Advances in rectal drug delivery systems

Purohit, Trusha J.; Hanning, Sara M.; Wu, Zimei

doi:10.1080/10837450.2018.1484766

Cited by 93 publications

(69 citation statements)

References 81 publications

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“…Rectal administration is an advantageous alternative to the oral route for children and for patients with difficulty for swallowing or those with intense nausea and vomiting. The constraints associated with this route are the limited surface area for drug absorption and the small volume of the rectal fluids in which the drug must be dissolved [ 143 ]. CDs and their derivatives have also been employed to optimize drug rectal delivery.…”

Section: Resultsmentioning

confidence: 99%

Technological evolution of cyclodextrins in the pharmaceutical field

Rincón-López

Almanza-Arjona

Riascos

et al. 2021

Journal of Drug Delivery Science and Technology

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We herein disclose how global cyclodextrin-based pharmaceutical technologies have evolved since the early 80s through a 1998 patents dataset retrieved from Derwent Innovation Index. We used text-mining techniques based on the patents semantic content to extract the knowledge contained therein, to analyze technologies related to the principal attributes of CDs: solubility, stability, and taste-masking enhancement. The majority of CDs pharmaceutical technologies are directed toward parenteral aqueous solutions. The development of oral and ocular formulations is rapidly growing, while technologies for nasal and pulmonary routes are emerging and seem to be promising. Formulations for topical, transdermal, vaginal, and rectal routes do not account for a high number of patents, but they may be hiding a great potential, representing opportunity research areas. Certainly, the progress in materials sciences, supramolecular chemistry, and nanotechnology, will influence the trend of that, apparently neglected, research. The bottom line, CDs pharmaceutical technologies are still increasing, and this trend is expected to continue in the coming years. Patent monitoring allows the identification of relevant technologies and trends to prioritize research, development, and investment in both, academia and industry. We expect the scope of this approach to be applied in the pharmaceutical field beyond CDs technological applications.

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Section: Resultsmentioning

confidence: 99%

Technological evolution of cyclodextrins in the pharmaceutical field

Rincón-López

Almanza-Arjona

Riascos

et al. 2021

Journal of Drug Delivery Science and Technology

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“…Since rectal fluid has a weak buffering capacity, formulations that change rectal pH may affect drug absorption by altering drug ionisation and may cause irritation to rectal mucosa. The small volume of rectal fluid (around 1–3 ml) also poses difficulty for drug dissolution [ 109 ].…”

Section: Rectal Deliverymentioning

confidence: 99%

Transmucosal drug administration as an alternative route in palliative and end-of-life care during the COVID-19 pandemic

Lam

Cheung

Chow

et al. 2020

Advanced Drug Delivery Reviews

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The Coronavirus disease 2019 (COVID-19) pandemic has led to a surge in need for alternative routes of administration of drugs for end of life and palliative care, particularly in community settings. Transmucosal routes include intranasal, buccal, sublingual and rectal. They are non-invasive routes for systemic drug delivery with the possibility of self-administration, or administration by family caregivers. In addition, their ability to offer rapid onset of action with reduced first-pass metabolism make them suitable for use in palliative and end-of-life care to provide fast relief of symptoms. This is particularly important in COVID-19, as patients can deteriorate rapidly. Despite the advantages, these routes of administration face challenges including a relatively small surface area for effective drug absorption, small volume of fluid for drug dissolution and the presence of a mucus barrier, thereby limiting the number of drugs that are suitable to be delivered through the transmucosal route. In this review, the merits, challenges and limitations of each of these transmucosal routes are discussed. The goals are to provide insights into using transmucosal drug delivery to bring about the best possible symptom management for patients at the end of life, and to inspire scientists to develop new delivery systems to provide effective symptom management for this group of patients.

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“…Transmucosal drug delivery refers to the administration of therapeutic agents via mucosal membranes. The established routes of transmucosal administration include the oral cavity (buccal, gingival and sublingual) [56], esophagus [57], gastrointestinal tract (GIT) [58], nose [59], eyes [60], rectum [61], vagina [62], and urinary bladder [63]. Transmucosal drug delivery has several advantages including the ease of administration, non-invasive nature, and improved patient compliance.…”

Section: Transmucosal Drug Deliverymentioning

confidence: 99%

Silica Nanoparticles in Transmucosal Drug Delivery

Ways

Lau

et al. 2020

Pharmaceutics

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Transmucosal drug delivery includes the administration of drugs via various mucous membranes, such as gastrointestinal, nasal, ocular, and vaginal mucosa. The use of nanoparticles in transmucosal drug delivery has several advantages, including the protection of drugs against the harsh environment of the mucosal lumens and surfaces, increased drug residence time, and enhanced drug absorption. Due to their relatively simple synthetic methods for preparation, safety profile, and possibilities of surface functionalisation, silica nanoparticles are highly promising for transmucosal drug delivery. This review provides a description of silica nanoparticles and outlines the preparation methods for various core and surface-functionalised silica nanoparticles. The relationship between the functionalities of silica nanoparticles and their interactions with various mucous membranes are critically analysed. Applications of silica nanoparticles in transmucosal drug delivery are also discussed.

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Advances in rectal drug delivery systems

Cited by 93 publications

References 81 publications

Technological evolution of cyclodextrins in the pharmaceutical field

Technological evolution of cyclodextrins in the pharmaceutical field

Transmucosal drug administration as an alternative route in palliative and end-of-life care during the COVID-19 pandemic

Silica Nanoparticles in Transmucosal Drug Delivery

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