Advances in surface‐enhanced Raman spectroscopy for cancer diagnosis and staging

Chakraborty, Avishek; Ghosh, Aritri; Barui, Ananya

doi:10.1002/jrs.5726

Cited by 42 publications

(23 citation statements)

References 195 publications

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“…However, the imaging capability (sensitivity and speed) of SERS is largely limited so far. In addition, compared with SRS, application of SERS was also limited by biocompatibility of metal nanoparticles, slow point measurements, sample preparation, and it could not provide quantitative information of insoluble species in tissues 39 , 40 . On the contrary, the formation of MSU depositions ensures high local concentration that allows SRS to generate sufficiently strong signals to image at high speed.…”

Section: Discussionmentioning

confidence: 99%

Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering

Zhang

Zhu

et al. 2021

Theranostics

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Gout is a common metabolic disease with growing burden, caused by monosodium urate (MSU) microcrystal deposition. In situ and chemical-specific histological identification of MSU is crucial in the diagnosis and management of gout, yet it remains inaccessible for current histological methods. Methods: Stimulated Raman scattering (SRS) microscopy was utilized to image MSU based on its fingerprint Raman spectra. We first tested SRS for the diagnosis capability of gout and the differentiation power from pseudogout with rat models of acute gout arthritis, calcium pyrophosphate deposition disease (CPDD) and comorbidity. Then, human synovial fluid and surgical specimens (n=120) were were imaged with SRS to obtain the histopathology of MSU and collagen fibers. Finally, quantitative SRS analysis was performed in gout tissue of different physiological phases (n=120) to correlate with traditional histopathology including H&E and immunohistochemistry staining. Results: We demonstrated that SRS is capable of early diagnosis of gout, rapid detection of MSU in synovial fluid and fresh unprocessed surgical tissues, and accurate differentiation of gout from pseudogout in various pathophysiological conditions. Furthermore, quantitative SRS analysis revealed the optical characteristics of MSU deposition at different pathophysiological stages, which were found to matched well with corresponding immunofluorescence histochemistry features. Conclusion: Our work demonstrated the potential of SRS microscopy for rapid intraoperative diagnosis of gout and may facilitate future fundamental researches of MSU-based diseases.

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Section: Discussionmentioning

confidence: 99%

Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering

Zhang

Zhu

et al. 2021

Theranostics

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“…For example, SERRS nanoparticles have been conjugated with folic acid, or cyclic Arg-Gly-Asp (cRGD) peptide to specifically target folate-receptorexpressing ovarian tumor and integrin-expressing brain tumor, respectively. [60][61][62] They have also been conjugated with tissue-factor targeting antibodies to detect pulmonary micrometastases to the lung. [63] As nanoparticles may not be readily excreted from the body, it is highly desirable to formulate SERRS contrast agents with negligible toxicity -a necessary prerequisite to facilitate their regulatory approval and clinical translation.…”

Section: Principles Of Raman Scattering Surface Enhanced Raman Scattering (Sers) and Surface Enhanced Resonance Raman Scattering (Serrs)mentioning

confidence: 99%

Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology

Kenry¹,

Nicolson²,

Clark³

et al. 2022

Nanotheranostics

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In the last two decades, the application of surface enhanced Raman scattering (SERS) nanoparticles for preclinical cancer imaging has attracted increasing attention. Raman imaging with SERS nanoparticles offers unparalleled sensitivity, providing a platform for molecular targeting, and granting multiplexed and multimodal imaging capabilities. Recent progress has been facilitated not only by the optimization of the SERS contrast agents themselves, but also by the developments in Raman imaging approaches and instrumentation. In this article, we review the principles of Raman scattering and SERS, present advances in Raman instrumentation specific to cancer imaging, and discuss the biological means of ensuring selective in vivo uptake of SERS contrast agents for targeted, multiplexed, and multimodal imaging applications. We offer our perspective on areas that must be addressed in order to facilitate the clinical translation of SERS contrast agents for in vivo imaging in oncology.

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“…The primary focus of the methodology is on spontaneous Raman spectroscopy and coherent Raman scattering (CRS) microscopy. Readers interested in surface-enhanced Raman scattering and other Raman-based methodologies are referred to excellent reviews elsewhere [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Unveiling Cancer Metabolism through Spontaneous and Coherent Raman Spectroscopy and Stable Isotope Probing

Tong

Zois

et al. 2021

Cancers

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Metabolic reprogramming is a common hallmark in cancer. The high complexity and heterogeneity in cancer render it challenging for scientists to study cancer metabolism. Despite the recent advances in single-cell metabolomics based on mass spectrometry, the analysis of metabolites is still a destructive process, thus limiting in vivo investigations. Being label-free and nonperturbative, Raman spectroscopy offers intrinsic information for elucidating active biochemical processes at subcellular level. This review summarizes recent applications of Raman-based techniques, including spontaneous Raman spectroscopy and imaging, coherent Raman imaging, and Raman-stable isotope probing, in contribution to the molecular understanding of the complex biological processes in the disease. In addition, this review discusses possible future directions of Raman-based technologies in cancer research.

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Advances in surface‐enhanced Raman spectroscopy for cancer diagnosis and staging

Cited by 42 publications

References 195 publications

Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering

Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering

Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology

Unveiling Cancer Metabolism through Spontaneous and Coherent Raman Spectroscopy and Stable Isotope Probing

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