Advances in the study of acetaminophen-induced liver injury

Li, Xinghui; Ni, Jiaqi; Chen, Li

doi:10.3389/fphar.2023.1239395

Cited by 3 publications

(1 citation statement)

References 107 publications

(105 reference statements)

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“…Sometimes, TPVB alone is far from sufficient for postoperative analgesia, and multimode analgesia strategies should be administered to fulfill the purpose of enhanced recovery. As a frequently used antipyretic and analgesic drug, acetaminophen is commonly used in combination with other kinds of analgesics for multimodal analgesia [ 26 ]. Paracetamol and mannitol injection (50 ml, 500 mg), the first injection dosage form of acetaminophen in China, provides the advantages of no first pass hepatic metabolism and rapid onset, and is assumed to be safer than oral acetaminophen.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of postoperative analgesia with intravenous paracetamol and mannitol injection, combined with thoracic paravertebral nerve block in post video-assisted thoracoscopic surgery pain: a prospective, randomized, double-blind controlled trial

Zhou,

Yuan,

Xing

et al. 2024

BMC Anesthesiol

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Background Although video-assisted thoracoscopic surgery (VATS) has advantages of reduced injury and faster healing, patients still endure moderate and severe postoperative pain. Paracetamol and mannitol injection, the first acetaminophen injection in China, has the advantages of convenient administration, rapid onset of action, and no first-pass effect. This aim of this study was to investigate the efficacy of postoperative analgesia with paracetamol and mannitol injection, combined with thoracic paravertebral nerve block (TPVB) in post VATS pain. Methods This study was a single-center, prospective, randomized, double-blind controlled clinical trial. Patients scheduled for VATS were randomly divided into three groups, general anesthesia group (Group C), TPVB group (Group T) and TPVB + paracetamol and mannitol injection group (Group TP). In this study, the primary outcome was determined as visual analog scale (VAS) scores at rest and coughing, the secondary observation outcomes were the first time to use analgesic pump, the total consumption of oxycodone in the analgesic pump, number of effective and total analgesic pump compressions at first 48 h postoperatively, the perioperative consumption of sufentanil, time to extubation, hospital length of stay, urine volume, and the incidence of adverse events. Results In a state of rest and cough, patients in the Group TP showed significantly lower VAS pain scores at 1, 12, 24, and 48 postoperative-hour compared with Group C and Group T. Intraoperative sufentanil and postoperative oxycodone consumption, the first time to press analgesic pump, the times of effective and total compressions of patient- controlled analgesia (PCA) were lower than those of the Group C and Group T. Interestingly, urine output was higher in Group TP. There were no differences between the three groups in terms of extubation time, length of hospital stay and adverse effects, indicating that intravenous paracetamol and mannitol injection is an effective and safe perioperative analgesia method. Conclusions Paracetamol and mannitol injection, combined with TPVB may provide important beneficial effects on acute pain control and reduce the consumption of opioid in patients undergoing VATS. Trial registration The trial was registered on Jun 19, 2023 in the Chinese Clinical Trial Registry (https://www.chictr.org.cn/showproj.html?proj=199315), registration number ChiCTR2300072623 (19/06/2023).

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Section: Discussionmentioning

confidence: 99%

Efficacy of postoperative analgesia with intravenous paracetamol and mannitol injection, combined with thoracic paravertebral nerve block in post video-assisted thoracoscopic surgery pain: a prospective, randomized, double-blind controlled trial

Zhou,

Yuan,

Xing

et al. 2024

BMC Anesthesiol

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A novel “ON-OFF-ON” colorimetric and fluorescence dual-signal sensing APAP based on TSPP-Fe3+

Ma,

Jia,

Shi

et al. 2024

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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pH-dependent interaction between acetaminophen and dioleoylphosphatidylcholine membranes

Ishikawa,

Nabika

2024

Chemistry Letters

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Acetaminophen may cause acute liver failure due to overdose. Understanding the processes of adsorption and incorporation of acetaminophen into cell membranes is crucial for elucidating the mechanisms of action and toxicity of acetaminophen. We investigated the interaction between acetaminophen and a model cell membrane (dioleoylphosphatidylcholine) using surface pressure–area isotherms. Acetaminophen was incorporated into the dioleoylphosphatidylcholine membrane under basic conditions, increasing the dioleoylphosphatidylcholine molecular area. The acetaminophen uptake was explained by the adsorption of hydroxide ions onto the lipid membrane and electrostatic interaction between acetaminophen and lipid molecules under basic conditions.

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Advances in the study of acetaminophen-induced liver injury

Cited by 3 publications

References 107 publications

Efficacy of postoperative analgesia with intravenous paracetamol and mannitol injection, combined with thoracic paravertebral nerve block in post video-assisted thoracoscopic surgery pain: a prospective, randomized, double-blind controlled trial

Efficacy of postoperative analgesia with intravenous paracetamol and mannitol injection, combined with thoracic paravertebral nerve block in post video-assisted thoracoscopic surgery pain: a prospective, randomized, double-blind controlled trial

A novel “ON-OFF-ON” colorimetric and fluorescence dual-signal sensing APAP based on TSPP-Fe3+

pH-dependent interaction between acetaminophen and dioleoylphosphatidylcholine membranes

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