Advances in the Chemistry of Amino and Nitro Compounds

Abstract

Introduction Amino Compounds Nitro Compounds

Reductive Elimination to Form C(sp3)–N Bonds from Palladium(II) Primary Alkyl Complexes

“…Reductive eliminations are fundamental reactions that constitute the bond-forming step of many catalytic processes . However, well-characterized complexes that undergo reductive elimination to form C­(sp 3 )–N bondsa prevalent moiety in all applications of chemistry − are rare. Most examples of this reaction occur through an S N 2-type attack of a nitrogen nucleophile on an alkyl ligand.…”

Palladium-Catalyzed Cross Coupling of Secondary and Tertiary Alkyl Bromides with a Nitrogen Nucleophile

“…N -Alkylation of nitrogen nucleophiles is traditionally achieved through substitution − or reductive amination. − Although substitutions of primary or benzylic alkyl electrophiles are facile, reactions with secondary electrophiles typically require elevated temperatures. Moreover, unactivated tertiary alkyl electrophiles often undergo elimination in preference to substitution, and tertiary alcohols are inherently unsuitable for reductive amination or borrowing hydrogen − strategies.…”