Advances in the genomics of ticks and tick-borne pathogens

Jongejan, Frans; Nene, Vishvanath; Fuente, José de la; Pain, Arnab; Willadsen, Peter

doi:10.1016/j.pt.2007.07.004

Cited by 27 publications

(17 citation statements)

References 44 publications

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“…They are important players in the vector-host-pathogen triangle in which all members interact and affect each other's success (Jongejan et al, 2007). An important question in vector studies is whether the genetic structure of the arthropod can inform patterns of disease transmission.…”

Section: Discussionmentioning

confidence: 99%

“…As obligate parasites and vectors, ticks have a direct influence on their hosts and the pathogens they transmit (Anderson and Magnarelli, 2008;Hill and Wikel, 2005;Pagel Van Zee et al, 2007;Sonenshine, 1993). Each member of a host-vector-pathogen system is affected by the other players; this combined effect can influence genetic variation in ticks (Jongejan et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Thirty years of tick population genetics: A comprehensive review

Araya-Anchetta

Busch

Scoles

et al. 2015

Infection, Genetics and Evolution

109

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Population genetic studies provide insights into the basic biology of arthropod disease vectors by estimating dispersal patterns and their potential to spread pathogens. In wingless vectors, such as ticks, gene flow will be defined in large part by the mobility of their hosts. However, tick behaviors and life cycle strategies can limit their dispersal even on highly mobile hosts and lead to an increase in genetic structure. In this review we synthesize the published literature from three decades of tick population genetic studies. Based on studies from 22 tick species (including representatives from Amblyomma, Bothriocroton, Dermacentor, Ixodes, Ornithodoros, and Rhipicephalus), observed levels of population genetic structure in ticks varied from no structure to very high levels. In about half of the species (including representatives from Amblyomma, Bothriocroton, Dermacentor, and Ornithodoros), tick genetic structure appeared to be determined primarily by the movement capacity of hosts, with low gene flow observed in ticks that use smaller bodied less mobile hosts and high gene flow in ticks using highly mobile hosts. In a number of other species (primarily from Ixodes, Ornithodoros, and Rhipicephalus), behavioral limitations to gene flow appeared to result in greater genetic structure than expected based upon host movement capability alone. We also discuss the strengths and limitations of genetic markers and their applicability to ticks and suggest possible analyses when planning population genetic studies for ticks.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thirty years of tick population genetics: A comprehensive review

Araya-Anchetta

Busch

Scoles

et al. 2015

Infection, Genetics and Evolution

109

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“…Now, the use of reverse genetic approaches and the feasibility of RNA interference (30) has markedly increased their potential as a valuable invertebrate model (31). We are unaware of another study in which RNA interference is used to reveal the functions of proteins involved in a complex metabolic pathway in ticks.…”

Section: Discussionmentioning

confidence: 99%

Knockdown of proteins involved in iron metabolism limits tick reproduction and development

Hajdušek

Sojka²,

Kopáček³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

149

129

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Ticks are among the most important vectors of a wide range of human and animal diseases. During blood feeding, ticks are exposed to an enormous amount of free iron that must be appropriately used and detoxified. However, the mechanism of iron metabolism in ticks is poorly understood. Here, we show that ticks possess a complex system that efficiently utilizes, stores and transports non-heme iron within the tick body. We have characterized a new secreted ferritin (FER2) and an iron regulatory protein (IRP1) from the sheep tick, Ixodes ricinus, and have demonstrated their relationship to a previously described tick intracellular ferritin (FER1). By using RNA interference-mediated gene silencing in the tick, we show that synthesis of FER1, but not of FER2, is subject to IRP1-mediated translational control. Further, we find that depletion of FER2 from the tick plasma leads to a loss of FER1 expression in the salivary glands and ovaries that normally follows blood ingestion. We therefore suggest that secreted FER2 functions as the primary transporter of non-heme iron between the tick gut and the peripheral tissues. Silencing of the fer1, fer2, and irp1 genes by RNAi has an adverse impact on hatching rate and decreases postbloodmeal weight in tick females. Importantly, knockdown of fer2 dramatically impairs the ability of ticks to feed, thus making FER2 a promising candidate for development of an efficient anti-tick vaccine.cytosolic aconitase ͉ IRP ͉ ferritin ͉ RNAi

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“…appendiculatus , Rh. microplus , A. variegatum , I. scapularis , I. ricinus , I. pacificus , and Hyalomma anatolicum [34]. Some of these tick genes have been used to create a repository of clustered and auto-annotated data in the form of species-specific gene indices.…”

Section: Methods Of Research Into Tick-rickettsiae Interactionsmentioning

confidence: 99%

The relationship between spotted fever groupRickettsiaeand Ixodid ticks

et al. 2009

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Spotted fever group Rickettsiae are predominantly transmitted by ticks. Rickettsiae have developed many strategies to adapt to different environmental conditions, including those within their arthropod vectors and vertebrate hosts. The tick-Rickettsiae relationship has been a point of interest for many researchers, with most studies concentrating on the role of ticks as vectors. Unfortunately, less attention has been directed towards the relationship of Rickettsiae with tick cells, tissues, and organs. This review summarizes our current understanding of the mechanisms involved in the relationship between ticks and Rickettsiae and provides an update on the recent methodological improvements that have allowed for comprehensive studies at the molecular level.

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Advances in the genomics of ticks and tick-borne pathogens

Cited by 27 publications

References 44 publications

Thirty years of tick population genetics: A comprehensive review

Thirty years of tick population genetics: A comprehensive review

Knockdown of proteins involved in iron metabolism limits tick reproduction and development

The relationship between spotted fever groupRickettsiaeand Ixodid ticks

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