Advances in the medical management of skin and soft tissue infections

Abstract

Skin and soft tissue infections are some of the most common infectious disease diagnoses in both inpatient and outpatient settings. With bacterial resistance to antimicrobials growing, decision making on empiric antibiotics is becoming increasingly difficult. Additionally, the most recent guidance from a professional society on the treatment of skin and soft tissue infections was published in 2014 by the Infectious Diseases Society of America and is now two years old. New antimicrobial agents have been developed and approved for the treatment of skin and soft tissue infections since then, and more are in the pipeline. This review summarizes the evidence on treatments that are new or in development and the potential repurposing of old antimicrobials. The clinical utility of these treatments is also discussed.

Subscapular Abscess Caused by Panton-Valentine Leukocidin-PositiveStaphylococcus aureus: An Atypical Presentation

“…In this case, antibiotic treatment was also indicated due to the raised CRP [ 16 ]. To enable rationalisation of antibiotics and prevent spread of resistant strains, samples of fluid obtained when performing drainage should be sent off for culture and microscopy as standard practice [ 17 ]. Empirical antibiotic therapy for mild forms of skin and soft tissue infections includes flucloxacillin and clindamycin as the antibiotics of choice.…”

New Antibiotics in the Therapy of Osteomyelitis

“…This defensin-mimetic non-peptidic molecule has bactericidal efficacy for Gram-positive and Gram-negative bacteria, even in non-replicative state [84] . Phase 2-studies have been completed and phase 3 studies are underway for acute bacterial skin and skin structure infections [85] .…”

A Reversible Adhesive Hydrogel Tape

“…There also remains a need for reversible hydrogel coatings, termed temporary hydrogel coatings, which are expected to be completely cleared after uses, particularly as one-off medical supplies on human bodies to prevent crossing infection. [26,27] For these cases, a trade-off exists between the strengthened attachment and traceless detachment of hydrogel coatings on solid substrates.…”