Advances in Research on the Incidence, Risk and Treatment of Crohn’s Disease during Pregnancy

Abstract

Crohn's disease is an intestinal inflammatory disease of unknown cause, which is clinically divided into acute phase, subacute phase, and chronic phase. The disease symptoms can invade the entire digestive tract, and the most typical lesions are concentrated at the end of the ileum and its adjacent colon. The main manifestations of patients are diarrhea, abdominal pain, fistulas and perforating inflammation, most of which are in segmental and asymmetrical distribution. The symptoms are characterized by repeated attacks and alternating relief. There is no treatment plan to completely cure Crohn's disease. During pregnancy, the various systems of women's bodies have undergone tremendous changes due to the gestation of the fetus, so various complications are prone to occur, which is an important critical period for women of childbearing age. In addition, there are many contraindications to medication during pregnancy, so the treatment of ulcerative colitis during pregnancy has become a difficult problem. Therefore, urgent research for understanding the incidence, risk and treatment of Crohn's disease during pregnancy based on the existing evidence in practice diagnosis and treatment as well as the pregnancy safety information of relevant therapeutic drugs is required. Such research will help us accurately evaluate the corresponding diagnosis and treatment methods during pregnancy. Moreover, it can provide the best advice and management for patients with Crohn's disease who are pregnant and planning to become pregnant.