Advances in the Genomics and Proteomics of the Freshwater Intermediate Snail Host of Schistosoma mansoni, Biomphalaria glabrata

Ittiprasert, Wannaporn; Myers, Jocelyn; Odoemelam, Edwin C.; Raghavan, Nithyakalyani; Lewis, Fred A.; Bridger, Joanna M.; Knight, Matty

doi:10.1007/978-1-4419-7028-2_8

Cited by 3 publications

(2 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By using RAPD-PCR analysis, Gutierrez et al (2003) were able to differentiate genetically defined lines of Pseudosuccinea columella selected for susceptibility and resistance to F. hepatica. RAPDs genetic variation was also detected for B. glabrata (Adema et al, 2010;Ittiprasert et al, 2011) and B. tenagophila (Ittiprasert et al, 2011) susceptible and resistant laboratory selected snails.…”

Section: Discussionmentioning

confidence: 89%

Immunological and Molecular Detection of Digenetic Infections in Different Species of Egyptian Freshwater Snails

Saad

Varjabedian

Abdel‐Gaber

et al. 2013

Journal of the Egyptian Society of Parasitology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 89%

Immunological and Molecular Detection of Digenetic Infections in Different Species of Egyptian Freshwater Snails

Saad

Varjabedian

Abdel‐Gaber

et al. 2013

Journal of the Egyptian Society of Parasitology

View full text Add to dashboard Cite

“…Thus far, work has been done most extensively using the Biomphalaria - Schistosoma model, and has led to the nomenclature of some stocks known for resistance (e.g., pigmented BS-90 [ 48 ], black-eye 10-R2 [ 49 ], and 13-16-IR [ 50 ]) or susceptibility (e.g., the albino M-line and NMRI [ 51 ], and BB02 [ 52 ]) to S. mansoni infection, which are now maintained in the laboratory for research purposes. In contrast to the 10-R2 and 13-16-IR strains, however, BS-90 demonstrates unflinching resistance stability, irrespective of age (juvenile or adult), under laboratory conditions [ 40 , 53 ].…”

Section: Biology Of Snail Resistance/susceptibility To Smentioning

confidence: 99%

Treading the Path towards Genetic Control of Snail Resistance to Schistosome Infection

Famakinde¹

2018

TropicalMed

View full text Add to dashboard Cite

Schistosomiasis remains the most important tropical snail-borne trematodiasis that threatens many millions of human lives. In achieving schistosomiasis elimination targets, sustainable control of the snail vectors represents a logical approach. Nonetheless, the ineffectiveness of the present snail control interventions emphasizes the need to develop new complementary strategies to ensure more effective control outcomes. Accordingly, the use of genetic techniques aimed at driving resistance traits into natural vector populations has been put forward as a promising tool for integrated snail control. Leveraging the Biomphalaria-Schistosoma model system, studies unraveling the complexities of the vector biology and those exploring the molecular basis of snail resistance to schistosome infection have been expanding in various breadths, generating many significant discoveries, and raising the hope for future breakthroughs. This review provides a compendium of relevant findings, and without neglecting the current existing gaps and potential future challenges, discusses how a transgenic snail approach may be adapted and harnessed to control human schistosomiasis.

show abstract

Analysis of rhodopsin G protein-coupled receptor orthologs reveals semiochemical peptides for parasite (Schistosoma mansoni) and host (Biomphalaria glabrata) interplay

Phan

Liang

Zhao

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Schistosomiasis is a medically significant disease caused by helminth parasites of the genus Schistosoma. The schistosome life cycle requires chemically mediated interactions with an intermediate (aquatic snail) and definitive (human) host. Blocking parasite development within the snail stage requires improved understanding of the interactions between the snail host and the Schistosoma water-borne free-living form (miracidium). Innovations in snail genomics and aquatic chemical communication provide an ideal opportunity to explore snail-parasite coevolution at the molecular level. Rhodopsin G protein-coupled receptors (GPCRs) are of particular interest in studying how trematode parasites navigate towards their snail hosts. The potential role of GPCRs in parasites makes them candidate targets for new antihelminthics that disrupt the intermediate host life-cycle stages, thus preventing subsequent human infections. A genomic-bioinformatic approach was used to identify GPCR orthologs between the snail Biomphalaria glabrata and miracidia of its obligate parasite Schistosoma mansoni. We show that 8 S. mansoni rhodopsin GPCRs expressed within the miracidial stage share overall amino acid similarity with 8 different B. glabrata rhodopsin GPCRs, particularly within transmembrane domains, suggesting conserved structural features. These GPCRs include an orphan peptide receptor as well as several with strong sequence homologies with rhabdomeric opsin receptors, a serotonin receptor, a sulfakinin (SK) receptor, an allatostatin-A (buccalin) receptor and an FMRFamide receptor. Buccalin and FMRFa peptides were identified in water conditioned by B. glabrata, and we show synthetic buccalin and FMRFa can stimulate significant rates of change of direction and turn-back responses in S. mansoni miracidia. Ortholog GPCRs were identified in S. mansoni miracidia and B. glabrata. These GPCRs may detect similar ligands, including snail-derived odorants that could facilitate miracidial host finding. These results lay the foundation for future research elucidating the mechanisms by which GPCRs mediate host finding which can lead to the potential development of novel anti-schistosome interventions.

show abstract

Advances in the Genomics and Proteomics of the Freshwater Intermediate Snail Host of Schistosoma mansoni, Biomphalaria glabrata

Cited by 3 publications

References 80 publications

Immunological and Molecular Detection of Digenetic Infections in Different Species of Egyptian Freshwater Snails

Immunological and Molecular Detection of Digenetic Infections in Different Species of Egyptian Freshwater Snails

Treading the Path towards Genetic Control of Snail Resistance to Schistosome Infection

Analysis of rhodopsin G protein-coupled receptor orthologs reveals semiochemical peptides for parasite (Schistosoma mansoni) and host (Biomphalaria glabrata) interplay

Contact Info

Product

Resources

About