Advances in the Clinical Application of Histamine and Diamine Oxidase (DAO) Activity: A Review

Abstract

The serum level of diamine oxidase (DAO) reflects the integrity and maturation of the small intestinal mucosa. This measure is important in diagnosing various diseases, including chronic urticaria tachyphylaxis, multiple organ dysfunction syndrome, preterm abortion, and migraine. This review aimed to summarize the findings of previous studies on the changes in DAO levels in diverse diseases and the application of this enzyme in the clinical setting, as well as the roles of this enzyme under physiological and pathological conditions. The advances in the mechanism and clinical application of DAO presented in this review will contribute to a better understanding of this enzyme and open up new and broader perspectives for future basic research and clinical applications.

Bifidobacterium animalis subsp. lactis boosts neonatal immunity: unravelling systemic defences against Salmonella

“…1D. Additionally, the serum level of DAO, a clinical indicator of intestinal mucosal function, 25 showed a significant elevation (Fig. 1D).…”

The Effect of Copper Nanoparticles and a Different Source of Dietary Fibre in the Diet on the Integrity of the Small Intestine in the Rat

“…When the intestinal mucosa is damaged, e.g., as a result of ischemia, hypoxia, contact with a harmful factor present in food or tissue nutrition disorders, an inflammatory reaction is triggered with the release of histamine. Due to the necessity of its deactivation, a decrease in the level of DAO in the intestinal mucosa is observed, resulting in a simultaneous decrease in the level of this indicator in the blood [ 47 ]. Our results indicate that the replacement of Cu in the standard form of CuCO 3 by an equivalent dose of CuNPs had no effect on the DAO level in the blood plasma and small intestine.…”

Reduction of Stress and Jet Lag, Improvement of Well-Being, Sleep Quality and Body-Mind Regeneration by Vinci Power Nap® Neuroarchitecture System: Innovative Solution for Leaders, Employees, Travelers

“…Moreover, during swinging in VPN cocoon, apart from healing activation of vagus nerve [66,67], the body's active hydrodynamic fluctuations might affect the acceleration of enzymatic catalysis [74] because in the presence of the enzyme, the activation energy for the reaction is less than in its absence; it means that the enzymes can speed up the reaction [74]. For example, swinging in VPN synchronization system [120] for 20 min power nap accelerates enzymes (also as DAO and HMNT) [121], which neutralizes endogenous and exogenous histamine, which can help to prevent and reduce inflammations and its manifestations that are very similar to jet lag symptoms. What showed the pilot research on man 52 years that after 10 VPN sessions, conducted between June 5, 2023 and June 22, 2023, there was increase of enzyme DAO from 9,8 to 15,2 U/ml (the minimum level of norm is from 10 U/ml); also, the level of vitamin D3 increased from 28,7 to 32,4 ng/mL (the minimum level of norm is from 30 ng/mL) (Tables 1 and 2).…”

“…The author has hypothesized that neurotechnology of VPN sessions strengthened together with vitamins D3, B6, and C; zinc; enzyme DAO; and antihistamines for H1, H2, H3, and H4 applied before, during, and after the flight or space trip [39] can be a great prevention for pilots, astronauts, and passengers to overcome jet lag, tiredness, and stress, as well as can be helpful in rehabilitation and prevention from organs transplantation rejection [121]. The author has concluded that thanks to VPN system by its identifying the reset mechanism of the internal oscillators and the frequency of hydrodynamic, there is a possibility to balance the endocrine body's interaction on the external environmental factors.…”