Advances in the Management of Peripheral Artery Disease

Barshes, Neal R.; Grant, Courtney L

doi:10.1007/s11892-019-1155-0

Cited by 7 publications

(3 citation statements)

References 54 publications

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“…This could be explained by the progressive nature of atherosclerosis. Hence, first and foremost is to maximize the benefits of exercise and medical therapy, including the management of cardiovascular risk factors [6,10,11] (Fig. 1).…”

Section: Importance Of Medical Therapymentioning

confidence: 99%

Review new concepts in pharmacotherapy for peripheral arterial disease

Kotalczyk

Vallabhaneni

Lip

2021

Current Opinion in Cardiology

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Purpose of reviewTo provide an overview of new concepts in the pharmacotherapy of patients with peripheral artery disease (PAD).Recent findingsModern therapeutic strategies for patients with PAD include specific symptom management and multidisciplinary prevention of cardiovascular events. Low-dose rivaroxaban in combination with aspirin improves outcomes compared with aspirin monotherapy among patients with PAD. Other novel concepts include the use of bosentan, vorapaxar or sildenafil among symptomatic patients with PAD. Likewise, lipid-lowering therapy reduces the risk of major cardiovascular and limb events.SummaryPersonalized management, identification of risk factors and shared-decision making are crucial in improving the best medical therapy for patients with PAD. Further studies are needed to assess the long-term safety and efficacy of novel strategies in real-world patients.

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Section: Importance Of Medical Therapymentioning

confidence: 99%

Review new concepts in pharmacotherapy for peripheral arterial disease

Kotalczyk

Vallabhaneni

Lip

2021

Current Opinion in Cardiology

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“…Lama menderita DM tipe dua meningkatkan penumpukan glukosa pada darah yang menyebabkan kerusakan pada pembuluh darah, sehingga menimbulkan risiko terjadinya komlikasi yang umumnya akan ada pada 5-10 tahun. Ada hubungan antara lama menderita DM dengan gangguan peredaran darah pada jaringan perifer (Hicks & Selvin, 2019) dan kejadian ini sedikit banyak dapat mempengaruhi kualitas hidup penderita DM (Barshes & Grant, 2019;Santosa & Listiono, 2017). Sebagai bentuk pencegahan, menjaga asupan makanan (Irma, 2019) dan melakukan olah raga (Rahayu et al, 2017).…”

Section: Pembahasanunclassified

Deteksi Dini Peripheral Artery Disease melalui Pemeriksaan Ankle Brachial Index pada Kelompok Prolanis di Puskesmas Poasia

Said¹,

Novianti²,

Fety³

2021

Health Inf J Penelit

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Peripheral Artery Disease (PAD) merupakan komplikasi Diabetes Melitus (DM) Perubahan pada dinding pembuluh darah menyebabkan penurunan aliran darah (perfusi) ke ekstremitas bawah yang ditandai dengan penurunan ankle brachial index (ABI). Adapun tujuan penelitian ini adalah Mendapatkan gambaran Nilai ABI pada pasien diabetes di kelompok prolanis Di Puskesmmas Poasia Kota Kendari Sulawesi Tenggara. Penelitian ini merupakan penelitian deskriptif, mendapatkan gambaran nilai ABI pada pasien dengan DM yang terdaftar sebagai pasien prolanis di puskemas poasia kendari sebanyak 14 orang. Hasil penelitian diperoleh yaitu: rata-rata berjenis kelamin adalah perempuan sebanyak 11 responden, rata-rata usia responden 46-55 tahun sebanyak 6 responden responden, dan rata-rata lama menderita responden adalah 0-2 tahun sebanyak 9 responden. Hasil penelitian yang diperoleh nilai ABI pada 14 pasien Diabetes Melitus tipe II (DM tipe II) masih banyak yang masuk dalam kategori normal yaitu sebanyak 9 responden (64,3%) dan terdapat (35,7%) responden memiliki ABI abnormal yaitu berada di kategori oklusi singan dan sedang. ABI normal pada responden dipengaruhi oleh rata-rata lama sakit DM hanya kurun waktu 5 tahun, hal tersebut yang menyebabkan nilai ABI dalam rentang normal dan belum banyak yang mengalami gangguan.

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“…These foot ulcers, secondary to PAD affecting tibial and peroneal arteries, are found in about 50% of cases. The management approach for foot ulcers in patient with diabetes and PAD is to relieve ischemic pain, heal the ulcers and to prevent amputation [22,23]. CO 2 is known to causes vasodilation and therefore bathing limbs in CO 2 -enriched water will increase blood flow in the skin, given that CO 2 can permeate through the skin [20].…”

Section: Introductionmentioning

confidence: 99%

A Novel Bathing Therapeutic Approach for Diabetic Foot Ulcers

et al. 2021

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Ineffective healing and treatment of foot ulcers can lead to an infection and gangrene of the wound area that ultimately results in the loss of the limb. The incidence of foot ulcers is higher in patients with diabetes, peripheral vascular disease and kidney disease. Accordingly, this study was undertaken to assess the ability of foot bathing in CO2-enriched water to heal foot ulcers. The design was a double-blinded, randomized, placebo-controlled study. Patients with at least one foot ulcer were randomized to receive either a treatment with bath therapy at 37 ± 0.5 °C containing either 1000–1200 ppm CO2-enriched tap water (the intervention) or non-carbonated tap water at 37 ± 0.5 °C (the control group). Treatment was conducted three times/week for 15 min per session for up to 16 weeks for a total of 48 treatment sessions. Before and at the end of every treatment month, wound size, wound area oxygenation and the ankle brachial index were measured. In addition, the McGill pain questionnaire was conducted. Blood was also collected at these time points (for a total of five collections) for the measurement of different biomarkers. While no significant differences (p < 0.05) in the group/time interaction effect were observed, a clear separation within the wound area reduction/wound area/oxygenated Hb outcomes was seen between placebo (control) and treatment (CO2) group. This pilot study is suggestive that bathing in CO2-enriched water may accelerate the healing of foot ulcers.

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Advances in the Management of Peripheral Artery Disease

Cited by 7 publications

References 54 publications

Review new concepts in pharmacotherapy for peripheral arterial disease

Review new concepts in pharmacotherapy for peripheral arterial disease

Deteksi Dini Peripheral Artery Disease melalui Pemeriksaan Ankle Brachial Index pada Kelompok Prolanis di Puskesmas Poasia

A Novel Bathing Therapeutic Approach for Diabetic Foot Ulcers

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