Advances in serum‐free media for CHO cells: From traditional serum substitutes to microbial‐derived substances
Mingcan Zhang,
Xinyu Zhao,
Ying Li
et al.
Abstract:The Chinese hamster ovary (CHO) cell is an epithelial‐like cell that produces proteins with post‐translational modifications similar to human glycosylation. It is widely used in the production of recombinant therapeutic proteins and monoclonal antibodies. Culturing CHO cells typically requires the addition of a certain proportion of fetal bovine serum (FBS) to maintain cell proliferation and passaging. However, serum is characterized by its complex composition, batch‐to‐batch variability, high cost, and potent… Show more
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