Advances in research on the interaction between inflammation and cancer

Song, Xiaojing; Wang, Yani; Zhang, Aili; Liu, Bin

doi:10.1177/0300060519895347

Cited by 23 publications

(16 citation statements)

References 81 publications

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“…In fact, it is well documented how the reprogramming of energy metabolism is one of the key features of cancer and metabolic transformation is a central event in tumorigenesis [34]. Another hypothesis that might explain such changes might be due to increased lipid catabolism due to proin ammatory cytokines released by cancer [35]. It must be noticed, however, that we failed to demonstrate a statistically signi cant difference between metastatic and not-metastatic patients, thus lessening the potential impact of this factor as cytokines release should be obviously greater in patients with metastatic involvement compared to those without metastases.…”

Section: Discussionmentioning

confidence: 99%

Phase Angle Research Study in NeoplastIc Patients Treated with Standard Chemotherapy (PARSNIP)

Vignini

Copparoni

Pelati

et al. 2022

Preprint

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Purpose This study evaluated whether a series of analyses that are associated with physical state decay, such as phase angle (PhA), obtained by bio-electrical impedance analysis (BIA) performed before the first cycle (t0) and after 1-2 months (t1) of chemotherapy, might be associated with differences in a series of clinical factors. Methods In this monocentric, prospective, observational study we enrolled patients affected by solid tumors (breast or gastrointestinal cancers) treated with chemotherapy at our Institution between February and July 2019. We calculated whether a series of clinical factors (age, sex, type of chemotherapy regimen, metastatic vs not-metastatic disease involvement and different tumor type) might be associated with changes in PhA. BIA analysis was performed with DF50 Body Composition Analyzer. Statistical analysis was performed with statistical software R (4.1.0) and MedCalc® Statistical Software version 19.7.2. Results Thirty patients were enrolled, treated with chemotherapy in neoadjuvant, adjuvant or first line metastastic setting. In the whole cohort of patients, it was observed a reduction of PhA (p=0.02) between t0 and t1. Stratifying by clinical variables, female patients (p=0.02), younger patients (p=0.02), predominantly with not-metastatic involvement (p=0.03), affected by breast cancer (p<0.01) and who received taxane-based chemotherapy (p=0.01) were those a statistically significant difference in PhA between t0 and t1 was observed. Conclusion Our study suggest that PhA decrease is frequent as neoplastic disease worsens. BIA is an effective method for detecting PhA that seems to be a good indicator of patient’s malnutrition state. Selected subgroups of patients might be at higher risk of PhA decrease (females, breast cancer patients, younger patients, those treated with taxanes) and should be offered prompt nutritional assessment and support. Further studies in these subgroups of patients are recommended.

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Section: Discussionmentioning

confidence: 99%

Phase Angle Research Study in NeoplastIc Patients Treated with Standard Chemotherapy (PARSNIP)

Vignini

Copparoni

Pelati

et al. 2022

Preprint

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“…Further, STEAP4 expression is significantly increased in prostate cancer tissues, and it may be an indicator of prognosis for prostate cancer patients [55]. Cancer-associated inflammation is critical in tumor initiation and development [56,57], and lipopolysaccharides have been utilized to generate prostate inflammation.…”

Section: Discussionmentioning

confidence: 99%

STEAP Family Members and Gastric Cancer: Expression Profile and Prognostic Values

Naer

Lyu

et al. 2022

Preprint

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Background: The STEAP family is crucial in the control of metal homeostasis. A increasing amount of data suggests the link between epigenetic alterations in the STEAP family and a range of human malignancies. Nevertheless, the STEAP family's significance in gastric cancer is unclear, and there are few relevant research.Bioinformatics analysis was carried out using R software, Kaplan-Meier Plotter, cBioPortal, TIMER, LinkedOmics, STRING, Metascape, and GSCA Lite online tools.The expression of STEAP1/2/3 was dramatically upregulated in numerous tumor tissues, in particular, gastric cancer, but STEAP4 expression was significantly downregulated. Poor treatment results and aggressiveness of cancer are associated with high STEAP1/2/3 expression.Pathway analysis of the STEAP family and its co-expressed genes using Gene Ontology (GO) and Kyodo Encyclopedia of Genes and Genomes (KEGG) revealed that numerous gene terms were related with "iron ion homeostasis," "copper ion transport," "response to iron ion," and "iron ion transport." "response to iron ion," "oxidoreductase activity acting on metal ions," and "ion transport" The pathways are associated with "iron ion homeostasis," "copper ion transport," "react to iron ion," and "oxidoreductase activity involving metal ions."Notably, there was a positive correlation between STEAP 1/2/3 expression levels and oxidative stress genes,such as NOX3 and NOX4. PPI network analysis revealed that STEAP family proteins strongly interacted with TFRC. In addition, STEAP 1/2/3 expression was linked with B-cell, CD8+ T-cell infiltrating immune lymphocytes. Interestingly, Overexpression of STEAP 1/3 was also linked to decreased susceptibility of gastric cancer cells to a number of gastric cancer-targeting or chemotherapeutic drugs, including Docetaxel and Vorinostat. STEAP family members may be prognostic indicators and novel treatment targets for patients with gastric cancer.

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“…Antiinflammatory treatment has been shown to contribute to the prevention and treatment of cancer, confirming their correlation. Immune cells have been shown to be involved in various stages of tumor formation, which has enabled the development of new cancer treatment strategies [21,22].…”

Section: Inflammation and Tumor Inductionmentioning

confidence: 99%

Active Compounds in Fruits and Inflammation in the Body

Majdan

Bobrowska-Korczak

2022

Nutrients

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Inflammation plays an important role in the pathogenesis of many diseases, including cardiovascular diseases, atherosclerosis, diabetes, asthma, and cancer. An appropriate diet and the active compounds contained in it can affect various stages of the inflammatory process and significantly affect the course of inflammatory diseases. Recent reports indicate that polyphenolic acids, vitamins, minerals, and other components of fruits may exhibit activity stimulating an anti-inflammatory response, which may be of importance in maintaining health and reducing the risk of disease. The article presents the latest data on the chemical composition of fruits and the health benefits arising from their anti-inflammatory and antioxidant effects. The chemical composition of fruits determines their anti-inflammatory and antioxidant properties, but the mechanisms of action are not fully understood.

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Advances in research on the interaction between inflammation and cancer

Cited by 23 publications

References 81 publications

Phase Angle Research Study in NeoplastIc Patients Treated with Standard Chemotherapy (PARSNIP)

Phase Angle Research Study in NeoplastIc Patients Treated with Standard Chemotherapy (PARSNIP)

STEAP Family Members and Gastric Cancer: Expression Profile and Prognostic Values

Active Compounds in Fruits and Inflammation in the Body

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