Advances in the role and mechanism of lactic acid bacteria in treating obesity

Shen, Yilin; Zhang, Liu‐Qing; Yang, Ying; Yin, Bin‐Cheng; Ye, Bang‐Ce; Zhou, Ying

doi:10.1002/fbe2.12002

Cited by 20 publications

(11 citation statements)

References 80 publications

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“…Lactic acid bacteria can regulate lipid metabolism by modulating the structure and diversity of the gut microbiota [39]. The microbiota compositions of obese and lean individuals are different, and reduced microbial richness is often observed in obese individuals [40].…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum CCFM1180 attenuates obesity induced by estrogen deficiency by activating estrogen receptor alpha in abdominal adipose tissue and regulating gut microbiota-derived metabolites

Chen¹,

Mei²,

Guo³

et al. 2024

Food Science and Human Wellness

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Lipid metabolism disorders commonly occur during menopause. Estrogen deficiency has been shown to lead to excessive energy intake and abnormal lipid metabolism in ovariectomized rats, resulting in obesity. Probiotics exhibit anti-obesity properties, and their underlying mechanism has been widely reported. In this study, we demonstrated the metabolic benefits of Lactobacillus plantarum CCFM1180 in suppressing appetite, controlling body weight, correcting obesity-induced abnormalities, enhancing liver lipid metabolism, and protecting liver function in estrogen-deficient rats. The mechanisms associated with the anti-obesity and anti-dyslipidemia effects of CCFM1180 on estrogen-deficient rats were clarified. The results showed that CCFM1180 dramatically reduced food intake by activating the expression of estrogen receptor alpha (ERα) and increasing the level of leptin in abdominal adipose tissue. These changes, combined with the increased butyrate concentration and recovered bile acid structure, helped enhance lipid metabolism. Additionally, CCFM1180 treatment was found to be safer than exogenous estrogen supplementation. Thus, L. plantarum CCFM1180 could be considered a new therapeutic strategy for preventing and alleviating menopausal lipid abnormalities.

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Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum CCFM1180 attenuates obesity induced by estrogen deficiency by activating estrogen receptor alpha in abdominal adipose tissue and regulating gut microbiota-derived metabolites

Chen¹,

Mei²,

Guo³

et al. 2024

Food Science and Human Wellness

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“…Studies report that some metabolites produced by L. reuteri can participate in the regulation of the pathways in lipid metabolism, including the AMPK signaling pathway. The short-chain fatty acids produced by L. reuteri may reduce backfat thickness of Meishan piglets by regulating lipid metabolism [ 50 , 51 , 52 ]. Collectively, feeding L. reuteri to piglets could alter the metabolism process and improve feed utilization.…”

Section: Discussionmentioning

confidence: 99%

Exploring a Possible Link between the Fecal Microbiota and the Production Performance of Pigs

Cao

Wang

et al. 2022

Veterinary Sciences

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The backfat thickness of pigs not only affects the physical properties and taste of meat, but it also closely relates to the reproduction performance of sows. Accumulating evidence indicates that, apart from genetic factors, gut microbiota can also modulate the fat deposition and muscle growth. However, the differential microbiota in pigs with different backfat thickness, and whether microbiota affects backfat thickness, remains elusive. Firstly, 16S ribosomal RNA (16S rRNA) gene sequencing was performed on 62 fecal samples from pigs with different backfat thicknesses, and the compositions of microbiota among different groups with different backfat thicknesses were different. The abundance of Lactobacillus. reuteri (L. reuteri) and Prevotella sp RS2 was significantly higher in pigs with low-backfat thickness than that in pigs with middle and high-backfat thickness; meanwhile, the abundance of Desulfovibrio piger was significantly lower (p < 0.05) in pigs with low-backfat thickness. Furthermore, the functional profiling of microbial communities suggested that the abundance of isoquinoline alkaloid biosynthesis and styrene degradation were significantly lower (p < 0.05) in the low-backfat thickness group than that in middle and high-backfat thickness groups. Finally, L. reuteri fed to Meishan piglets was capable of improving the production performance and had the potential to reduce backfat thickness. This study provides new evidence that microbiota can regulate the phenotype of the host, and dietary supplementation with L. reuteri can improve the production performance of piglets.

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“…Interestingly, La − disposal, production, and transportation are not only regulated by extrinsic factors such as exercise dose and energy intake (i.e., distal physiology) but also by intrinsic factors like genetic variations in La − -related genes (MCTs) and the microbiota status [ 52 , 53 ]. In recent years, this direct interaction between La − levels and the microbiota status has been reported in different phenotypes, including the obese population and highly trained athletes [ 54 , 55 , 56 ]. Veillonella atypica , Eubacterium hallii group , Anaerobutyricum hallii , Anaerostipes , and many other bacterial species can metabolize La − to produce SCFAs and other intermediates that contribute to the microbial diversity and to the enrichment of specific bacterial populations after an exercise period [ 45 ].…”

Section: Physical Exercise–gut Health Relationshipmentioning

confidence: 99%

Examining the Interaction between Exercise, Gut Microbiota, and Neurodegeneration: Future Research Directions

et al. 2023

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Physical activity has been demonstrated to have a significant impact on gut microbial diversity and function. Emerging research has revealed certain aspects of the complex interactions between the gut, exercise, microbiota, and neurodegenerative diseases, suggesting that changes in gut microbial diversity and metabolic function may have an impact on the onset and progression of neurological conditions. This study aimed to review the current literature from several databases until 1 June 2023 (PubMed/MEDLINE, Web of Science, and Google Scholar) on the interplay between the gut, physical exercise, microbiota, and neurodegeneration. We summarized the roles of exercise and gut microbiota on neurodegeneration and identified the ways in which these are all connected. The gut–brain axis is a complex and multifaceted network that has gained considerable attention in recent years. Research indicates that gut microbiota plays vital roles in metabolic shifts during physiological or pathophysiological conditions in neurodegenerative diseases; therefore, they are closely related to maintaining overall health and well-being. Similarly, exercise has shown positive effects on brain health and cognitive function, which may reduce/delay the onset of severe neurological disorders. Exercise has been associated with various neurochemical changes, including alterations in cortisol levels, increased production of endorphins, endocannabinoids like anandamide, as well as higher levels of serotonin and dopamine. These changes have been linked to mood improvements, enhanced sleep quality, better motor control, and cognitive enhancements resulting from exercise-induced effects. However, further clinical research is necessary to evaluate changes in bacteria taxa along with age- and sex-based differences.

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Advances in the role and mechanism of lactic acid bacteria in treating obesity

Cited by 20 publications

References 80 publications

Lactobacillus plantarum CCFM1180 attenuates obesity induced by estrogen deficiency by activating estrogen receptor alpha in abdominal adipose tissue and regulating gut microbiota-derived metabolites

Lactobacillus plantarum CCFM1180 attenuates obesity induced by estrogen deficiency by activating estrogen receptor alpha in abdominal adipose tissue and regulating gut microbiota-derived metabolites

Exploring a Possible Link between the Fecal Microbiota and the Production Performance of Pigs

Examining the Interaction between Exercise, Gut Microbiota, and Neurodegeneration: Future Research Directions

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