Advances in the pathogenesis of FLT3-mutated acute myeloid leukemia and targeted treatments
Serena Travaglini,
Carmelo Gurnari,
Tiziana Ottone
et al.
Abstract:Purpose of review
FLT3 mutations are among the most common myeloid drivers identified in adult acute myeloid leukemia (AML). Their identification is crucial for the precise risk assessment because of the strong prognostic significance of the most recurrent type of FLT3 alterations, namely internal tandem duplications (ITDs). Recent advances in the pathogenesis and biology of FLT3-mutated AML have opened an opportunity for development and application of selective in… Show more
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