been conducted to explore the structures of chalcones to obtain more drug and pesticide candidates based on molecular hybridization, which is a common and useful strategy. [26][27][28][29] In this work, a series of novel pyrazole-4-carboxamides 5 a-5 l, 8 a, 8 b and 11 containing a chalcone scaffold were designed and synthesized based on molecular hybridization (Figure 2). Subsequently, in vitro antifungal activities of these target compounds against five plant pathogenic fungi (Rhizoctoinia solani; Sclerotinia sclerotiorum; Botrytis cinerea; Fusarium graminearum; and Alternaria alternate.)…”

“…Moreover, some chalcone derivatives such as metochalcone and sofalcone have been clinically approved due to their convenient synthesis, outstanding bioactivities, and low toxicity (Figure 2). [17] Numerous studies have been conducted to explore the structures of chalcones to obtain more drug and pesticide candidates based on molecular hybridization, which is a common and useful strategy [26–29] . In this work, a series of novel pyrazole‐4‐carboxamides 5 a – 5 l , 8 a , 8 b and 11 containing a chalcone scaffold were designed and synthesized based on molecular hybridization (Figure 2).…”