Advances in the Clinical Application of Histamine and Diamine Oxidase (DAO) Activity: A Review

Abstract

The serum level of diamine oxidase (DAO) reflects the integrity and maturation of the small intestinal mucosa. This measure is important in diagnosing various diseases, including chronic urticaria tachyphylaxis, multiple organ dysfunction syndrome, preterm abortion, and migraine. This review aimed to summarize the findings of previous studies on the changes in DAO levels in diverse diseases and the application of this enzyme in the clinical setting, as well as the roles of this enzyme under physiological and pathological conditions. The advances in the mechanism and clinical application of DAO presented in this review will contribute to a better understanding of this enzyme and open up new and broader perspectives for future basic research and clinical applications.

Bifidobacterium animalis subsp. lactis boosts neonatal immunity: unravelling systemic defences against Salmonella

“…1D. Additionally, the serum level of DAO, a clinical indicator of intestinal mucosal function, 25 showed a significant elevation (Fig. 1D).…”

The Effect of Copper Nanoparticles and a Different Source of Dietary Fibre in the Diet on the Integrity of the Small Intestine in the Rat

“…When the intestinal mucosa is damaged, e.g., as a result of ischemia, hypoxia, contact with a harmful factor present in food or tissue nutrition disorders, an inflammatory reaction is triggered with the release of histamine. Due to the necessity of its deactivation, a decrease in the level of DAO in the intestinal mucosa is observed, resulting in a simultaneous decrease in the level of this indicator in the blood [ 47 ]. Our results indicate that the replacement of Cu in the standard form of CuCO 3 by an equivalent dose of CuNPs had no effect on the DAO level in the blood plasma and small intestine.…”