Advances in the research on myokine-driven regulation of bone metabolism

Shao, MingHong; Wang, QiYang; Lv, QiuNan; Zhang, YuQiong; Gao, GuoXi; Lu, Sheng

doi:10.1016/j.heliyon.2023.e22547

Cited by 3 publications

(2 citation statements)

References 97 publications

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“…In addition, the content of glutamic acid enhancing the umami flavor of food was 541.4 ± 10.6 mg/100 g, the second highest among free amino acids in CPE [43]. β-amino isobutyric acid (BAIBA), which is beneficial for muscle mass development and protein synthesis, was not detected in CP, but had the highest content among free amino acids in CPE at 650.8 ± 23.6 mg/100 g [44]. The content of γ-amino-n-butyric acid (GABA), which improves cerebral blood flow, neuronal relaxation, and memory, was also higher in CPE (117.2 ± 5.5 mg/100 g) than that of CP (9.9 ± 0.3 mg/100 g) [45].…”

Section: Amino Acids Analysis Of Cpementioning

confidence: 99%

Optimization of Protease Treatment Conditions for Chlorella pyrenoidosa Protein Extraction and Investigation of Its Potential as an Alternative Protein Source

Cho,

Kim,

Jeong

et al. 2024

Foods

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This study aimed to determine enzymes that effectively extract Chlorella pyrenoidosa proteins and optimize the processing conditions using response surface methods. Furthermore, the potential of enzymatically hydrolyzed C. pyrenoidosa protein extract (CPE) as a substitute protein source was investigated. The enzymatic hydrolysis conditions for protein extraction were optimized using single-factor analysis and a response surface methodology–Box–Behnken design. The R2 value of the optimized model was 0.9270, indicating the reliability of the model, and the optimal conditions were as follows: a hydrolysis temperature of 45.56 °C, pH 9.1, and a hydrolysis time of 49.85 min. The amino acid composition of CPE was compared to that of C. pyrenoidosa powder (CP), which was found to have a higher content of essential amino acids (EAA). The electrophoretic profiles of CP and CPE confirmed that CPE has a low molecular weight. Furthermore, CPE showed higher antioxidant activity and phenol content than CP, with ABTS and DPPH radical scavenging abilities of 69.40 ± 1.61% and 19.27 ± 3.16%, respectively. CPE had high EAA content, antioxidant activity, and phenol content, indicating its potential as an alternative protein source. Overall, in this study, we developed an innovative, ecofriendly, and gentle enzymatic hydrolysis strategy for the extraction and refinement of Chlorella proteins.

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Section: Amino Acids Analysis Of Cpementioning

confidence: 99%

Optimization of Protease Treatment Conditions for Chlorella pyrenoidosa Protein Extraction and Investigation of Its Potential as an Alternative Protein Source

Cho,

Kim,

Jeong

et al. 2024

Foods

View full text Add to dashboard Cite

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“… 182 In addition, STAT3 signaling also promotes bone formation through direct signaling in osteocytes, mainly by stimulating the expression of transcription factors (e.g., C/EBPδ and C/EBPβ) to induce osteoblast differentiation. 183 In conclusion, normal bone remodeling and bone homeostasis depend on the JAK1/STAT3/suppressor of cytokine signaling 3 (SOCS3) signaling pathway. 180 Moreover, the JAK2/STAT5B pathway is also fundamental for osteoblast formation, 184 as it acts on important transcription factors, such as T box transcription factor 3, RUNX2, and BMP‐7, 185 which further illustrates the role of JAKs and STATs in bone conversion under inflammatory conditions.…”

Section: Signaling Pathways and Molecules In Bone Homeostasismentioning

confidence: 99%

Regulation of bone homeostasis: signaling pathways and therapeutic targets

Wu,

Li,

Jiang

et al. 2024

MedComm

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As a highly dynamic tissue, bone is continuously rebuilt throughout life. Both bone formation by osteoblasts and bone resorption by osteoclasts constitute bone reconstruction homeostasis. The equilibrium of bone homeostasis is governed by many complicated signaling pathways that weave together to form an intricate network. These pathways coordinate the meticulous processes of bone formation and resorption, ensuring the structural integrity and dynamic vitality of the skeletal system. Dysregulation of the bone homeostatic regulatory signaling network contributes to the development and progression of many skeletal diseases. Significantly, imbalanced bone homeostasis further disrupts the signaling network and triggers a cascade reaction that exacerbates disease progression and engenders a deleterious cycle. Here, we summarize the influence of signaling pathways on bone homeostasis, elucidating the interplay and crosstalk among them. Additionally, we review the mechanisms underpinning bone homeostatic imbalances across diverse disease landscapes, highlighting current and prospective therapeutic targets and clinical drugs. We hope that this review will contribute to a holistic understanding of the signaling pathways and molecular mechanisms sustaining bone homeostasis, which are promising to contribute to further research on bone homeostasis and shed light on the development of targeted drugs.

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Rest Pauses Between Strength Training Series and Changes In Bone Density in Athletes – A Pilot Study

Caha,

Babula,

Cacek

et al. 2024

StS

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A bone mineral density (BMD) test can provide a snapshot of bone health. The test identifies osteoporosis, determines the risk of fracture (broken bones), and measures the response to osteoporosis treatment. The study attempted to determine the effects of three different rest periods (30, 60, 120 sec.) as a variable factor in strength training on selected indicators of total bone density. The experiment involved four groups of five participants: three experimental groups and one control group. The study’s participants were characterized as athletic in ability, with strength sufficient training experience of more than 3 years and technical knowledge; the participants were male, aged 18-35 years (n = 20). To evaluate the effect of rest pauses in strength training on bone density, the states before and after the experiment were compared in individuals, the experimental groups and the control group. For analysis we use the BMD index (g /cm2), T-score, and Z-score. In the group which applied the 30-second rest period, the mean BMD increase was 0.0046 g/cm2 with a standard deviation of 0.0079 g/cm2, in the 60-second group it was -0.0260 g/cm2 with a standard deviation of 0.0412 g/cm2, and in the 120-second group it was 0.0082 g/cm2 with a standard deviation of 0.0168 g/cm2. At a statistical significance level of 5%, no significant difference in bone density was found between the groups for different rest pauses, but the factual significance of the relationship of strength training as a possible prevention of osteoporosis and solving problems of the musculoskeletal system.

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Advances in the research on myokine-driven regulation of bone metabolism

Cited by 3 publications

References 97 publications

Optimization of Protease Treatment Conditions for Chlorella pyrenoidosa Protein Extraction and Investigation of Its Potential as an Alternative Protein Source

Optimization of Protease Treatment Conditions for Chlorella pyrenoidosa Protein Extraction and Investigation of Its Potential as an Alternative Protein Source

Regulation of bone homeostasis: signaling pathways and therapeutic targets

Rest Pauses Between Strength Training Series and Changes In Bone Density in Athletes – A Pilot Study

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