Advances in the production of bioactive substances from marine unicellular microalgae Porphyridium spp.

Li, Shaohua; Ji, Liang; Shi, Qianwen; Wu, Haizhen; Fan, Jianhua

doi:10.1016/j.biortech.2019.122048

Cited by 70 publications

(40 citation statements)

References 122 publications

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“…Among these microalgae, red microalgae, especially the genus Porphyridium and Rhodella, have attracted interest for their richness in sulfated exopolysaccharides (EPS). The molar masses of EPS in these genera is in a range of 2-7 × 10 6 Da [3]. These anionic sulfated PS contain glucuronic acid and several major neutral sugars such as xylose, galactose and glucose [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Potential of Exopolysaccharide from Porphyridium marinum to Contend with Bacterial Proliferation, Biofilm Formation, and Breast Cancer

et al. 2021

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Exopolysaccharide (EPS) from marine microalgae are promising sources of a new generation of drugs. However, lot of them remain to be discovered and tested. In this study, EPS produced by Porphyridium marinum and its oligomers prepared by High Pressure Homogenizer have been tested for different biological activities, i.e., antibacterial, anti-fungal and antibiofilm activities on Candida albicans, as well as for their effects on the viability of murine breast cancer cells. Results have shown that all EPS samples present some biological activity. For antibacterial and antibiofilm activities, the native EPS exhibited a better efficiency with Minimum Inhibitory Concentration (MIC) from 62.5 µg/mL to 1000 µg/mL depending on the bacterial strain. For Candida albicans, the biofilm formation was reduced by about 90% by using only a 31.3 µg/mL concentration. Concerning breast cancer cells, lower molar masses fractions appeared to be more efficient, with a reduction of viability of up to 55%. Finally, analyses of polymers composition and viscosity measurements were conducted on all samples, in order to propose hypotheses involving the activities caused by the intrinsic properties of polymers.

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Section: Introductionmentioning

confidence: 99%

“…The molar masses of EPS in these genera is in a range of 2-7 × 10 6 Da [3]. These anionic sulfated PS contain glucuronic acid and several major neutral sugars such as xylose, galactose and glucose [3,4]. Nevertheless, the structures of these exopolymers have not yet been elucidated except for some oligosaccharidic sequences [5].…”

Section: Introductionmentioning

confidence: 99%

Potential of Exopolysaccharide from Porphyridium marinum to Contend with Bacterial Proliferation, Biofilm Formation, and Breast Cancer

et al. 2021

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“…Alternatively, the naturally harvested biomass is directly used or molecules of interest are synthesized. When the organisms that naturally produce the compounds of interest are used (Figure 3, left), the desired properties for scaledup products are a short production cycle and a high yield per unit (Li S. et al, 2019). One of the possible approaches for product harvesting is to trap the secondary metabolites secreted by the invertebrate or associated microorganisms to the surrounding water.…”

Section: Production Upscalingmentioning

confidence: 99%

The Essentials of Marine Biotechnology

Rotter

Barbier²,

Bertoni

et al. 2021

Front. Mar. Sci.

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Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well as tried to support new economic endeavors (ocean energy, desalination for water supply, and seabed mining). Modern societies and lifestyle resulted in an increased demand for dietary diversity, better health and well-being, new biomedicines, natural cosmeceuticals, environmental conservation, and sustainable energy sources. These societal needs stimulated the interest of researchers on the diverse and underexplored marine environments as promising and sustainable sources of biomolecules and biomass, and they are addressed by the emerging field of marine (blue) biotechnology. Blue biotechnology provides opportunities for a wide range of initiatives of commercial interest for the pharmaceutical, biomedical, cosmetic, nutraceutical, food, feed, agricultural, and related industries. This article synthesizes the essence, opportunities, responsibilities, and challenges encountered in marine biotechnology and outlines the attainment and valorization of directly derived or bio-inspired products from marine organisms. First, the concept of bioeconomy is introduced. Then, the diversity of marine bioresources including an overview of the most prominent marine organisms and their potential for biotechnological uses are described. This is followed by introducing methodologies for exploration of these resources and the main use case scenarios in energy, food and feed, agronomy, bioremediation and climate change, cosmeceuticals, bio-inspired materials, healthcare, and well-being sectors. The key aspects in the fields of legislation and funding are provided, with the emphasis on the importance of communication and stakeholder engagement at all levels of biotechnology development. Finally, vital overarching concepts, such as the quadruple helix and Responsible Research and Innovation principle are highlighted as important to follow within the marine biotechnology field. The authors of this review are collaborating under the European Commission-funded Cooperation in Science and Technology (COST) Action Ocean4Biotech – European transdisciplinary networking platform for marine biotechnology and focus the study on the European state of affairs.

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“…In recent decades, a large number of highly effective and low-toxicity marine active substances have been discovered in the vast ocean [18]. Among them, seaweed, as one of the important plants in the marine, has a variety of active components and has been widely studied [19,20]. The active ingredients of seaweed include Sulfated seaweed polysaccharides [21], polyphenols [22], proteins [23], terpenes [24], alkaloids [25], phenolic compounds [26], and halogenated compounds [27].…”

Section: Introductionmentioning

confidence: 99%

The Inhibition Effect of the Seaweed Polyphenol, 7-Phloro-Eckol from Ecklonia Cava on Alcohol-Induced Oxidative Stress in HepG2/CYP2E1 Cells

et al. 2021

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The liver is vulnerable to oxidative stress-induced damage, which leads to many diseases, including alcoholic liver disease (ALD). Liver disease endanger people’s health, and the incidence of ALD is increasing; therefore, prevention is very important. 7-phloro-eckol (7PE) is a seaweed polyphenol, which was isolated from Ecklonia cava in a previous study. In this study, the antioxidative stress effect of 7PE on HepG2/CYP2E1 cells was evaluated by alcohol-induced cytotoxicity, DNA damage, and expression of related inflammation and apoptosis proteins. The results showed that 7PE caused alcohol-induced cytotoxicity to abate, reduced the amount of reactive oxygen species (ROS) and nitric oxide (NO), and effectively inhibited DNA damage in HepG2/CYP2E1 cells. Additionally, the expression levels of glutathione (GSH), superoxide dismutase (SOD), B cell lymphoma 2 (Bcl-2), and Akt increased, while γ-glutamyltransferase (GGT), Bcl-2 related x (Bax), cleaved caspase-3, cleaved caspase-9, nuclear factor-κB (NF-κB), and JNK decreased. Finally, molecular docking proved that 7PE could bind to BCL-2 and GSH protein. These results indicate that 7PE can alleviate the alcohol-induced oxidative stress injury of HepG2 cells and that 7PE may have a potential application prospect in the future development of antioxidants.

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Advances in the production of bioactive substances from marine unicellular microalgae Porphyridium spp.

Cited by 70 publications

References 122 publications

Potential of Exopolysaccharide from Porphyridium marinum to Contend with Bacterial Proliferation, Biofilm Formation, and Breast Cancer

Potential of Exopolysaccharide from Porphyridium marinum to Contend with Bacterial Proliferation, Biofilm Formation, and Breast Cancer

The Essentials of Marine Biotechnology

The Inhibition Effect of the Seaweed Polyphenol, 7-Phloro-Eckol from Ecklonia Cava on Alcohol-Induced Oxidative Stress in HepG2/CYP2E1 Cells

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