Advances in Radioembolization - Embolics and Isotopes

Burrill, Joshua; Häfeli, Urs O.; Liu, David M.

doi:10.4172/2155-9619.1000107

Cited by 22 publications

(31 citation statements)

References 36 publications

(38 reference statements)

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“…The remainder is permanently bound to the resin microspheres and does not leach under physiological conditions 43 . The specific gravity of resin microspheres is 1.6 g/dL (glass, 3.7 g/dL; blood, 1.05 g/dL), with a mean diameter of 32 μm 44, 45…”

Section: Microsphere Production and Physical Characteristicsmentioning

confidence: 99%

“…The density of the glass microspheres is 3.6 g/dL, which is approximately 3 times that of blood (1.05 g/dL). The specific activity of the glass microsphere is approximately 2500 Bq per sphere at the time of calibration 44 . There are 6 activity sizes available for delivery: 3, 5, 7, 10, 15, and 20 GBq.…”

Section: Microsphere Production and Physical Characteristicsmentioning

confidence: 99%

“…Although this does reduce radiation exposure to nuclear medicine staff and simplifies the steps involved in its administration, the inability to make changes to the treatment plan can be limiting. The ability to fractionate the activity of the delivered resin device allows for greater flexibility in timing of administration and changes to the treatment plan 44 . This does, however, result in more exposure to the nuclear medicine staff.…”

Section: Microsphere Production and Physical Characteristics: Advantamentioning

confidence: 99%

“…This should be repeated approximately 3 times to ensure thorough delivery of the activity 49 . At no time during the administration is it possible to inject contrast to evaluate for changes in flow within the hepatic artery 44, 69…”

Section: Activity Calculation and Deliverymentioning

confidence: 99%

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The development, commercialization, and clinical context of yttrium-90 radiolabeled resin and glass microspheres

Westcott

Coldwell

Liu

et al. 2016

Advances in Radiation Oncology

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Selective internal radiation therapy has emerged as a well-accepted therapeutic for primary and metastatic hepatic malignancies. This therapeutic modality requires the combined efforts of multiple medical disciplines to ensure the safe delivery of yttrium-90 (90Y)-labeled microspheres. The development of this therapy followed decades of clinical research involving tumor vascularity and microsphere development. Today, it is essential that treating physicians have a thorough understanding of hepatic tumor vascularity and 90Y microsphere characteristics before undertaking this complex intervention. This review explores the contributions of early investigators of this therapy, as well as the development, US Food and Drug Administration approval, manufacturing process, and attributes of the 2 commercially available 90Y radiolabeled microsphere device to clarify the key physical differences between the products.

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Section: Microsphere Production and Physical Characteristicsmentioning

confidence: 99%

Section: Microsphere Production and Physical Characteristicsmentioning

confidence: 99%

Section: Microsphere Production and Physical Characteristics: Advantamentioning

confidence: 99%

Section: Activity Calculation and Deliverymentioning

confidence: 99%

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The development, commercialization, and clinical context of yttrium-90 radiolabeled resin and glass microspheres

Westcott

Coldwell

Liu

et al. 2016

Advances in Radiation Oncology

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“…Many different kinds of microparticles are used for both diagnostic and therapeutic medical applications. The largest application for microspheres in medicine is drug delivery …”

Section: Introductionmentioning

confidence: 99%

Production and characterization of¹⁶⁶Ho polylactic acid microspheres

Yavari¹,

Yeganeh

Abolghasemi

2015

J. Label Compd. Radiopharm

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Microsphere and particle technology with selective transport of radiation represents a new generation of therapeutics. Poly-L-lactic acid (PLLA) microspheres loaded with holmium-166 acetylacetonate ((166)Ho-PLLA-MS) are novel microdevices. In this research, (165)HoAcAc-PLLA microparticles were prepared by the solvent evaporation technique. Microspheres were irradiated at Tehran Research Reactor. The diameter and surface morphologies were characterized by particle sizer and scanning electron microscopy before and after irradiation. The complex stability, radiochemical purity, and in vivo biodistribiotion were checked in the final solution up to 3 days. In this study, (166)Ho-PLLA spherical particles with a smooth surface and diameter of 20-40 µm were obtained, which were stable in vitro and in vivo studies. Neutron irradiation did not damage the particles. The ease with which the PLLA spheres could be made in the optimal size range for later irradiation and their ability to retain the (166)Ho provided good evidence for their potential use in radioembolization.

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