Advances in the Diagnosis and Management of Chancroid

D'Costa, L J; Bowmer, Ian; Nsanze, H; Dylewski, Joe; Fransen, L; Fa, Plummer; Piot, Peter; Ar, Ronald

doi:10.1097/00007435-198607000-00019

Cited by 17 publications

(9 citation statements)

References 17 publications

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“…Low levels of esterases, which were active against P-naphthylamide derivatives of short-chain (<C8) fatty acids, were present in most strains (29,170). Esterases active against derivatives of fatty acids with a chain length of >C10 were either absent or detected in a minority of strains (29,170 40,000 (Fig. 3).…”

Section: Biochemical Characteristicsmentioning

confidence: 97%

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Chancroid and Haemophilus ducreyi

1989

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Haemophilus ducreyi is the causative agent of chancroid, one of the genital ulcerative diseases. H. ducreyi is the major cause of genital ulcer disease in Africa and Southeast Asia and is of increasing concern in the United States. Definitive diagnosis of chancroid requires the isolation and identification of H. ducreyi, but isolation of this organism is difficult and the available medium is not optimal for all strains. Fluorescent antibody and serologic tests are of limited value. In general, our knowledge of this organism is rather limited, and indeed, recent studies have questioned the placement of H. ducreyi in the genus Haemophilus. H. ducreyi has relatively few biochemical activities, and epidemiologic studies are limited because there are limited phenotypic markers available for strain typing. Specific virulence factors of H. ducreyi have yet to be identified. Antimicrobial resistance in H. ducreyi is of special concern, as this organism has acquired both gram-negative and gram-positive resistance determinants. In addition, some of these determinants can be mobilized and transferred to other Haemophilus species or to Neisseria gonorrhoeae.

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Section: Biochemical Characteristicsmentioning

confidence: 97%

“…Painful, tender inguinal lymphadenopathy is a characteristic feature and may be present in up to 50% of patients with chancroid (40,138,156). The lymphadenopathy is usually unilateral (121,138).…”

Section: Featuresmentioning

confidence: 99%

Chancroid and Haemophilus ducreyi

1989

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Section: Clinical Featuresmentioning

confidence: 99%

Chancroid and Haemophilus ducreyi.

Morse¹

1989

Clinical Microbiology Reviews

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The organism was observed both within and outside of neutrophils. It grew in chains, especially in tissue, but also appeared as single cells in secretions. Ducrey consistently observed this organism from a cleansed soft chancre, in pus from an unruptured bubo, and in the deep portion of an abscess. Since he was unable to culture the organism in vitro, he used serial cutaneous inoculations to establish the specificity of the infectious agent. His observations were confirmed by Krefting in 1892 and also by Unna in 1892 (as cited in reference 160). There is some controversy concerning the first culture isolation of Haemophilus ducreyi. Sullivan (160) attributed the first cultures of the bacillus of Ducrey to Lenglet in 1898 and Bezancon, Griffin, and LeSourd in 1900. However, Istamanoff (131) and Akspianz (38) have been credited with earlier isolations.

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“…The chancroid ulcer is painful while the ulcer of syphilis is not painful. Erythromycin and ceftriaxone are the currently preferred treatments (9,29).…”

Section: Dermatological Problems In the Athlete-sexualmentioning

confidence: 99%