Advances in Studies on Toxic Effects of Short-Chain Chlorinated Paraffins (SCCPs) and Characterization of Environmental Pollution in China

Zheng, Xin; Sun, Qianhang; Wang, Shuping; Li, Xiaoqian; Liu, Peiyuan; Yan, Zhenguang; Kong, Xianghui; Fan, Jun

doi:10.1007/s00244-020-00723-0

Cited by 19 publications

(5 citation statements)

References 74 publications

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“…Recent field evidence has revealed growing MCCP concentrations in the biotic and abiotic environments in China . There have also been debates on health consequences of SCCP due to its relatively low toxicity . However, some recent comprehensive investigations have reported non-eligible health risks of SCCP. , Because CPs have been widely used in plastic productions, food contaminated by CPs might occur in the storage and shipping.…”

Section: Methodssupporting

confidence: 88%

Assessing Safety of Market-Sold Fresh Fish: Tracking Fish Origins and Toxic Chemical Origins

Song

Huang

et al. 2022

Environ. Sci. Technol.

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Increasing global and domestic food trade and required logistics create uncertainties in food safety inspection due to uncertainties in food origins and extensive trade activities. Modern blockchain techniques have been developed to inform consumers of food origins but do not provide food safety information in many cases. A novel food safety tracking and modeling framework for quantifying toxic chemical levels in the food and the food origins was developed. By integrating chemicals’ multimedia environment exchange, food web, and source tracking systems, the framework was implemented to identify short-chain chlorinated paraffin (SCCP) contamination of fresh hairtail fish sold by a Walmart supermarket in Xi’an, northwestern China, and sourced in Eastern China Sea coastal waters. The framework was shown to successfully predict SCCP level with a mean of 17.8 ng g–1 in Walmart-sold hairtails, which was comparable to lab-analyzed 21.9 ng g–1 in Walmart-sold hairtails. The framework provides an alternative and cost-effective approach for safe food inspection compared to traditional food safety inspection techniques. These encouraging results suggest that the approach and rationale reported here could add additional information to the food origin tracking system to enhance transparency and consumers’ confidence in the traded food they consumed.

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Section: Methodssupporting

confidence: 88%

Assessing Safety of Market-Sold Fresh Fish: Tracking Fish Origins and Toxic Chemical Origins

Song

Huang

et al. 2022

Environ. Sci. Technol.

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“…5,12 In addition, CPs have characteristics of strong bioaccumulation and certain ecotoxicity, 13 such as endocrinedisrupting, developmental, and reproductive toxicity, 14,15 which may pose risks to marine biotas. 16,17 In marine biotas, SCCPs, MCCPs, and LCCPs have bioaccumulation and biomagnification potentials. 10,18−22 owing to their high logarithm octanol−water partition coefficient values (log K ow = 4.8−18.7) and resistance to metabolism.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the environmental persistence of CPs, they may be released into global marine environments from industrial sources via riverine input, long-range atmospheric transport, and ocean currents . Increasing evidence has also demonstrated that CPs exist in diverse marine environments, including the atmosphere, seawater, sediments, and biotas. − In marine environments, the concentration levels of CPs were similar to or even higher than legacy persistent organic pollutants (POPs). , In addition, CPs have characteristics of strong bioaccumulation and certain ecotoxicity, such as endocrine-disrupting, developmental, and reproductive toxicity, , which may pose risks to marine biotas. , …”

Section: Introductionmentioning

confidence: 99%

Bioaccumulation and Trophic Transfer of Short-, Medium-, and Long-Chain-Chlorinated Paraffins in Benthic Biotas of the Haima Cold Seep, South China Sea

