Advances in Surface-Enhanced Raman Scattering-Based Aptasensors for Food Safety Detection

Yan, Mengmeng; Li, Huidong; Li, Min; Cao, Xiaolin; She, Yongxin; Chen, Zilei

doi:10.1021/acs.jafc.1c05274

Cited by 37 publications

(13 citation statements)

References 105 publications

(203 reference statements)

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“…Molecules can be combined with SERS tags to form an immunocomplex whose structure disintegrates and releases Raman probes, causing signal alterations 121 . Similarly, SERS-based aptasensors have significantly progressed in the area of food safety 122 . To monitor medicine distribution and support PTT and PDT, the NP-Raman combination (manifested through SERS) may be combined with various theranostic techniques ( Figure 5 A ) 123 .…”

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

Singh¹,

Yadav²,

Dhillon³

et al. 2023

Nanotheranostics

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Although medical advances have increased our grasp of the amazing morphological, genetic, and phenotypic diversity of diseases, there are still significant technological barriers to understanding their complex and dynamic character. Specifically, the complexities of the biological systems throw a diverse set of challenges in developing efficient theranostic tools and methodologies that can probe and treat pathologies. Among several emerging theranostic techniques such as photodynamic therapy, photothermal therapy, magnetic resonance imaging, and computed tomography, Raman spectroscopy (RS) is emerging as a promising tool that is a label-free, cost-effective, and non-destructive technique. It can also provide real-time diagnostic information and can employ multimodal probes for detection and therapy. These attributes make it a perfect candidate for the analytical counterpart of the existing theranostic probes. The use of biocompatible nanomaterials for the fabrication of Raman probes provides rich structural information about the biological molecules, cells, and tissues and highly sensitive information down to single-molecule levels when integrated with advanced RS tools. This review discusses the fundamentals of Raman spectroscopic tools such as surface-enhanced Raman spectroscopy and Resonance Raman spectroscopy, their variants, and the associated theranostic applications. Besides the advantages, the current limitations, and future challenges of using RS in disease diagnosis and therapy have also been discussed.

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Section: Raman Probes For Theranosticsmentioning

confidence: 99%

Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

Singh¹,

Yadav²,

Dhillon³

et al. 2023

Nanotheranostics

View full text Add to dashboard Cite

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“…The rapid detection sensors for food toxins developed with MOFs are mainly based on three fundamental principles: (i) quenching luminous groups of MOFs such as the fluorescence and ultraviolet caused by the conjugated pi groups of ligands and lanthanide ion clusters ( Nong et al, 2020 ) (ii) capturing guest molecules by activated groups of MOFs or encapsulated constituents with further reactions (redox reaction and chromogenic reaction) and (iii) enhancing the spectral signals of target analytes located close to the plasmonic nanoparticles or nanostructured surfaces ( Yan et al, 2021 ; Chio et al, 2022 ). Therefore, the MOFs-based sensors employed in detecting food toxins can be divided into luminescent, electrochemical, colorimetric, and SERS sensors.…”

Section: Applications and Mechanisms Of Mofs-based Sensors In Toxins ...mentioning

confidence: 99%

Metal-Organic Frameworks-Based Sensors for the Detection of Toxins in Food: A Critical Mini-Review on the Applications and Mechanisms

Xuan

Wang

Manickam

et al. 2022

Front. Bioeng. Biotechnol.

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Using scientific technologies to detect toxins in food is significant to prevent food safety problems and protect people’s health. Recently, the rise of sensors has made rapid, efficient, and safe detection of food toxins possible. One of the key factors impacting the sensor’s performance is the nanomaterials employed. Metal-organic frameworks (MOFs), with high specific surface area, tunable composition, porous structure, and flexible properties, have aroused the interest of researchers. The applications of MOFs in detecting food toxins have seen remarkable success in the past few years. In this critical mini-review, the impact of various synthesis methods on MOFs’ properties is first presented. Then, the applications and mechanisms of MOFs-based sensors in detecting various toxins are summarized and analyzed. Finally, future perspectives, potential opportunities, and challenges in this field are discussed.

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“…1 Since the discovery of surface-enhanced Raman spectroscopy (SERS) over 40 years ago, 2 it has undergone a steady growth in interest from the research community. At present, it is widely applied in various fields, such as electrochemistry, 3 biology, 4 the prediction of disease, 5 food safety 6 and materials science. 7 Research has shown that the SERS effect is dependent on the use of SERS substrates.…”

Section: Introductionmentioning

confidence: 99%