“…8,15,35,36 Polyelectrolyte nanocomplexes (NCs) are an emerging class of polymeric nanoparticle drug carrier, and are formed through electrostatic interactions between oppositely charged polymers. 37,38 These NC drug carriers offer physicochemical tunability dependent on the polymer ratios, chemical structures, pKa's, and molecular weights. 37 NCs have further advantages in their ease of fabrication without specialized equipment, and in their high loading efficiencies of therapeutic cargos, especially for drugs of high charge densities, [38][39][40] which often have low encapsulation efficiencies using other polymeric systems.…”