Lyu,

Chen,

Fang

et al. 2024

ACS EST Water

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The bioaccumulation and trophic transfer of chlorinated paraffins (CPs) in deep-sea environments are vital, but no information is currently available. In the present study, CPs were analyzed in seawater, sediments, and benthic biotas from the Haima cold seeps, South China Sea. Total CP concentrations in biota ranged from 264.7 to 12874.4 ng/g of lipid weight, and their average concentrations, ranked from the highest to lowest, are as follows: sea cucumber ≈ slim tubeworm > crab > brittle star ≈ snail ≈ shrimp ≈ mussel > clam ≈ giant tubeworm. Benthic biotas displayed high accumulation abilities for SCCPs, MCCPs, and LCCPs, exhibiting at least medium-level pollution in the Haima cold seeps. Seawater was considered to be the primary source of CPs for biotas. Higher bioaccumulation potentials occurred in nonchemosymbiotic biotas than in chemosymbiotic biotas. Biomagnification for SCCPs and MCCPs and biodilution for LCCPs were observed between snails and mussels. No trophic transfer patterns were found in the whole benthic biota of the Haima cold seeps. This is the first report of CP bioaccumulation in the deep-sea environment. The results will provide insights into further studying the biological trophodynamics and ecological risks of CPs in deep-sea environments.

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“…Chlorinated paraffins (CPs) are a class of complex chlorinated derivatives of straight-chain n-alkanes with a wide range of industrial applications. CPs are bioaccumulative, biotoxic, and long-range migratory [1]. However, because CPs have the advantages of chemical stability, flame retardancy and low volatility, hundreds of products containing CPs have been developed and applied on a large scale so far, such as lubricants, plastic plasticizers, flame retardants, coating additives and so on [2].…”

Section: Introductionmentioning

confidence: 99%

Medium-chain chlorinated paraffins (MCCPs) induce renal cell aging and ferroptosis

Zhang,

Li,

Gao

et al. 2024

Aging

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Purpose: Medium-chained chlorinated paraffins (MCCPs) are a class of chlorinated derivatives of straight-chain n-alkanes with complex compositions, which are widely used in industry. The chlorinated paraffins (CPs) are divided into short chain chlorinated paraffins (SCCPs), medium chain chlorinated paraffins (MCCPs) and long chain chlorinated paraffins (LCCPs). SCCPs have been banned due to their severe bioaccumulation and biotoxicity. Therefore, MCCPs are used as a substitute for SCCPs. However, the toxicological data of MCCPs are still very limited. For this, we systematically investigated the toxicological impact of MCCPs on a renal cell model in the current study. Our work provides basic research data for analyzing the toxicological effects of MCCPs, suggesting that MCCPs should be restricted in their usage. Method: A series of biochemical experiments was performed, including Western blot, indirect immunofluorescence assay, and ELISA was performed to analyze the toxicological effects of MCCPs. Results: Two renal cell lines were used as a model for assessing the toxicological effects of MCCPs. Cell proliferation assays showed that MCCPs could inhibit the proliferation of kidney cells in a dose-dependent manner. Further studies showed that MCCPs induced ferroptosis in kidney cells by evaluating a series of ferroptosis marker molecules. Additionally, MCCPs induced inflammatory response and premature senescence in HEK293 and NRK-52E cells. Molecular mechanism experiments showed that ferroptosis induced by MCCPs emerged as a significant contributor to premature aging of kidney cells. Conclusion: The current study provides basic research data to analyze the toxicological effects of MCCPs and their toxicity mechanisms. It also provides a theoretical basis for the assessment of the potential ecological risk of MCCPs, as well as basic experimental data for the rational and standardized use of MCCPs.

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Advances in Studies on Toxic Effects of Short-Chain Chlorinated Paraffins (SCCPs) and Characterization of Environmental Pollution in China

Cited by 19 publications

References 74 publications

Assessing Safety of Market-Sold Fresh Fish: Tracking Fish Origins and Toxic Chemical Origins

Assessing Safety of Market-Sold Fresh Fish: Tracking Fish Origins and Toxic Chemical Origins

Bioaccumulation and Trophic Transfer of Short-, Medium-, and Long-Chain-Chlorinated Paraffins in Benthic Biotas of the Haima Cold Seep, South China Sea

Medium-chain chlorinated paraffins (MCCPs) induce renal cell aging and ferroptosis

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