Advances in the biotechnological glycosylation of valuable flavonoids

Xiao, Jianbo; Muzashvili, T; Georgiev, Milen I.

doi:10.1016/j.biotechadv.2014.04.006

Cited by 275 publications

(206 citation statements)

References 158 publications

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“…Epidemiologic studies have suggested that a diet rich in flavones exhibits some anti-carcinogenic as well as anti-angiogenic and anti-inflammatory bioactivities [60–62]. Flavonoids also have antioxidant and anti-diabetic potential when added to food [63]. Furthermore, flavonoids also play an important role in protecting the plant itself against biotic and abiotic stresses [64].…”

Section: Discussionmentioning

confidence: 99%

Integrated genomics-based mapping reveals the genetics underlying maize flavonoid biosynthesis

et al. 2017

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BackgroundFlavonoids constitute a diverse class of secondary metabolites which exhibit potent bioactivities for human health and have been indicated to play an important role in plant development and defense. However, accumulation and variation of flavonoid content in diverse maize lines and the genes responsible for their biosynthesis in this important crop remain largely unknown. In this study, we combine genetic mapping, metabolite profiling and gene regulatory network analysis to further enhance understanding of the maize flavonoid pathway.ResultsWe repeatedly detected 25 QTL corresponding to 23 distinct flavonoids across different environments or populations. In addition, a total of 39 genes were revealed both by an expression based network analysis and genetic mapping. Finally, the function of three candidate genes, including two UDP-glycosyltransferases (UGT) and an oxygenase which belongs to the flavone synthase super family, was revealed via preliminary molecular functional characterization.ConclusionWe explored the genetic influences on the flavonoid biosynthesis based on integrating the genomic, transcriptomic and metabolomic information which provided a rich source of potential candidate genes. The integrated genomics based genetic mapping strategy is highly efficient for defining the complexity of functional genetic variants and their respective regulatory networks as well as in helping to select candidate genes and allelic variance before embarking on laborious transgenic validations.Electronic supplementary materialThe online version of this article (doi:10.1186/s12870-017-0972-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Integrated genomics-based mapping reveals the genetics underlying maize flavonoid biosynthesis

et al. 2017

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“…These activities can be attributed to bioactive compounds as flavonoids present in this plant. Flavonoids (C6-C3-C6) can be classified into different sub-classes (flavones, flavanones, flavonols, isoflavones, flavanols, chalcones and anthocyanins) and they are commonly found conjugated to sugars in the form of O-glycosides or C-glycosides forms [6].…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and biological activities of n-butanol extract of <i>Lepidium sativum L</i> (Brassicaceae) seed

Ait-yahia¹,

Perreau²,

Bouzroura³

et al. 2018

Trop. J. Pharm Res

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“…Usually, flavonoids in plants are combined with one or more sugar molecules and known as flavonoid glycosides [24]. Accumulating evidence suggests that flavonoids exhibit extensive pharmacological effects and biological effects in vitro and in vivo including antioxidant, 5 anti-inflammation, anti-microbial, anti-tumor, anti-asthma, anti-adipogenesis and anti-diarrhea [19,20,[23][24][25][26]. Because of the potential beneficial effects of flavonoids on human health, foods rich in flavonoids have attracted great interest recently [25,26].…”

Section: Introductionmentioning

confidence: 99%

“…Accumulating evidence suggests that flavonoids exhibit extensive pharmacological effects and biological effects in vitro and in vivo including antioxidant, 5 anti-inflammation, anti-microbial, anti-tumor, anti-asthma, anti-adipogenesis and anti-diarrhea [19,20,[23][24][25][26]. Because of the potential beneficial effects of flavonoids on human health, foods rich in flavonoids have attracted great interest recently [25,26]. It has been reported that the polyphenols of average human dietary intake is about 1g/day, with two-third being flavonoids [27].…”

Section: Introductionmentioning

confidence: 99%

Studies on the interaction between promethazine and human serum albumin in the presence of flavonoids by spectroscopic and molecular modeling techniques

Wang

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Advances in the biotechnological glycosylation of valuable flavonoids

Cited by 275 publications

References 158 publications

Integrated genomics-based mapping reveals the genetics underlying maize flavonoid biosynthesis

Integrated genomics-based mapping reveals the genetics underlying maize flavonoid biosynthesis

Chemical composition and biological activities of n-butanol extract of <i>Lepidium sativum L</i> (Brassicaceae) seed

Studies on the interaction between promethazine and human serum albumin in the presence of flavonoids by spectroscopic and molecular modeling techniques

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