Advances in the Application and Impact of MicroRNAs as Therapies for Skin Disease

Lawrence, Paul; Ceccoli, Joseph

doi:10.1007/s40259-017-0243-4

Cited by 26 publications

(10 citation statements)

References 146 publications

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“…Among these, microRNA arrays are broadly used in research, including evaluating topical ingredients by utilizing real-time RT-PCR [ 17 , 19 , 20 ]. Finally, microRNAs in human skin aging have been reviewed recently along with the advances and applications of microRNAs as therapies for skin diseases like psoriasis [ 19 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it is interesting to find in this study that all three microRNAs identified were upregulated by BlendIP. Many studies that have examined different microRNAs from the skin showed that microRNAs are associated with skin cancers or skin diseases [ 18 , 19 , 20 , 38 , 39 ]. Finally, it is also important to understand how microRNAs keep the skin healthy, to prevent skin aging.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging

Namkoong

Kern

Knaggs

2018

IJMS

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Since the skin is the major protective barrier of the body, it is affected by intrinsic and extrinsic factors. Environmental influences such as ultraviolet (UV) irradiation, pollution or dry/cold air are involved in the generation of radical oxygen species (ROS) and impact skin aging and dermal health. Assessment of human skin gene expression and other biomarkers including epigenetic factors are used to evaluate the biological/molecular activities of key compounds in cosmetic formulas. The objective of this study was to quantify human gene expression when epidermal full-thickness skin equivalents were exposed to: (a) a mixture of betaine, pentylene glycol, Saccharomyces cerevisiae and Rhodiola rosea root extract (BlendE) for antioxidant, skin barrier function and oxidative stress (with hydrogen peroxide challenge); and (b) a mixture of Narcissus tazetta bulb extract and Schisandra chinensis fruit extract (BlendIP) for various biomarkers and microRNA analysis. For BlendE, several antioxidants, protective oxidative stress biomarkers and many skin barrier function parameters were significantly increased. When BlendE was evaluated, the negative impact of the hydrogen peroxide was significantly reduced for the matrix metalloproteinases (MMP 3 and MMP 12), the skin aging and oxidative stress biomarkers, namely FBN2, ANXA1 and HGF. When BlendIP was tested for cell proliferation and dermal structural components to enhance the integrity of the skin around the eyes: 8 growth factors, 7 signaling, 7 structural/barrier function and 7 oxidative stress biomarkers were significantly increased. Finally, when BlendIP was tested via real-time RT-PCR for microRNA expression: miR-146a, miR-22, miR155, miR16 and miR21 were all significantly increased over control levels. Therefore, human skin gene expression studies are important tools to assess active ingredient compounds such as plant extract blends to advance dermal hypotheses toward validating cosmetic formulations with botanical molecules.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging

Namkoong

Kern

Knaggs

2018

IJMS

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“…An increasing number of studies have supported that miRNAs are involved in morphogenesis and homeostasis of the skin and its appendages [6]. The miRNAs act as essential regulators of differentiation, proliferation, and survival at the cellular level of skin cells including keratinocytes [7,8] suggesting the role of miRNA in epidermal barrier integrity.…”

Section: Introductionmentioning

confidence: 99%

The Role of MicroRNAs in Epidermal Barrier

Lee

2020

IJMS

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MicroRNAs (miRNAs), which mostly cause target gene silencing via transcriptional repression and degradation of target mRNAs, regulate a plethora of cellular activities, such as cell growth, differentiation, development, and apoptosis. In the case of skin keratinocytes, the role of miRNA in epidermal barrier integrity has been identified. Based on the impact of key genetic and environmental factors on the integrity and maintenance of skin barrier, the association of miRNAs within epidermal cell differentiation and proliferation, cell–cell adhesion, and skin lipids is reviewed. The critical role of miRNAs in the epidermal barrier extends the use of miRNAs for control of relevant skin diseases such as atopic dermatitis, ichthyoses, and psoriasis via miRNA-based technologies. Most of the relevant miRNAs have been associated with keratinocyte differentiation and proliferation. Few studies have investigated the association of miRNAs with structural proteins of corneocytes and cornified envelopes, cell–cell adhesion, and skin lipids. Further studies investigating the association between regulatory and structural components of epidermal barrier and miRNAs are needed to elucidate the role of miRNAs in epidermal barrier integrity and their clinical implications.

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“…It is also known about cells with accelerated division behavior (e.g., tumor cells) that transiently released miRNAs are as well eliminated faster, making them less suitable as therapeutic target structures [11]. Various experimental approaches have been described regarding the use of miRNA-based therapies for the treatment of skin tumors, but there have been only a few clinical investigations so far [12, 13].…”

Section: Introductionmentioning

confidence: 99%

Importance of microRNAs in Skin Oncogenesis and Their Suitability as Agents and Targets for Topical Therapy

Gerloff

Sunderkötter

Wohlrab

2020

Skin Pharmacol Physiol

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Skin cancer is the most common cancer worldwide, with rapidly increasing incidence and consistent mortality. Skin cancer encompasses melanoma and non-melanoma skin cancer, which in turn is mainly divided into cutaneous squamous cell carcinoma and basal cell carcinoma. Small noncoding microRNAs (miRNAs) regulate protein expression after transcription and play a role in the development and progression of skin cancer. Deregulated expression of miRNAs in skin cancer is associated with cell proliferation, angiogenesis, metastasis, apoptosis, immune response, and drug resistance. Specific patterns of miRNAs in specific skin cancer types can be used as diagnostic markers. For therapeutic purposes, both miRNA and chemically modified variants thereof as well as miRNA antagonists (antagomiRs) or RNA inhibitors may be applied topically. Due to their specific physicochemical properties, physical or chemical diffusion promoters are used with varying degrees of success. There is no question by now that such preparations have a high potential for the treatment of epithelial skin tumors in particular.

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Advances in the Application and Impact of MicroRNAs as Therapies for Skin Disease

Cited by 26 publications

References 146 publications

Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging

Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging

The Role of MicroRNAs in Epidermal Barrier

Importance of microRNAs in Skin Oncogenesis and Their Suitability as Agents and Targets for Topical Therapy

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