Advances in the Study of Circadian Genes in Non-Small Cell Lung Cancer

Zhang, Hao; Liu, Renwang; Zhang, Bo; Huo, Huandong; Song, Zuoqing

doi:10.1177/15347354221096080

Cited by 8 publications

(4 citation statements)

References 62 publications

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“…Hence, biological rhythm dysregulation may lead to abnormal cell proliferation, cell resistance to apoptosis, and increased gene mutation rates, which may induce tumorigenesis (19). Further studies have shown that changes in biological rhythms are closely related to the occurrence of thyroid, breast, prostate, colorectal, liver, lung, and other cancers (20)(21)(22)(23). At the mammalian cell level, the circadian rhythm system is a transcriptional translation feedback loop based on the oscillatory compilation of circadian clock gene expression (24,25) and involves 14 core circadian clock genes as well as various circadian clock control genes.…”

Section: W I T H D R a W N S E E M A N U S C R I P T D O I F O R D E ...mentioning

confidence: 99%

WITHDRAWN: Period2-mediated downregulation of ERK/MAPK phosphorylation in nasopharyngeal carcinoma

Zhang,

Ma,

Kang

et al. 2023

Preprint

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PurposePeriod2 (PER2) is associated with the occurrence and development of nasopharyngeal carcinoma (NPC); however, its mechanism(s) of action underlying NPC carcinogenesis remains unclear.MethodIn this study, differentially expressed proteins were identified via proteomics. The cells were infected with Lentivirus and divided into two groups: normal control group (Control) andPER2overexpression Lentivirus-infected group (PER2-OE). Western blot was used to detect ERK and p-ERK expression in the two groups. Immunohistochemistry was used to further detect PER2 and p-ERK expression in human NPC samples, and the correlations between PER2, p-ERK and clinical NPC characteristics were analysed. Result: Statistical analysis revealed that MAPK3 (ERK) was among the top 20 differentially expressed proteins, PER2overexpression and control samples were significantly different (P<0.05). The western blot results showed thatPER2overexpression downregulated p-ERK protein expression. Significant differences (P < 0.05) were observed in the proportions of cells which expressed PER2 and p-ERK between NPC tissues and normal nasopharyngeal mucosa samples.ConclusionOverexpression ofPER2downregulated the expression of p-ERK. In NPC tissues, PER2 protein was expressed at low levels, whereas p-ERK protein was highly expressed, and these trends are closely related to the occurrence and development of NPC.

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Section: W I T H D R a W N S E E M A N U S C R I P T D O I F O R D E ...mentioning

confidence: 99%

WITHDRAWN: Period2-mediated downregulation of ERK/MAPK phosphorylation in nasopharyngeal carcinoma

Zhang,

Ma,

Kang

et al. 2023

Preprint

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“…Knockdown of BMAL1 disrupts circadian rhythm and enhances migration or invasion in lung cancer, breast cancer, and glioma cells (170, 171). Loss of BMAL1 may contribute to lung cancer development by activating KRAS and cancer-regulating genes such as P53 and c-Myc (172). Overexpression of BMAL1 inhibits proliferation and increases sensitivity to oxaliplatin in CRC cell lines and HCT116 cell models in vivo (174).…”

Section: Baml1mentioning

confidence: 99%

Circadian clock and lipid metabolism disorders: a potential therapeutic strategy for cancer

Liu,

Zhang,

Chen

et al. 2023

Front. Endocrinol.

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Recent research has emphasized the interaction between the circadian clock and lipid metabolism, particularly in relation to tumors. This review aims to explore how the circadian clock regulates lipid metabolism and its impact on carcinogenesis. Specifically, targeting key enzymes involved in fatty acid synthesis (SREBP, ACLY, ACC, FASN, and SCD) has been identified as a potential strategy for cancer therapy. By disrupting these enzymes, it may be possible to inhibit tumor growth by interfering with lipid metabolism. Transcription factors, like SREBP play a significant role in regulating fatty acid synthesis which is influenced by circadian clock genes such as BMAL1, REV-ERB and DEC. This suggests a strong connection between fatty acid synthesis and the circadian clock. Therefore, successful combination therapy should target fatty acid synthesis in addition to considering the timing and duration of drug use. Ultimately, personalized chronotherapy can enhance drug efficacy in cancer treatment and achieve treatment goals

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“…clock genes have been identified in mammals that possess homologous genes also found in Drosophila melanogaster [9]. However, two genes, Clock and Bmal1, have been shown to play a significant role in maintaining sleep homeostasis [10].…”

Section: Introductionmentioning

confidence: 99%

Ziwuliuzhu Acupuncture Modulates Clock mRNA, Bmal1 mRNA and Melatonin in Insomnia Rats

Huang

Xiao

Chen

et al. 2023

J Acupunct Meridian Stud

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Background: In clinics, Ziwuliuzhu acupuncture is widely considered an effective method of treating insomnia; however, there is currently limited information available regarding its possible mechanisms. Although the method of Ziwuliuzhu acupuncture possesses a unique rhythmic pattern. Objectives: In this study, we have creatively combined the traditional Chinese medicine of Ziwuliuzhu with a modern biological rhythm to investigate the internal mechanism of insomnia. Methods: Pathological tissue from the hypothalamus was analyzed using hematoxylineosin staining. The level of TNF (tumor necrosis factor)-α in the SCN (suprachiasmatic nucleus) area of the hypothalamus was detected in situ using the TUNEL fluorescence staining assay. The concentration of hypothalamic melatonin was detected using the enzyme-linked immunosorbent assay (ELISA). The mRNA expression of Clock and Bmal1 was measured using RT-qPCR. Results: In the Ziwuliuzhu acupuncture groups, the structural damage in the hypothalamic neurons was alleviated compared to the model group and the expression of inflammatory factors was reduced. The mRNA expression levels of Clock and Bmal1 were significantly increased (p < 0.05). The concentration of melatonin was significantly increased (p < 0.001). Although there were no significant differences between the treatment groups (diazepam group, Nazi group, Najia group, and routine group) (p > 0.05). Conclusion: Ziwuliuzhu acupuncture alleviated neuronal damage and modulated the inflammatory reaction in the hypothalamus of rats with insomnia. Moreover, Ziwuliuzhu acupuncture increased the expression levels of Clock and Bmal1 mRNA, and MT content. This study has potentially highlighted one of the mechanisms through which Ziwuliuzhu acupuncture can be used to treat insomnia.

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Advances in the Study of Circadian Genes in Non-Small Cell Lung Cancer

Cited by 8 publications

References 62 publications

WITHDRAWN: Period2-mediated downregulation of ERK/MAPK phosphorylation in nasopharyngeal carcinoma

WITHDRAWN: Period2-mediated downregulation of ERK/MAPK phosphorylation in nasopharyngeal carcinoma

Circadian clock and lipid metabolism disorders: a potential therapeutic strategy for cancer

Ziwuliuzhu Acupuncture Modulates Clock mRNA, Bmal1 mRNA and Melatonin in Insomnia Rats

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