Advances in Sonographic Detection of Ovarian Cancer: Depiction of Tumor Neovascularity With Microbubbles

Fleischer, Arthur C.; Lyshchik, Andrej; Andreotti, Rochelle F.; Hwang, Misun; Jones, Howard W.; Fishman, David A.

doi:10.2214/ajr.09.3446

Cited by 56 publications

(46 citation statements)

References 11 publications

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“…AUC corresponds to vascular volume, which is typically increased in tumors. Our findings showed significant differences in three of the four parameters with benign masses having longer 1/2 wash out time (140 seconds vs 46 seconds), greater enhancement (23 dB vs 12 dB) and larger AUC (2013 vs 524) than malignant masses [19]. In our preliminary data, microvascular ultrasound detected 20/20 malignancies including eight stage I cancers, while conventional ultrasound led to detection of only 12/20 cases.…”

Section: Im Agin G Studiesmentioning

confidence: 49%

“…Fleischer et al [19] have demonstrated that using pulse inversion harmonic imaging with microvascu lar contrast-enhanced ultrasonography may be even more accurate in aiding preoperative differentiation of benign and malignant ovarian tumors. Microbub ble contrast agents can help delineate and allow detection of the abnormal microvasculature unique to malignant tissue.…”

Section: Im Agin G Studiesmentioning

confidence: 99%

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Risk assessment for epithelial ovarian cancer: Proposing a new approach to a deadly problem

Chu

Fishman

2014

Scandinavian Journal of Clinical and Laboratory Investigation

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Presently the majority of women diagnosed with epithelial ovarian cancer (EOC) have advanced stage disease (III -IV) with a poor 5-year survival rate (12 -30 %). This signifi cantly contrasts when early stage disease is detected, which has a 5-year survival rate approximating 90 %. Therefore, detection of early stage disease is critical to making an impact on outcome. By using genetic algorithms, modifi cations of transvaginal ultrasonography and use of novel biomarkers, we propose a risk assessment profi le to identify at-risk women and enable ovarian cancer screening to become a reality. Such a novel algorithm starts by applying classic genetic pedigree assessment and uses a panel of multiple biomarkers that identify both phenotypic and genotypic expression of high-risk markers followed with conventional ultrasound and advanced ultrasound techniques such as microvascular contrast-enhancement as a secondary test. We presently employ a multidisciplinary program incorporating genetics, molecular biology, tumor immunology, gynecologic oncology and diagnostic imaging to identify asymptomatic high risk women.

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Section: Im Agin G Studiesmentioning

confidence: 49%

Section: Im Agin G Studiesmentioning

confidence: 99%

Risk assessment for epithelial ovarian cancer: Proposing a new approach to a deadly problem

Chu

Fishman

2014

Scandinavian Journal of Clinical and Laboratory Investigation

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“…Using microbubbles that are small enough to pass through capillaries, the kinetics of the blood flow can be analysed to detect abnormal flow found in areas of neovascularisation. [29] This has the potential for the detection and quantification of tumour angiogenesis at the molecular level. In a recent study, ultrasonographic microbubbles targeted with one of several antibodies (Anti-vascular endothelial growth factor receptor 2 and others) were injected into mice with implanted ovarian tumours.…”

Section: Discussionmentioning

confidence: 99%

Role of Combining Colour Doppler With Ultrasonography in T He Evaluation of Adnexal Masses

Suhasini¹,

Garuda²,

Sabitha³

2015

jemds

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PURPOSETo evaluate the appropriateness of combining colour Doppler with gray scale ultrasonography in suspicious adnexal masses. To evaluate the efficacy of this combination in differentiation of benign and malignant masses compared to 2D Gray Scale Ultrasonography alone. METHODSForty six patients with suspicious adnexal masses were evaluated. Morphological characterisation of the masses was done by Sassone Scoring. Colour Doppler parameters were noted and Caruso scoring done. The results were compared to surgical and histopathological findings. RESULTSUsing Sassone Scoring, overall reliability of differentiating adnexal masses had sensitivity of 85% and specificity of 76%. By using Caruso scoring a sensitivity of 85%, specificity of 90% was obtained. By combining sonomorphological score with Doppler indices, specificity increased to 80.9%, PPV increased from 63% to 70.3%. CONCLUSIONIn evaluation of adnexal masses combining Doppler indices with morphological scores gave higher specificity and positive predictive value.

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“…The halflife of the microbubbles is increased by functionalization with polyethylene glycol (PEGylation). CE US has been used in ovarian cancers to assess micro vascular changes, which helps differentiate between benign and malignant cancers [48][49][50]. The advantages of this imaging technique include the early detection of neovascularities at metastatic sites and monitoring of the response to antiangiogenic therapy in cancers [41,51,52].…”

Section: Imaging Of Ovarian Cancermentioning

confidence: 99%

Toward nanotechnology-based solutions for a particular disease: ovarian cancer as an example

Youkhanna

Syoufjy

Rhorer

et al. 2013

Nanotechnology Reviews

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Recent nanotechnology research has been enhancing or creating new applications that have the potential to advance the diagnosis or therapy of diseases. These contributions to the field of nanomedicine have so far been focused on creating the new technologies rather than focusing on particular diseases in order to improve their outcomes. For the latter to occur, we recommend the following: (1) creation of interdisciplinary research funding that awards collaborations between biological, medical, clinical, and pharmaceutical scientists with their colleagues in engineering, physics, and chemistry, (2) increasing the training of bio-and medical students in the field of nanotechnology, and (3) focusing on specific diseases for creating nano-based solutions. In this review, we focus on ovarian cancer as an example of a disease that could benefit from advances in nanotechnology to enhance its understanding, diagnosis, and therapy. We also stress the need to train biological, medical, clinical, and pharmaceutical students in the field of nanotechnology with presenting results on such training in USA pharmacy schools.

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Advances in Sonographic Detection of Ovarian Cancer: Depiction of Tumor Neovascularity With Microbubbles

Abstract: Microbubble-enhanced transvaginal sonography can enhance the evaluation of ovarian masses by early detection of tumor microvascularity.

Cited by 56 publications

References 11 publications

Risk assessment for epithelial ovarian cancer: Proposing a new approach to a deadly problem

Risk assessment for epithelial ovarian cancer: Proposing a new approach to a deadly problem

Role of Combining Colour Doppler With Ultrasonography in T He Evaluation of Adnexal Masses

Toward nanotechnology-based solutions for a particular disease: ovarian cancer as an example

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