Advances in Surface Chemistry of Nanodiamond and Nanodiamond–Polymer Composites

Neitzel, Ioannis; Mochalin, Vadym; Gogotsi, Yury

doi:10.1016/b978-1-4377-3465-2.00013-x

Cited by 17 publications

(9 citation statements)

References 111 publications

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“…25–27 As a result, ND has successfully demonstrated its ability to mechanically strengthen biopolymers 28,29 and function as a platform for the delivery of therapeutics with diverse chemistries. 26,30–33 While several studies have investigated the use of drug-loaded ND as an anti-inflammatory agent, the effects of ND on macrophage behaviour are poorly understood; some reports indicate no effects on inflammatory gene expression, 34–37 but at least one report shows reduced expression of inflammatory cytokines by murine macrophages.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages

et al. 2017

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Chronic inflammatory disorders such as rheumatoid arthritis are characterized by excessive pro-inflammatory or “M1” activation of macrophages, the primary cells of the innate immune system. Current treatments include delivery of glucocorticoids (e.g. dexamethasone – Dex), which reduce pro-inflammatory M1 behaviour in macrophages. However, these treatments have many off-target effects on cells other than macrophages, resulting in broad immunosuppression. To limit such side effects, drug-incorporated nano- and microparticles may be used to selectively target macrophages via phagocytosis, because of their roles as highly effective phagocytes in the body. In this study, surface-modified nanodiamond (ND) was explored as a platform for the delivery of dexamethasone to macrophages because of ND’s rich surface chemistry, which contributes to ND’s high potential as a versatile drug delivery platform. After finding that octadecylamine-functionalized nanodiamond (ND-ODA) enhanced adsorption of Dex compared to carboxylated ND, the effects of Dex, ND-ODA, and Dex-adsorbed ND-ODA on primary human macrophage gene expression were characterized. Surprisingly, even in the absence of Dex, ND-ODA had strong anti-inflammatory effects, as determined by multiplex gene expression via NanoString and by protein secretion analysis via ELISA. ND-ODA also inhibited expression of M2a markers yet increased the expression of M2c markers and phagocytic receptors. Interestingly, the adsorption of Dex to ND-ODA further increased some anti-inflammatory effects, but abrogated the effect on phagocytic receptors, compared to its individual components. Overall, the ability of ND-ODA to promote anti-inflammatory and pro-phagocytic behaviour in macrophages, even in the absence of loaded drugs, suggests its potential for use as an anti-inflammatory therapeutic to directly target macrophages through phagocytosis.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages

et al. 2017

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“…[ 30 ]. A nanocomposite is a multiphase material in which one of the phases has one, two, or three dimensions of less than 100 nm [ 58 ]. For instance, the material can consist of a combination of nanograins with different crystallographic orientations and/or different phases [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

Microstructure, Mechanical and Tribological Properties of Advanced Layered WN/MeN (Me = Zr, Cr, Mo, Nb) Nanocomposite Coatings

et al. 2022

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Due to the increased demands for drilling and cutting tools working at extreme machining conditions, protective coatings are extensively utilized to prolong the tool life and eliminate the need for lubricants. The present work reports on the effect of a second MeN (Me = Zr, Cr, Mo, Nb) layer in WN-based nanocomposite multilayers on microstructure, phase composition, and mechanical and tribological properties. The WN/MoN multilayers have not been studied yet, and cathodic-arc physical vapor deposition (CA-PVD) has been used to fabricate studied coating systems for the first time. Moreover, first-principles calculations were performed to gain more insight into the properties of deposited multilayers. Two types of coating microstructure with different kinds of lattices were observed: (i) face-centered cubic (fcc) on fcc-W2N (WN/CrN and WN/ZrN) and (ii) a combination of hexagonal and fcc on fcc-W2N (WN/MoN and WN/NbN). Among the four studied systems, the WN/NbN had superior properties: the lowest specific wear rate (1.7 × 10−6 mm3/Nm) and high hardness (36 GPa) and plasticity index H/E (0.93). Low surface roughness, high elastic strain to failure, Nb2O5 and WO3 tribofilms forming during sliding, ductile behavior of NbN, and nanocomposite structure contributed to high tribological performance. The results indicated the suitability of WN/NbN as a protective coating operating in challenging conditions.

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“…Improving ND nanofiller addition at higher concentration in matrices without aggregation needs to be resolved for future materials. 103 For conducting polymers, fine control over nanocomposite structure and features may be attained through interactions between the polymer matrix and the ND particles. In this regard, techniques to form a conjugated polymer-based nanoparticle can be of future interest in this field.…”

Section: Opportunities and Challengesmentioning

confidence: 99%

Review on conducting polymer/nanodiamond nanocomposites: Essences and functional performance

Kausar

2019

Journal of Plastic Film & Sheeting

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Conducting polymer technology doped with nanodiamond particles enhances processability, tractability, electrical, mechanical, electrochemical, optical, thermal, and other essential physical properties. This review outlines some major conducting polymer/nanodiamond nanocomposites advances obtained with major conjugated polymers such as: polyaniline, polypyrrole, polythiophene, and polythiophene derivatives. Moreover, this article concisely and inclusively discusses how important conducting polymer nanocomposites are for supercapacitor, actuator, solar cell, corrosion protection, and biomedical fields. Finally, challenges and perspectives are deliberated for viable future high performance materials.

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Advances in Surface Chemistry of Nanodiamond and Nanodiamond–Polymer Composites

Cited by 17 publications

References 111 publications

Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages

Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages

Microstructure, Mechanical and Tribological Properties of Advanced Layered WN/MeN (Me = Zr, Cr, Mo, Nb) Nanocomposite Coatings

Review on conducting polymer/nanodiamond nanocomposites: Essences and functional performance

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